DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and SCIN

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001106177.1	Gene:	SCIN / 85477	HGNCID:	21695	Length:	715	Species:	Homo sapiens

Alignment Length:	722	Identity:	164/722 - (22%)
Similarity:	306/722 - (42%)	Gaps:	172/722 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  3736 LLHVKGRTHVQTRLVEPVHTSLNRGDCFILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDL 3800
            |||||||..|:...|.....|.|:|||||:..|::::::.||..|..|..::.::...|..|:..
Human   139 LLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGIRYNERK 203

  Fly  3801 GCTATQEVILTDGKYLKERQWRQFWQLLGKKED--DQSDIAECGHADEDDVFESSLIETNKIYEY 3863
            |  .::.:::.:|....|     ..::||:|.:  |..|       |:|.:.:.|..:..|:|..
Human   204 G--RSELIVVEEGSEPSE-----LIKVLGEKPELPDGGD-------DDDIIADISNRKMAKLYMV 254

  Fly  3864 QDEA------LIPLEKFWGCIPKVDMLDTRKVLVFDFGS--ELYVWNGKNAPSDAKRAAMRLAQE 3920
            .|.:      ::..|..:    .:.||.:.:..:.|.|:  :::||.||:|....::|||:.|:|
Human   255 SDASGSMRVTVVAEENPF----SMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMKTAEE 315

  Fly  3921 HFGAENSADYADCYLNPLNYVAIVGRRENTKYAKRCAQRPEWCVLGKITQNMETVLFKEKFSDWP 3985
                         :|..:||      .:||:             :..:.:..||.:||:.|.||.
Human   316 -------------FLQQMNY------SKNTQ-------------IQVLPEGGETPIFKQFFKDWR 348

  Fly  3986 EIERED-LEKDYLSNGVHMVRAL--NGTALHKGEPYQEPNLVLEQANLGRGNFYYDTDTMRHFDV 4047
            :.::.| ..|.|::..|..::.:  :.:.||     ..|.:..:...:..|
Human   349 DKDQSDGFGKVYVTEKVAQIKQIPFDASKLH-----SSPQMAAQHNMVDDG-------------- 394

  Fly  4048 ITKSTDKWQIHEFNFDAANNRDDYGHFYSAESYIVRWIYQISVTVRELSGKVSNRSTVGRDRCVY 4112
             :...:.|:: |.|.....:::.||.||..:.||:.:.|.                   |.:.:|
Human   395 -SGKVEIWRV-ENNGRIQVDQNSYGEFYGGDCYIILYTYP-------------------RGQIIY 438

  Fly  4113 FTWQGQDSSANEKGAAALLTVELDKEKG---AQMRVSQGDECTAFVRLFRQ----MWQHRGRKEQ 4170
             ||||.:::.:|...:|.|||:||:..|   .|:|||||.|....:.||:.    ::::...|:.
Human   439 -TWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKNGTSKKG 502

  Fly  4171 CLERHSEWRLYQLQGNVSEETIIKEVVCQSSHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTRNVA 4235
            ........||:|::.|::..|.|.||...::.|.| :.:.::...|.:..:|.|..::......|
Human   503 GQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNS-NDVFVLKLPQNSGYIWVGKGASQEEEKGA 566

  Fly  4236 VGVAQDL-IKTVPKDLFSAETANLTEVEEGSDDDQCKKALGLKDERNEYGSLLKSTKSFDYQIRI 4299
            ..||..| .||:             .::||.:.::...:||.|  ::...|.|..|::.|:..|:
Human   567 EYVASVLKCKTL-------------RIQEGEEPEEFWNSLGGK--KDYQTSPLLETQAEDHPPRL 616

  Fly  4300 FNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQLYNARQPTIFLLDDGDELWLWMGWWPLEDVK 4364
            :..|:..|.|...|:           |..|:|..|   .:..:.|||..:::::|:|
Human   617 YGCSNKTGRFVIEEI-----------PGEFTQDDL---AEDDVMLLDAWEQIFIWIG-------- 659

  Fly  4365 INTDERSSPTNENRAGVNRWISERRAALETAVDYWRA-KHGENENEPFHGIKGQVVWAGLEPLAF 4428
                   ...||         .|::.:|::|..|... ..|.::..|...||     .|.||..|
Human   660 -------KDANE---------VEKKESLKSAKMYLETDPSGRDKRTPIVIIK-----QGHEPPTF 703

  Fly  4429 KALFPDW 4435
            ...|..|
Human   704 TGWFLGW 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	26/88 (30%)
		gelsolin_like	3859..3965	CDD:200436	23/113 (20%)
		ADF_gelsolin	<4069..4158	CDD:301701	28/91 (31%)
		gelsolin_S5_like	4176..4279	CDD:200444	24/103 (23%)
		ADF_gelsolin	4328..4435	CDD:301701	23/107 (21%)
		VHP	4492..4526	CDD:280388
SCIN	NP_001106177.1	Actin-severing. /evidence=ECO:0000255	1..363		67/273 (25%)
		gelsolin_S1_like	10..121	CDD:200446
		Polyphosphoinositide binding. /evidence=ECO:0000250	112..119
		gelsolin_S2_like	136..225	CDD:200445	26/92 (28%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	138..146		6/6 (100%)
		gelsolin_S3_like	246..346	CDD:200448	28/135 (21%)
		Ca(2+)-dependent actin binding	364..715		97/447 (22%)
		gelsolin_S4_like	390..486	CDD:200449	32/131 (24%)
		gelsolin_S5_like	508..598	CDD:200444	24/105 (23%)
		gelsolin_S6_like	613..711	CDD:200447	30/141 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920