DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and VLN5

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001318818.1	Gene:	VLN5 / 835837	AraportID:	AT5G57320	Length:	962	Species:	Arabidopsis thaliana

Alignment Length:	975	Identity:	202/975 - (20%)
Similarity:	359/975 - (36%)	Gaps:	329/975 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  3738 HVKGRTHVQTRL-------------VEPVHTSLNRGDCFILVAGSQLFRYVGSFANVIEISRSKK 3789
            |||...| ||||             |..|.::||..|.|||...|::|::.||.:::.|.:::.:
plant   131 HVKPEEH-QTRLYICKGKHVVRVKEVPFVRSTLNHEDVFILDTESKIFQFSGSKSSIQERAKALE 194

  Fly  3790 ICAAIVEN-KDLGCTATQEVILTDGKYLKERQWRQFWQLLG------KKEDDQSDIAECGHADED 3847
            :...|.:. .|..|..   ..:.||:.:.:.:..:||.|.|      ||.          ..::|
plant   195 VVQYIKDTYHDGKCDI---AAVEDGRMMADAEAGEFWGLFGGFAPLPKKP----------AVNDD 246

  Fly  3848 DVFESSLIETNKIYEYQDEALIPLEKFWGCIPKVDMLDTRKVLVFDFGSELYVWNGKNAPSDAKR 3912
            :...|..|:...:.:.|.:| :..|    |:.| ::|||.|..:.|.|.||:||.|::...|.::
plant   247 ETAASDGIKLFSVEKGQTDA-VEAE----CLTK-ELLDTNKCYILDCGLELFVWKGRSTSIDQRK 305

  Fly  3913 AAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTKYAKRCAQRPEWCVLGKITQNMETVLF 3977
            :|...|:|.|                                |.::.|: ..|..:.:..|||:|
plant   306 SATEAAEEFF--------------------------------RSSEPPK-SNLVSVMEGYETVMF 337

  Fly  3978 KEKFSDWPE-----------------IEREDLEKDYLSNGVHMVRALNGTALHKGEPYQEPNLVL 4025
            :.||..||.                 ::|:.:      |...:|:..:.::..:.:||.:
plant   338 RSKFDSWPASSTIAEPQQGRGKVAALLQRQGV------NVQGLVKTSSSSSKDEPKPYID----- 391

  Fly  4026 EQANLGRGNFYYDTDTMRHFDVITKSTDKWQIH---EFNFDAANNRDDYGHFYSAESYIVRWIYQ 4087
                 |.||.                 ..|:|:   :...:||    :...|||.:.||:::.|.
plant   392 -----GTGNL-----------------QVWRINCEEKILLEAA----EQSKFYSGDCYILQYSYP 430

  Fly  4088 ISVTVRELSGKVSNRSTVGRDRCVYF--TWQGQDSSANEKGAAALLT---VELDKEKGAQMRVSQ 4147
                              |.||..:.  ||.|:.|...::.:|..|.   ||..|...||.|:::
plant   431 ------------------GEDREEHLVGTWFGKQSVEEDRASAISLANKMVESMKFVPAQARINE 477

  Fly  4148 GDECTAFVRLFRQMWQHRGRKEQCLERH-------------SEWRLYQLQGNVSEETIIKEVVCQ 4199
            |.|...|..:.:.....:|......:::             ....|:::||:..|.....::...
plant   478 GKEPIQFFVIMQSFITFKGGVSDAFKKYIAENDIPDTTYEAEGVALFRVQGSGPENMQAIQIEAA 542

  Fly  4200 SSHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKDLFSAETANLTEVEEG 4264
            |:.|.| |...::|| ...|..|.|:.::...:.:...:. ||||  |.:...|:       :||
plant   543 SAGLNS-SHCYILHG-DSTVFTWCGNLTSSEDQELMERML-DLIK--PNEPTKAQ-------KEG 595

  Fly  4265 SDDDQCKKALGLKDERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKALELSDPLRCQDLHSPYPF 4329
            |:.:|..:.||.|   :||.| .|..:..:....:|:.:.|....||.|:            :.|
plant   596 SESEQFWELLGGK---SEYPS-QKIKRDGESDPHLFSCTYTNESLKATEI------------FNF 644

  Fly  4330 SQSQLYNARQPTIFLLDDGDELWLWMGW---------------------WPLEDVKINT-----D 4368
            :|..|..   ..||:||...|:::|:|.                     :.||::...|     .
plant   645 TQDDLMT---EDIFILDCHTEVFVWVGQQVDPKKKPQALDIGENFLKHDFLLENLASETPIYIVT 706

  Fly  4369 ERSSPT--------NENRAGVNRWISERRAALET-----AVD--------YWRAKHGENENEP-- 4410
            |.:.|.        :.:::|::....:|:.|:.|     .:|        |.......::::|
plant   707 EGNEPPFFTRFFTWDSSKSGMHGDSFQRKLAILTNKGKPLLDKPKRRVPAYSSRSTVPDKSQPRS 771

  Fly  4411 ----FHGIKGQVVWAGLEPLAFKALFPDW-------------------------TERPDVREI-- 4444
                |...:.:|  .|..| ||.||..::                         :..||:.:|
plant   772 RSMTFSPDRARV--RGRSP-AFNALAANFEKLNIRNQSTPPPMVSPMVRKLYPKSHAPDLSKIAP 833

  Fly  4445 ----------------NEEDGRTDASISIATMLAQMTQT-------------------------- 4467
                            ..::..|..|.|.||..|:..::
plant   834 KSAIAARTALFEKPTPTSQEPPTSPSSSEATNQAEAPKSTSETNEEEAMSSINEDSKEEEAEEES 898

  Fly  4468 ---EYPLEVLKA---RPLPEGVEPTRLEVYLNAEDFQAALGCSRAEFEQLPIWKQTKLKKERGLF 4526
               .:|.|.||.   .|:.: |:.||.|.||.:.:|:.....::.||.:||.|||.|||....||
plant   899 SLPTFPYERLKTDSEDPVSD-VDLTRREAYLTSVEFKEKFEMTKNEFYKLPKWKQNKLKMSVNLF 962

Fly 4527 4526
plant 963 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	26/100 (26%)
		gelsolin_like	3859..3965	CDD:200436	23/105 (22%)
		ADF_gelsolin	<4069..4158	CDD:301701	24/93 (26%)
		gelsolin_S5_like	4176..4279	CDD:200444	26/102 (25%)
		ADF_gelsolin	4328..4435	CDD:301701	30/159 (19%)
		VHP	4492..4526	CDD:280388	12/33 (36%)
VLN5	NP_001318818.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020