DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Svil and CAPG

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001243068.1	Gene:	CAPG / 822	HGNCID:	1474	Length:	348	Species:	Homo sapiens

Alignment Length:	356	Identity:	79/356 - (22%)
Similarity:	135/356 - (37%)	Gaps:	107/356 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  3638 ERLVSKRHVQGPKGRRAARNPLKSLAAREDISSEYTEMRSGIAERELRRLK-----LESYGHNAN 3697
            ||.|..|.|||.:               .|:...|..          |.||     :||..|..:
Human    90 ERPVQHREVQGNE---------------SDLFMSYFP----------RGLKYQEGGVESAFHKTS 129

  Fly  3698 LAAEAIAGLASVEDFKSVALRSSSIPLQQMWLPHKPVMLLHVKGRTHVQTRLVEPVHTSLNRGDC 3762
            ..|.|             |::.                |..|||:.:::.........|.|.|||
Human   130 TGAPA-------------AIKK----------------LYQVKGKKNIRATERALNWDSFNTGDC 165

  Fly  3763 FILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVILTDGKYLKERQWRQFWQL 3827
            |||..|..:|.:.|..:|::|.::::.:..||.:::..|  ..|..|:|||:     :..:..|:
Human   166 FILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQG--KAQVEIVTDGE-----EPAEMIQV 223

  Fly  3828 LGKKEDDQSDIAECGHADEDDVFESSLIETNKIYEYQD-EALIPLEKFWGCIP-KVDMLDTRKVL 3890
            ||.|     ...:.|:.:||...:.:..:...:|:..| ...:.|.|.....| .:::|.:....
Human   224 LGPK-----PALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCF 283

  Fly  3891 VFDFG--SELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTKYA 3953
            |.|.|  .::|:|.|:.|....::||:::|:   |..:...||     |...|.|
Human   284 VLDNGLCGKIYIWKGRKANEKERQAALQVAE---GFISRMQYA-----PNTQVEI---------- 330

  Fly  3954 KRCAQRPEWCVLGKITQNMETVLFKEKFSDW 3984
                          :.|..|:.:||:.|.||
Human   331 --------------LPQGHESPIFKQFFKDW 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	25/91 (27%)
		gelsolin_like	3859..3965	CDD:200436	22/109 (20%)
		ADF_gelsolin	<4069..4158	CDD:301701
		gelsolin_S5_like	4176..4279	CDD:200444
		ADF_gelsolin	4328..4435	CDD:301701
		VHP	4492..4526	CDD:280388
CAPG	NP_001243068.1	gelsolin_S1_like	17..120	CDD:200446	12/54 (22%)
		Gelsolin-like 1	27..75
		gelsolin_S2_like	137..225	CDD:200445	26/110 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	137..146		4/24 (17%)
		Gelsolin-like 2	148..188		13/39 (33%)
		gelsolin_S3_like	251..346	CDD:200448	27/126 (21%)
		Gelsolin-like 3	261..307		11/45 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920