DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and VLN2

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001323674.1	Gene:	VLN2 / 818773	AraportID:	AT2G41740	Length:	976	Species:	Arabidopsis thaliana

Alignment Length:	976	Identity:	200/976 - (20%)
Similarity:	328/976 - (33%)	Gaps:	331/976 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  3740 KGRTHVQTRLVEPVHTSLNRGDCFILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDLGCTA 3804
            ||:..::.:.|....:|||..|.|||....:::::.|:.:|:.|.:::.::...:   ||.....
plant   143 KGKRAIRLKQVPFARSSLNHDDVFILDTEEKIYQFNGANSNIQERAKALEVVQYL---KDKYHEG 204

  Fly  3805 TQEV-ILTDGKYLKERQWRQFWQLLGKKEDDQSDIAECGH--ADEDDVFESSLIETNKIYEYQDE 3866
            |.:| |:.|||...|.....||.|.|       ..|..|.  |::||:...|  ...|:|...|.
plant   205 TCDVAIVDDGKLDTESDSGAFWVLFG-------GFAPIGRKVANDDDIVPES--TPPKLYCITDG 260

  Fly  3867 ALIPLEKFWGCIPKVDMLDTRKVLVFDFGSELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYA 3931
            .:.|::   |.:.| .||:..|..:.|.|:|:|:|.|:....|.::||.:.|:|...:||
plant   261 KMEPID---GDLSK-SMLENTKCYLLDCGAEIYIWVGRVTQVDERKAASQSAEEFLASEN----- 316

  Fly  3932 DCYLNPLNYVAIVGRRENTKYAKRCAQRPEWCVLGKITQNMETVLFKEKFSDWPEIEREDLEKDY 3996
                                       ||:...:.::.|..|:..||..|..||
plant   317 ---------------------------RPKATHVTRVIQGYESHSFKSNFDSWP----------- 343

  Fly  3997 LSNGVHMVRALNGTALHKGEPYQ-EPNLVLEQANLGRGNFYYDTDTMRHFDVITKSTDKWQIHEF 4060
                       :|:|....|..: :...:|:|..:|................:.:|..|.::...
plant   344 -----------SGSATPGNEEGRGKVAALLKQQGVGLKGIAKSAPVNEDIPPLLESGGKLEVWYV 397

  Fly  4061 NFDAAN--NRDDYGHFYSAESYIVRWIYQISVTVRELSGKVSNRSTVGRDRCVYFTWQGQDSSAN 4123
            |.....  .::|.|..||.:.|:|.:.|.        ||:       .:|......|.|:.|...
plant   398 NGKVKTPLPKEDIGKLYSGDCYLVLYTYH--------SGE-------RKDEYFLSCWFGKKSIPE 447

  Fly  4124 EKGAAALLTVELD---KEKGAQMRVSQGDECTAFVRLFRQM-----------WQHRGRKEQCLER 4174
            ::..|..|...:.   |.:..|.|:.:|.|...||.||:.|           ....|..|...|.
plant   448 DQDTAIRLANTMSNSLKGRPVQGRIYEGKEPPQFVALFQPMVVLKGGLSSGYKSSMGESESTDET 512

  Fly  4175 HS--EWRLYQLQGNVSEETIIKEVVCQSSHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTRNVAVG 4237
            ::  ...|.|:.|.........:|...::.|.|....||..|:  ::.:|||::|......:|..
plant   513 YTPESIALVQVSGTGVHNNKAVQVETVATSLNSYECFLLQSGT--SMFLWHGNQSTHEQLELATK 575

  Fly  4238 VAQDLIKTVPKDLFSAETANLTEVEEGSDDDQCKKALGLKDERNEYGSLLKSTKSFDYQIR---I 4299
            ||:          |......|...:||::......|||.|..       ..|.|:....||   :
plant   576 VAE----------FLKPGITLKHAKEGTESSTFWFALGGKQN-------FTSKKASSETIRDPHL 623

  Fly  4300 FNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQLYNARQPTIFLLDDGDELWLWMGWW--PLED 4362
            |:|:..:|.|:..|:            |.|:|..|..   ..|:.||...|:::|:|..  |.|.
plant   624 FSFAFNRGKFQVEEI------------YNFAQDDLLT---EDIYFLDTHAEVFVWVGQCVEPKEK 673

  Fly  4363 --------------------------VKIN----------------------------------- 4366
                                      .|||
plant   674 QTVFEIGQKYIDLAGSLEGLHPKVPIYKINEGNEPCFFTTYFSWDATKAIVQGNSFQKKASLLFG 738

  Fly  4367 ----TDERSSPTNE--------------------NRAGVN------------RWISERRAALETA 4395
                .:::|:..|:                    ||...:            |..:|..|||.:|
plant   739 THHVVEDKSNGGNQGLRQRAEALAALNSAFNSSSNRPAYSSQDRLNESHDGPRQRAEALAALSSA 803

  Fly  4396 ------------------------------------------------------------VDYWR 4400
                                                                        :....
plant   804 FNSSSSSTKSPPPPRPVGTSQASQRAAAVAALSQVLVAENKKSPDTSPTRRSTSSNPADDIPLTE 868

  Fly  4401 AKHGENENEPFHGIKGQVVWAGLEPLAFKALFP--DWTERPDVREINEEDGRTDASISIATMLAQ 4463
            ||..|..:|.          ||||....:.:.|  |.||   .::..||.|.::...|.||
plant   869 AKDEEEASEV----------AGLEAKEEEEVSPAADETE---AKQETEEQGDSEIQPSGAT---- 916

  Fly  4464 MTQTEYPLEVLKAR---PLPEGVEPTRLEVYLNAEDFQAALGCSRAEFEQLPIWKQTKLKKERGL 4525
                 :..|.|:|:   |: .|::..|.|.||:.|:||:..|..:..|..||.|||..|||:..|
plant   917 -----FTYEQLRAKSENPV-TGIDFKRREAYLSEEEFQSVFGIEKEAFNNLPRWKQDLLKKKFDL 975

  Fly  4526 F 4526
            |
plant   976 F 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	22/85 (26%)
		gelsolin_like	3859..3965	CDD:200436	24/105 (23%)
		ADF_gelsolin	<4069..4158	CDD:301701	22/91 (24%)
		gelsolin_S5_like	4176..4279	CDD:200444	24/104 (23%)
		ADF_gelsolin	4328..4435	CDD:301701	33/267 (12%)
		VHP	4492..4526	CDD:280388	14/33 (42%)
VLN2	NP_001323674.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020