DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and VLN1

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001189635.1	Gene:	VLN1 / 817539	AraportID:	AT2G29890	Length:	933	Species:	Arabidopsis thaliana

Alignment Length:	1034	Identity:	211/1034 - (20%)
Similarity:	367/1034 - (35%)	Gaps:	314/1034 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  3670 SEYTEMRSGIAERELRRL--KLES--------YGHNAN-----------LAAEAIAGLASV---- 3709
            |.:.:..||.|...||..  |:||        .|.:||           |..:|..|..:|
plant    37 SSFGKFHSGNAYLVLRTFLRKIESPQYDIHYWLGIDANEVDSILASDKALDLDAALGCCTVQYRE 101

  Fly  3710 ------EDFKSVALRSSSIPLQQMWLPHK-------PVMLLHVKGRTHVQTRLVEPVHTSLNRGD 3761
                  |.|.|. .:...||::..:.|..       .|.||..||...|:.:.|..:.:|||..|
plant   102 VQGQETEKFLSY-FKPCIIPVEGKYSPKTGIAGETYQVTLLRCKGDHVVRVKEVPFLRSSLNHDD 165

  Fly  3762 CFILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDLG-C-TATQEVILTDGKYLKERQWRQF 3824
            .|||...|::|.:.|..::..|.:::.::...|.:||..| | .||.|    |||:..:....:|
plant   166 VFILDTASKVFLFAGCNSSTQEKAKAMEVVEYIKDNKHDGRCEVATIE----DGKFSGDSDAGEF 226

  Fly  3825 WQLLGKKEDDQSDIAECGHADEDDVFESSLIETNKIYEYQDEALIP-LEKFW------------G 3876
            |...|            |:|....:..|:.         |::...| .|.||            .
plant   227 WSFFG------------GYAPIPKLSSSTT---------QEQTQTPCAELFWIDTKGNLHPTGTS 270

  Fly  3877 CIPKVDMLDTRKVLVFDFGSELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLNYV 3941
            .:.| |||:..|..:.|..||::||.|:|.....::.::..::|....|
plant   271 SLDK-DMLEKNKCYMLDCHSEVFVWMGRNTSLTERKTSISSSEEFLRKE---------------- 318

  Fly  3942 AIVGRRENTKYAKRCAQRPEWCVLGKITQNMETVLFKEKFSDWPEIEREDLEKDYLSNGVHMVRA 4006
               ||...|.             |..:|:.:|...|:..|:.||    :.:|....:.|...|
plant   319 ---GRSTTTS-------------LVLLTEGLENARFRSFFNKWP----QTVESSLYNEGREKV-- 361

  Fly  4007 LNGTALHKGEPYQEPNLVLEQANLGRGNFYYDTDTMRHFDVITKSTDKWQIHEFNFDAAN--NRD 4069
               .||.|.:.|....|..|:.:                .:.|...|..::...:.|..:  :..
plant   362 ---AALFKQKGYDVEELPDEEDD----------------PLYTNCRDNLKVWRVDGDDVSLLSIP 407

  Fly  4070 DYGHFYSAESYIVRWIYQISVTVRELSGKVSNRSTVGRDRCVYFTWQGQDSSANEKGAA---ALL 4131
            |....::.:.|:|::.|    |.:|            |...:.:.|.|.:|...::..|   |..
plant   408 DQTKLFTGDCYLVQYKY----TYKE------------RTEHLLYVWIGCESIQQDRADAITNASA 456

  Fly  4132 TVELDKEKGAQMRVSQGDECTAFVRLFRQMWQHRG-----------RKEQCLERHSEWR--LYQL 4183
            .|...|.:.....:.||:|.:.|..:|:.:...:|           .||:..|.::|.:  |:::
plant   457 IVGTTKGESVLCHIYQGNEPSRFFPMFQSLVVFKGGLSRRYKVLLAEKEKIGEEYNENKASLFRV 521

  Fly  4184 QGNVSEETIIKEVVCQSSHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTRNVAVGVAQDLIKTVPK 4248
            .|.........:|...::.|.|..|.:|.:|:  :...|.|..|:.....|           :.:
plant   522 VGTSPRNMQAIQVNLVATSLNSSYSYILQYGA--SAFTWIGKLSSDSDHEV-----------LDR 573

  Fly  4249 DLFSAETA-NLTEVEEGSDDDQCKKALGLKDERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKAL 4312
            .|:..:|: ....:.||::.|.....||.|.|..:...:.|..:    :..:|..|.:.|
plant   574 MLYFLDTSCQPIYIREGNETDTFWNLLGGKSEYPKEKEMRKQIE----EPHLFTCSCSSG----- 629

  Fly  4313 ELSDPLRCQDLHSPYPFSQSQLYNARQPTIFLLDDGDELWLWMG--------------------- 4356
              :|.|:.:::   |.|.|..|   ....:||||...|:::|:|
plant   630 --NDVLKVKEI---YNFVQDDL---TTEDVFLLDCQSEVYVWIGSNSNIKSKEEALTLGLKFLEM 686

  Fly  4357 ------------------------------WWP----------------LEDVKINT-------- 4367
                                          |.|                |:..|.:|
plant   687 DILEEGLTMRTPVYVVTEGHEPPFFTRFFEWVPEKANMHGNSFERKLASLKGKKTSTKRSSGSQY 751

  Fly  4368 ------------DERSSPTNENRAGVNRWISERRAALETAVDYWRAKHGE-------NENEPFHG 4413
                        ..||..:|.:..||:...||:..:|.:|.|...:.:..       :|:.....
plant   752 RSQSKDNASRDLQSRSVSSNGSERGVSPCSSEKLLSLSSAEDMTNSSNSTPVVKKLFSESLLVDP 816

  Fly  4414 IKGQVVWAGL--EPLAFKALFPDWTERPDVREINEE-DGRTDAS-----ISIATMLAQMTQTEYP 4470
            ..|:|.:..|  |.|.:      .|.:...|...:| ..::|.|     :.|.:.|:.:....|.
plant   817 NDGKVSYVNLFTERLGY------MTHKYQKRVARQESSSKSDISKQKPRVGINSDLSSLESLAYS 875

  Fly  4471 LEVLKA---RPLPEGVEPTRLEVYLNAEDFQAALGCSRAEFEQLPIWKQTKLKKERGLF 4526
            .|.|:.   :|:.: ::.||.|.||..::|:...|.:::||..||.|||.|||....||
plant   876 YEQLRVDSQKPVTD-IDATRREAYLTEKEFEERFGMAKSEFYALPKWKQNKLKISLHLF 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	29/93 (31%)
		gelsolin_like	3859..3965	CDD:200436	22/118 (19%)
		ADF_gelsolin	<4069..4158	CDD:301701	18/91 (20%)
		gelsolin_S5_like	4176..4279	CDD:200444	21/105 (20%)
		ADF_gelsolin	4328..4435	CDD:301701	31/202 (15%)
		VHP	4492..4526	CDD:280388	13/33 (39%)
VLN1	NP_001189635.1	gelsolin_S1_like	12..123	CDD:200446	21/86 (24%)
		gelsolin_S2_like	140..231	CDD:200445	30/94 (32%)
		gelsolin_S3_like	245..344	CDD:200448	27/131 (21%)
		gelsolin_S4_like	383..483	CDD:200449	21/115 (18%)
		gelsolin_S5_like	514..605	CDD:200444	20/103 (19%)
		gelsolin_S6_like	618..717	CDD:200447	16/111 (14%)
		VHP	898..933	CDD:128458	14/34 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11977
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020