DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Svil and Avil

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	XP_038935869.1	Gene:	Avil / 79253	RGDID:	620301	Length:	848	Species:	Rattus norvegicus

Alignment Length:	864	Identity:	205/864 - (23%)
Similarity:	340/864 - (39%)	Gaps:	224/864 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  3736 LLHVKGRTHVQTRLVEPVH-----------------------------TSLNRGDCFILVAGSQL 3771
            ||||||:.:::...|.|.|                             .|.|:||.|:|..|..:
  Rat   136 LLHVKGKRNIRATEVSPTHDCLGPVFLPWPLRPPQTALASPMQVEMSWDSFNQGDVFLLDLGMVI 200

  Fly  3772 FRYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVILTDGKYLKERQWRQFWQLLGKKEDDQS 3836
            .::.|..:|..|..:: .:.|..:.:::.|..|...||..|.:.............||::...:.
  Rat   201 IQWNGPESNSGERLKA-MLLAKDIRDRERGGRAEIGVIEGDKEAASPELMTVLQNTLGRRSIIKP 264

  Fly  3837 DIAECGHADEDDVFESSLIETNKIYEYQDE---------ALIPLEKFWGCIPKVDMLDTRKVLVF 3892
                   |..|:|.:.....|..:|...|.         |..||.:        ::|:.....:.
  Rat   265 -------AVPDEVTDQQQKSTIMLYHVSDTTGQLSVTEVATRPLVQ--------ELLNHDDCYIL 314

  Fly  3893 D-FGSELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTKYAKRC 3956
            | .|:::|||.||.|....|:|||..|                   |:::.:.|...:|.
  Rat   315 DQSGTKIYVWKGKGATKVEKQAAMSKA-------------------LDFIKMKGYPSSTN----- 355

  Fly  3957 AQRPEWCVLGKITQNMETVLFKEKFSDWP-EIEREDLEKDYLSNGVHMV--RALNGTALHKGEPY 4018
                    :..:....|:.:||:.|..|. :.:...|.|.:....:..:  ...:.|.||
  Rat   356 --------VETVNDGAESAMFKQLFQKWSVKDQTTGLGKTFSIGKIAKIFQDKFDVTLLH----- 407

  Fly  4019 QEPNLVLEQANLGRGNFYYDTDTMRHFDVITKSTDKWQIHEFNFDAANNRDDYGHFYSAESYIVR 4083
            .:|.:..::..:..||...:...:.:.:::..   ::|.|             |.||..:.|:|.
  Rat   408 TKPEVAAQERMVDDGNGKVEVWRIENLELVPV---EYQWH-------------GFFYGGDCYLVL 456

  Fly  4084 WIYQISVTVRELSGKVSNRSTVGRDRCVYFTWQGQDSSANEKGAAALLTVELDKEKG---AQMRV 4145
            :.|.::                |:...:.:.|||:.:|.:|..|:|...||:|::.|   .|:||
  Rat   457 YTYDVN----------------GKPCYILYIWQGRHASQDELAASAYQAVEVDQQFGGAPVQVRV 505

  Fly  4146 SQGDECTAFVRLFR---QMWQHRGRKEQCLERHSEWRLYQLQGNVSEETIIKEVVCQSSHLRSRS 4207
            |.|.|...|:.:|:   .:::....::..:|.....||:|:.||....|...||...:|.|.|..
  Rat   506 SMGKEPRHFMAIFKGKLVIYEGGTSRKGNVEPDPPVRLFQIHGNDKSNTKAVEVSASASSLNSND 570

  Fly  4208 SMLLIHGSQGNVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKDLFSAETANLTEVEEGSDDDQCKK 4272
            ..||  .:|....:|:|..|:...|.:|..:|:.|...      .|:|     |.||.:..:...
  Rat   571 VFLL--WTQAEHYLWYGKGSSGDERAMAKELAELLCDG------DADT-----VAEGQEPPEFWD 622

  Fly  4273 ALGLK-----DERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQS 4332
            .||.|     |:|.:..:|       |.|:|:|..|:..|.|...|::|            |:|.
  Rat   623 LLGGKAPYANDKRLQQETL-------DIQVRLFECSNKTGRFLVTEVTD------------FTQD 668

  Fly  4333 QLYNARQP-TIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGVNRWISERRAALETAV 4396
            .|    .| .:.|||..|:::||:|                      |..|  .:|:..||.||.
  Rat   669 DL----SPGDVMLLDTWDQVFLWIG----------------------AEAN--ATEKEGALSTAQ 705

  Fly  4397 DYWRAKH--GENENEPFHGIKGQVVWAGLEPLAFKALF----PD-WTERPDVREINEEDGRTDAS 4454
            :| ...|  |.:.:.|...||     .|.||..|...|    |. |:|.....::..|.|...|.
  Rat   706 EY-LVTHPSGRDPDTPILIIK-----QGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAI 764

  Fly  4455 ISIATMLAQMTQT---------EYPLEVL---KARPLPEGVEPTRLEVYLNAEDFQAALGCSRAE 4507
            :.|.|.:...|.:         .||:|||   :.:.|||.|:||:.|.||:..||.:..|.:|.:
  Rat   765 VRITTDMKNATLSLNSSESGPKYYPVEVLLKSQDQELPEDVDPTKKENYLSERDFVSVFGITRGQ 829

  Fly  4508 FEQLPIWKQTKLKKERGLF 4526
            |..||.|||.:||||.|||
  Rat   830 FVSLPGWKQLQLKKEAGLF 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	25/117 (21%)
		gelsolin_like	3859..3965	CDD:200436	22/115 (19%)
		ADF_gelsolin	<4069..4158	CDD:301701	25/91 (27%)
		gelsolin_S5_like	4176..4279	CDD:200444	29/107 (27%)
		ADF_gelsolin	4328..4435	CDD:301701	30/114 (26%)
		VHP	4492..4526	CDD:280388	16/33 (48%)
Avil	XP_038935869.1	gelsolin_S1_like	7..118	CDD:200446
		gelsolin_S2_like	133..252	CDD:200445	25/116 (22%)
		gelsolin_S3_like	276..374	CDD:200448	27/137 (20%)
		gelsolin_S4_like	418..518	CDD:200449	29/131 (22%)
		gelsolin_S5_like	539..629	CDD:200444	29/102 (28%)
		gelsolin_S6_like	646..741	CDD:200447	36/140 (26%)
		VHP	813..847	CDD:396679	16/33 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920