DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and qua

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001246066.1	Gene:	qua / 35058	FlyBaseID:	FBgn0003187	Length:	892	Species:	Drosophila melanogaster

Alignment Length:	940	Identity:	195/940 - (20%)
Similarity:	328/940 - (34%)	Gaps:	264/940 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  3688 KLESYGHNANLAAEAIAGLAS---VEDFKS-----VALRSSSIPLQQMWLPHKPVMLLHVKGRTH 3744
            :|:||..|.:........|.|   :..||.     .::||.::    :..|.:| .|..:..|..
  Fly   116 ELDSYLGNISSIYRETQNLESARFLSYFKKGYEFRFSVRSGAL----ISAPQRP-RLFQLYARKW 175

  Fly  3745 VQTRLVEPVHTS-LNRGDCFILVAGSQLFRYVGSFANVIEISRS-----KKICA----AIV---- 3795
            :::..|..:..| .|.....:|...:..:.::|..::.|| .||     :|.|:    .||
  Fly   176 LRSIEVATIDWSHFNSDYVMVLQTDNLTYVWIGRSSSGIE-RRSALDWVQKHCSGSPITIVDDGY 239

  Fly  3796 ------ENKDLGCTATQEVILTDGKYLKERQWRQFWQLLGKKEDDQSD---IAECG-----HADE 3846
                  |:|:|..|...         ||:|...|..||:.:..|..|:   |.:|.     |.|:
  Fly   240 EQAMSQEHKELWNTMLP---------LKKRMVCQASQLVSEYADYNSNKFRIYKCNQRGRLHLDQ 295

  Fly  3847 DDVFESSLIETNKIYEYQDEALIPLEKFWGCIPKVDMLDTRKVLVFD-FGSELYVWNGKNAPSDA 3910
            .||                          |...|.|:.|...|.:.| :|..:::|.|..||...
  Fly   296 LDV--------------------------GMPAKDDLSDAHGVYLLDNYGQSIWLWVGGQAPQAD 334

  Fly  3911 KRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTKYAKRCAQRPEWCVLGKITQNMETV 3975
            ..:||.                      |..|.|.::   ||       |:..::.::.:..|.|
  Fly   335 ALSAMG----------------------NGRAFVKKK---KY-------PDNTLVVRVLEGHEPV 367

  Fly  3976 LFKEKFSDWPEIEREDLEKDYLSNGVHMVRALNGTALHKGEPYQEPNLVLEQ--ANLGRGN---F 4035
            .||..|::|..:.:|:      :.|...|....| .|......:.|.:..:.  .:.|||.   :
  Fly   368 EFKRLFANWLNVWQEN------TRGHKPVSTKFG-KLDAHSLCERPKMAADTQLVDDGRGERVIY 425

  Fly  4036 YYDTDTMRHFDVITKSTDKWQIHEFNFDAANNRDDYGHFYSAESYIVRWIYQISVTVRELSGKVS 4100
            ....|.::... |:|:.                    .|.:..|::|::..|.:..|      .:
  Fly   426 RVFGDQVQEVP-ISKTV--------------------VFTTNASFVVKYSVQCATVV------PA 463

  Fly  4101 NRSTVGRDRCVYFTWQGQDSSANEKGAA---ALLTVELDKEKGAQMRVSQGDECTAFVRLFR-QM 4161
            :.::||....:| .|.|.::|......|   |..:.:..||.|..:::.:.||...|:::|. ::
  Fly   464 DLASVGIKTIIY-QWNGSEASVESISRADKFAKASFDGLKEPGMFVQLYEFDEPPHFLQIFEGKL 527

  Fly  4162 WQHRGRKEQCLERHSEWRLYQLQGNVSEETIIKEV---------VCQSSHLRSRSSMLLIHGSQG 4217
            ...||::.:        ..|....|...:|.:.:|         ..:.:||.|.||.........
  Fly   528 IIRRGQRTE--------MPYNGNSNALLDTFLLKVYGDASYNAKAVEETHLSSISSKDCYVIKTN 584

  Fly  4218 NVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKDLFSAETANLTEVEEGSDDDQC-----KKALGLK 4277
            :|.||.|..|        .|.|:::.|.|  .....|.:.:.|.:|..:..|.     .:.|.:.
  Fly   585 HVWVWCGQSS--------TGDAREMAKAV--GALMGENSLVLEGKESKEFWQSVAMYFNQTLVIN 639

  Fly  4278 DERNEYGSLLKSTKSFDYQIRIFNFSSTQG-VFKALELSDPLRCQDLHSPYP--------FSQSQ 4333
            ...|...|   ||.|......:.|.||..| :...|..:..|.......|.|        :.||.
  Fly   640 GNGNSCSS---STSSSSGAGSMCNGSSNGGNISPTLSNNCYLNTSVPSKPRPPVQLFLVWWQQSS 701

  Fly  4334 L----------YNARQPTIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGVNRWISER 4388
            |          .:......::||.|...::|:|              |...|:.|
  Fly   702 LRYEEILGFDQQDLSSDCTYILDTGSLTYVWLG--------------SQAPNQER---------- 742

  Fly  4389 RAALETAVDYWRAKHGENENEPFHGIKGQVVWAGL----EPLAFKALFPDWTERPDVREINEEDG 4449
                     |........:|.|| |.:.....|.:    ||..||..|..|.........:.|..
  Fly   743 ---------YTAIAQSYVQNAPF-GRRSATALAVVRQFQEPNVFKGFFESWQNDYGKNFHSYEKM 797

  Fly  4450 RTD-----------ASISIATMLAQMTQ-----TEYPLEVL--KARPLPEGVEPTRLEVYLNAED 4496
            |.|           ||...|.:|....:     .:|||.||  :...||..:.|.:.||:|..:|
  Fly   798 RKDLGNKVTSNCCFASEGSALILNNRQKDFDGHKKYPLTVLIQEMDMLPPDINPLKREVHLTHDD 862

  Fly  4497 FQAALGCSRAEFEQLPIWKQTKLKKERGLF 4526
            |.:....|..||::||.||:.:|||:..||
  Fly   863 FVSVFNMSFYEFDELPKWKKMELKKQFKLF 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	24/111 (22%)
		gelsolin_like	3859..3965	CDD:200436	19/106 (18%)
		ADF_gelsolin	<4069..4158	CDD:301701	19/91 (21%)
		gelsolin_S5_like	4176..4279	CDD:200444	23/116 (20%)
		ADF_gelsolin	4328..4435	CDD:301701	23/128 (18%)
		VHP	4492..4526	CDD:280388	13/33 (39%)
qua	NP_001246066.1	ADF_gelsolin	26..147	CDD:301701	8/30 (27%)
		gelsolin_like	164..254	CDD:200436	19/91 (21%)
		gelsolin_S3_like	276..375	CDD:200448	31/156 (20%)
		GEL	424..526	CDD:214590	23/129 (18%)
		ADF_gelsolin	551..625	CDD:301701	18/83 (22%)
		gelsolin_like	689..780	CDD:200436	21/124 (17%)
		VHP	857..892	CDD:128458	13/34 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11977
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020