DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and Vil1

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001101694.1	Gene:	Vil1 / 316521	RGDID:	1307048	Length:	827	Species:	Rattus norvegicus

Alignment Length:	849	Identity:	215/849 - (25%)
Similarity:	326/849 - (38%)	Gaps:	218/849 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  3736 LLHVKGRTHVQTRLVEPVHTSLNRGDCFILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDL 3800
            ||||||:.:|....||....|.||||.|:|..|..:.::.|..:|.:|..|
  Rat   139 LLHVKGKRNVLAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESNRMERLR-------------- 189

  Fly  3801 GCTATQEVILTDGKYLKERQWRQFWQLL-GKKEDDQSDI-----------AECGHADEDDVFESS 3853
            |.|..:|:  .|    :||..|.:..:: |:.|.|...:           .|...|..|.|.|.:
  Rat   190 GMTLAKEI--RD----QERGGRTYVGVVDGENEGDSPQLMAIMNHVLGPRKELKAAISDSVVEPA 248

  Fly  3854 LIETNKIYEYQDE---------ALIPLEKFWGCIPKVDMLDTRKVLVFDFGS-ELYVWNGKNAPS 3908
            .....|:|...|.         |..||.:        |:|......:.|.|. :::||.||||.
  Rat   249 AKAALKLYHVSDSEGKMVVREVATQPLTQ--------DLLSHEDCYILDQGGLKIFVWKGKNAN- 304

  Fly  3909 DAKRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTKYAKRCAQRPEWCVLGKITQNME 3973
                     |||..||.|.|         ||::             :..|.|....:.......|
  Rat   305 ---------AQERSGAMNQA---------LNFI-------------KAKQYPPSTQVEVQNDGAE 338

  Fly  3974 TVLFKEKFSDWPEIER-EDLEKDYLSNGVHMVRALNGTALHKGEPYQEPNLVLEQANLGRGNFYY 4037
            :.:|::.|..|....| ..|.|.:....|..|..:...||   ..:..|.:..:|..:..|
  Rat   339 SAIFQQLFQKWTVPNRTSGLGKTHTVGSVAKVEQVKFDAL---SMHVRPQVAAQQKMVDDG---- 396

  Fly  4038 DTDTMRHFDVITKSTDKWQIHEFNFDAANNRDDYGHFYSAESYIVRWIYQISVTVRELSGKVSNR 4102
                       :.....|:|.:.......:: ..||||..:.|::.:.|.|.
  Rat   397 -----------SGEVQVWRIEDLELVPVESK-WLGHFYGGDCYLLLYTYLIG------------- 436

  Fly  4103 STVGRDRCVYFTWQGQDSSANEKGAAALLTVELDK---EKGAQMRVSQGDECTAFVRLFR-QMWQ 4163
               .::..:.:.|||..:|.:|..|:|...|.||:   ::..|:||:.|.|....:.:|: :|..
  Rat   437 ---EKEHYLLYIWQGSQASQDEIAASAYQAVNLDQKYNDEPVQIRVTMGKEPPHLMSIFKGRMVV 498

  Fly  4164 HRG---RKEQCLERHSEWRLYQLQGNVSEETIIKEVVCQSSHLRSRSSMLLIHGSQGNVIVWHGS 4225
            ::|   ||.. :|.....||:|::|..::.|...||..:::.|.|....:|  .:.....:|.|.
  Rat   499 YQGGTSRKNN-VEPVPSTRLFQVRGTSADNTKAFEVTARATSLNSNDVFIL--KTPSCCYLWCGK 560

  Fly  4226 KSAPHTRNVAVGVAQDLIKTVPKDLFSAETANLTEVEEGSDDDQCKKALGLKDERNEYGSLLKST 4290
            ..:...|.:|..|| |.|....|.:          |.||.:......|||.|       :...:|
  Rat   561 GCSGDEREMAKMVA-DTISRTEKQV----------VVEGQEPANFWMALGGK-------APYANT 607

  Fly  4291 KSF--DYQI---RIFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQLYNARQPTIFLLDDGDE 4350
            |..  :.|:   |:|..|:..|.|.|.|:.|            |:|..|   .:..:||||..|:
  Rat   608 KRLQEENQVITPRLFECSNQTGRFLATEIFD------------FTQDDL---EEDDVFLLDVWDQ 657

  Fly  4351 LWLWMGWWPLEDVKINTDERSSPTNENRAGVNRWISERRAALETAVDYWRAKHGENENE-PFHGI 4414
            ::.|:|               ...||         .|::||..||.:|.:...|..:.| |.
  Rat   658 VFFWIG---------------KHANE---------EEKKAAATTAQEYLKTHPGNRDPETPI--- 695

  Fly  4415 KGQVVWAGLEPLAFKALF----P-DWTERPDVREINEEDGRTDASISIA--------------TM 4460
              .||..|.||..|...|    | .|:......::..|.|.:.....||              |.
  Rat   696 --IVVKQGHEPSTFTGWFLAWDPFKWSNTKSYDDLKAELGNSGDWSQIADEVMSPKVDVFTANTS 758

  Fly  4461 LAQMTQTEYPLEVLKARP---LPEGVEPTRLEVYLNAEDFQAALGCSRAEFEQLPIWKQTKLKKE 4522
            .:......||||.|..:|   |||||:|||.|.:|:.|||..|||.:.|.|..||.|||..||||
  Rat   759 FSSGPLPIYPLEQLVNKPVEELPEGVDPTRKEEHLSTEDFTKALGMTPAAFSALPRWKQQNLKKE 823

  Fly  4523 RGLF 4526
            :|||
  Rat   824 KGLF 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	28/88 (32%)
		gelsolin_like	3859..3965	CDD:200436	27/115 (23%)
		ADF_gelsolin	<4069..4158	CDD:301701	22/91 (24%)
		gelsolin_S5_like	4176..4279	CDD:200444	26/102 (25%)
		ADF_gelsolin	4328..4435	CDD:301701	29/112 (26%)
		VHP	4492..4526	CDD:280388	19/33 (58%)
Vil1	NP_001101694.1	gelsolin_S1_like	17..121	CDD:200446
		gelsolin_S2_like	136..225	CDD:200445	31/105 (30%)
		gelsolin_S3_like	250..348	CDD:200448	30/137 (22%)
		gelsolin_S4_like	392..492	CDD:200449	25/131 (19%)
		gelsolin_S5_like	513..603	CDD:200444	26/109 (24%)
		gelsolin_S6_like	619..715	CDD:200447	36/139 (26%)
		VHP	792..826	CDD:396679	18/33 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I11792
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920