DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Svil and svila

DIOPT Version :9

Sequence 1:NP_001286919.1 Gene:Svil / 38306 FlyBaseID:FBgn0266696 Length:4526 Species:Drosophila melanogaster
Sequence 2:XP_021335686.1 Gene:svila / 30112 ZFINID:ZDB-GENE-990706-5 Length:2264 Species:Danio rerio


Alignment Length:2671 Identity:693/2671 - (25%)
Similarity:1086/2671 - (40%) Gaps:714/2671 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  2147 CSSSTTSPQSSPAVRTTKASRLRAAALDKK-----------------------KEEEQRNRYSS- 2187
            |...|.  :::|.|..||  :.||.:..|:                       |..|.|.|:.| 
Zfish    17 CQGFTR--ETAPKVGNTK--QRRALSFQKEFSFEEKGEGANKEVDVSLLGNTPKVSELRKRFESI 77

  Fly  2188 PVSPKASSNGGVQAQRRLS--NSELSPKSPGASGFT----------------------------- 2221
            ..|.....|...:..|||.  ::::....||..|..                             
Zfish    78 STSQSWDMNRKERIARRLEGIDNDVLQSLPGCGGLVSNRLLEEDTPRYTRAADTCDPCTVSLQHY 142

  Fly  2222 --SEPVASATANRVPTRS-ASHPVDTPPT---------------------QRRQPLVAVSSGISM 2262
              |||  |:.:..||:|| |.||.....|                     :|||  :|...|||:
Zfish   143 GKSEP--SSQSTDVPSRSYAVHPESVFSTGSSHVAELDSKAERIARYKAERRRQ--LAERYGISL 203

  Fly  2263 KQSLSELHFTGGAVSPPKATAECTLRMRPRS---------STMSTENTENGRRDHLANLQLSPVQ 2318
            .|.: |..:|.....|.:.........|.:|         :..|:.:.:....|:    ..||..
Zfish   204 DQEM-ETDYTTRFSRPSRELDGSDRHHRSKSEGRDGVEQNAYTSSHHVDKSSSDY----HSSPEY 263

  Fly  2319 KQKRTPEVSPRRFGDRDKSAKRKSNL---NRSLTEEATKDGDEVA---------SSTRRRRRREL 2371
            .::||..:|.|         :|..||   .|:...:....|..||         |.:.|...||.
Zfish   264 SRERTDSISER---------ERMMNLENQRRAQERDRLHGGGGVAPDPSAYMDVSGSARVPGREP 319

  Fly  2372 GMARPLVPGDDDALRD--LLTPQKSSCSESTNSISEPHLQFIPAVRHPVVPVRTMTAVLPAPRPL 2434
            ||..  ||...::.|.  :|:|::.         :.|...||....|.::.....:         
Zfish   320 GMMG--VPSSPNSGRRGLMLSPKQG---------ASPGDLFIEQQAHSILQRHGQS--------- 364

  Fly  2435 HTPAARNVSQKFNERTKTDLAEIKKIAEQSEAQVQQPSVDDNQKMSAIMRRKSTDEGGSALGATN 2499
                    |.:::.:|.::...:..|...|..:|::....|    ....|.::|:|     .|.|
Zfish   365 --------SNQWSLQTDSEGDTVSPINWPSRIRVRERLARD----EPFHRGQTTEE-----PAYN 412

  Fly  2500 Q-------------NSPPAPNQIVSILKKKEHGLGECNS-------SASSNPSPVTFSSSVVDHP 2544
            |             :.|....|:....||:.|.:| |.|       |.|.|...:   ..||:. 
Zfish   413 QSYLRYYPHSQSLLDGPVKQQQLTRSEKKERHDMG-CQSYFSMGSESTSRNKQEI---QEVVEE- 472

  Fly  2545 LAGAGRCKRQGILKKRSSL--DESRYYSR------SHSPDERSILIKSARRNSLEEAGTGLSPAQ 2601
            :.|....:.:|:|:.|.::  .|.|...|      |.|.|.|.:....|...|.|  |....|..
Zfish   473 MEGKHVARTEGLLRSRKAVLPSEIRRKERNTDDSCSGSGDNREVSSAIAGHRSSE--GAANDPRG 535

  Fly  2602 AHGILKQSSYDSSKSDGCPSATESQPHSILKKKDSLSTPSDGGCHKHVSISQAV-TLAAAELAAH 2665
            .||                |....:.::                 :|||..||. :|.|....||
Zfish   536 WHG----------------SRARREVYT-----------------EHVSRLQAAESLQARAREAH 567

  Fly  2666 DGITFDDGEEHEIRPILKQESTSSEEAVRPPKPILKKKSFGEADEHEIRPILKSSRKSSREEFDL 2730
            .            ||.....:.....:.||.....|....|.. :..:.||.:..|::.::| .:
Zfish   568 R------------RPDASCCAPIQTSSARPMTNSSKPMDTGNT-QKTVLPIQEPIREAVQQE-KV 618

  Fly  2731 SGLENEVNDSLSSILKTDSPSKRRSLGSALHDLEESTTSPSMLK-------------RRTRSLER 2782
            ..:::..:|:            |.|:....|...:|..||...:             |..|..:|
Zfish   619 PNVDHLSHDA------------RVSVAHLRHTYLQSVASPRKAELAEELPAVTDVPWRSMRVRDR 671

  Fly  2783 QDVQPGMDLAAALDAIATSQATPSTPVDFVTTPTSISVAERIKRMEMLSTPTS------------ 2835
            ...:|       |..|..:::. .|...|.|.|.:.:..|:..|..:.|.|:|            
Zfish   672 SSRRP-------LRYICPTESR-KTSERFRTQPITSTEREQSDRSHLSSEPSSPEVDEEKLDERA 728

  Fly  2836 RAAGGANSSWESPLQASSAEHGAPTTPRVLKPSVLRRDLQR--ERYKTQPVTNEEMSFFKANSAP 2898
            :.:..|..|....|:.:|......|..|  .|:|.|| |:|  :|.:|||||.||:..  |.:||
Zfish   729 KLSVAAKRSLFRELEKTSDGSVLKTWSR--NPAVERR-LRRGQDRSRTQPVTTEEVVI--AATAP 788

  Fly  2899 FDISATSAFKPTKPLDIRLTHAPHAPLISPITGQPLSHVPAPLLLSSS-TNSGAGSSFRLARSST 2962
            ..:|.:...:.:                       ::.||:|.|:|:| |.....:|   ::.|:
Zfish   789 GHLSQSVTLQTS-----------------------ITRVPSPTLVSTSVTKHSLQAS---SQQSS 827

  Fly  2963 QPLQSPRVVHLAGQATGGSALARQNSVNDSINLSEQLTLSIGTDSEHIFEMSALEEDSAIQSLSD 3027
            ...:..|.|.||.:||                                      |.|.|      
Zfish   828 MVREQAREVRLAQEAT--------------------------------------ETDRA------ 848

  Fly  3028 ETAASASANSTSTTTATTMTPPSGLTRSNSVRARANMFQQL-QEQSRNQRATGTTNSR------Q 3085
             ..||...........:|:|          :..:..:|.:| |..|...||.|.|.:|      |
Zfish   849 -RHASPGEGGHEEPDLSTLT----------LAEKMALFNRLAQPSSHGSRARGDTRARRSNARYQ 902

  Fly  3086 SPPASSAEVSSSAADNSMHSDERSTPNATIDAEFGKPSTEPLKSILKTGMPVMGMGRGLMPVDLN 3150
            :.|.:..||....:.:.|..:|........|.|..:|:.                |....|    
Zfish   903 TQPITLGEVEQDGSGSEMFDEESEFSMCLSDLEHFQPAG----------------GARFAP---- 947

  Fly  3151 AELKNRLKRSTHATVSNLRKSATSADATRAASDEVDNPQRNLAQILRNVS------KENSTPKHD 3209
                        ::.|.:|.|..|   |..|.|        :...:.|||      :..|.|.|.
Zfish   948 ------------SSNSAMRSSTVS---TEHAGD--------IHLTMPNVSGPAYYEQTVSPPHHP 989

  Fly  3210 DAVSLVRNLSTLGQPRSLARDDAAGNCASASEGE----SSGGREIEA--IIKNSAVARRRRQQQQ 3268
            .....::...:|                  :|||    |:|.|::.:  .:|.:..|:..|....
Zfish   990 QPAHEIQTHQSL------------------AEGERLLLSTGKRKLPSPDSVKRTPHAQPARDWDS 1036

  Fly  3269 Q-----SQQQNQPDGNLVAKSKSHSGISAPIGLGPQLPPLPLGGGFVKLRHVAKEEDT--SSSSN 3326
            :     ||..:|.||       .|:            ..||:        |.|.....  |.|.:
Zfish  1037 KAVAVTSQDLSQTDG-------EHT------------TDLPV--------HTAAAVSALQSHSLH 1074

  Fly  3327 TSSAKESPDKKDLRQEQAEASGDSSHPTALPQFLQGVQRSSTEVMGPDQRSLVISKTGSIAERLA 3391
            ....:|...:.|.:.|..:...|                    ||...|.        ||.||||
Zfish  1075 EDHTREEEQESDFKTEDGDELSD--------------------VMSARQM--------SIKERLA 1111

  Fly  3392 ALHKSGEDDWKKRISKRDEV-----------------------DDVHRENFV----------NES 3423
            .|.||||:||:.||:|:.:|                       |.:..::|.          :.|
Zfish  1112 LLKKSGEEDWRNRINKKQDVVKVAVSERHAQLWEVEQSFKKKDDGMMIDDFAVSDQLWDPVFSSS 1176

  Fly  3424 LSLAHSLSDK--PLPPSPLIPTSLE----------GGKV--SDRLSKLKCNSENWKQRIEQ---- 3470
            |..|....|:  .||.:.|:|..::          |.:|  |.:|.:::.:.:..||.|..    
Zfish  1177 LLCASEPLDQIANLPKATLLPVQVDERHPWRRKKMGNEVVESQQLERVEMSIQERKQLITSQEEA 1241

  Fly  3471 ---------TDAKKFTVAGRLQKKAQSPVELQFERSANDAAKKCPMLEVRSANQPQLGLAKSPSM 3526
                     .|:.:||||||:.||                                 ||| :||:
Zfish  1242 WKAKGYGAANDSTQFTVAGRMVKK---------------------------------GLA-APSV 1272

  Fly  3527 MVTSSTSTNSTSKSALRSLSVNPEEEGPTSLSRSNSSSSESDGERKSPQN--AKQNKELANNKSA 3589
            :.....|..|:...........|.||    :....:...|||.:.:..:.  .:.|.::...:.|
Zfish  1273 LTNPVLSPLSSKNKNTSHTITKPHEE----IEVKQNMKLESDMKLEKLETFLGRLNSKVPGLQEA 1333

  Fly  3590 AAPTNVGARIQVPRLDDKETFENFF-SSKPKKEENVQLEIS-AFDDI------KPTERLVS-KRH 3645
            .......:..:|..||| |.|:.|: .::...:...::||| .||||      :.|..:|. ||.
Zfish  1334 TIAVTEKSVKEVMTLDD-EVFDKFYRHAEDMAKFTSRVEISDDFDDIFGVQLPRLTSEMVQHKRA 1397

  Fly  3646 VQGPKGRRAARNPLKSLAAREDISSEYTEMRSGIAERELRRLKLESYGHNANLAAEAIAGLASVE 3710
            |:..:..::::||||.||.||||..||||.|..|...|.:|:|.|....|:..:..|:|||||.|
Zfish  1398 VRPTRNVQSSKNPLKMLAVREDIRHEYTEQRLNIGLLESKRMKQEKMNKNSGFSEVALAGLASKE 1462

  Fly  3711 DFKSVALRSSSIPLQ---QMWLPHKPVMLLHVKGRTHVQTRLVEPVHTSLNRGDCFILVAGSQLF 3772
            :|.||:|||.:...|   ...:|:|.:||:.||||.|||||||||..:|||.||||:|:.....|
Zfish  1463 NFSSVSLRSVNASEQSSNNSAMPYKKLMLIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCF 1527

  Fly  3773 RYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVILTDGKYLKERQWRQFWQLLGKKEDDQSD 3837
            .::|.||||||.:::.::...:....||||.|:....:.:|........:.||::||.:...|| 
Zfish  1528 IWIGEFANVIEKAKAAELATFVQTKHDLGCRASYVQTIEEGANTHTHAAKDFWKILGGQTSYQS- 1591

  Fly  3838 IAECGHADEDDVFESSLIETNKIYEYQDEALIPLEKFWGCIPKVDMLDTRKVLVFDFGSELYVWN 3902
               .|..::|:.:||:::|||.||...::.|:|.:.:||.:|:..||:.::|||||||||:|||:
Zfish  1592 ---AGTPEQDEFYESAVVETNCIYRLMEDKLVPHDDYWGRVPRCSMLNPKEVLVFDFGSEVYVWH 1653

  Fly  3903 GKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLN---YVAIVGRRENTKYAKRCAQRPEWCV 3964
            ||......::.|.:||:..:  ..:.||.:|.:|||:   ..|::.|:..        .||:|.|
Zfish  1654 GKEVTLAQRKVAFQLAKHLW--NGTFDYTNCDINPLDPGECNALIPRKGQ--------GRPDWAV 1708

  Fly  3965 LGKITQNMETVLFKEKFSDWPEIEREDLEKDYLSNG-VHMVRALNGTALHKGE--PYQEP----- 4021
            .|::||:.||.||||||.||.:      .|:...|| :|    :....|..||  ||...     
Zfish  1709 FGRLTQHNETTLFKEKFLDWSD------SKNSKKNGDLH----VENKELRSGECRPYDASLMLSA 1763

  Fly  4022 -----NLVLEQANLGRGNFYYDTDTMRHFDVITKSTDKWQIHEFNFDAANNRDDYGHFYSAESYI 4081
                 ..||:..|:|||....:.:..|:|::.|.|.|.|.|.||::... .:...|.|:..::|:
Zfish  1764 LRAPVRTVLDGVNIGRGYGLVEGEEGRNFEISTLSVDVWHILEFDYSRL-PKQSIGQFHEGDTYV 1827

  Fly  4082 VRWIYQISVTVRELSGKVSNRSTV---GRDRCVYFTWQGQDSSANEKGAAALLTVELDKEKGAQM 4143
            |:|.|.||..|    ||..:...:   |:::|.||.|||::|:.||||.:||:|||||:|:|||:
Zfish  1828 VKWKYMISRAV----GKRLHSERIIGPGKEKCCYFFWQGRNSTVNEKGTSALMTVELDEERGAQV 1888

  Fly  4144 RVSQGDECTAFVRLFR-QMWQHRGRKEQCLER-HSEWRLYQLQGNVSEETIIKEVVCQSSHLRSR 4206
            :|.||.|...|::.|. .|..|.|::|:..:. .::||||.::|....|..:.|.||..|.||||
Zfish  1889 QVQQGKEPPCFLQCFNGGMIVHAGKREEEEDNTQNDWRLYCVRGEKPIEGHLLEAVCHCSSLRSR 1953

  Fly  4207 SSMLLIHGSQGNVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKD--LFSAETANLTEVEEGSDDDQ 4269
            :||:|::..:.::.:|||.|:..|||:|....|..:.:..|.:  |.|:...::.|.:||::...
Zfish  1954 TSMILLNIPKASLYLWHGCKAQVHTRDVGRTTANKIKEQCPLEAGLHSSSKVSIQECDEGAEPQG 2018

  Fly  4270 CKKALGLKDERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQL 4334
            ..:|||.:| |..|..:|:....|::..|:|..||..|.|.|:|...|.|..:|.:..||.|..|
Zfish  2019 FWEALGKRD-RKAYDCMLQDPGKFNFTPRLFQLSSASGEFAAVEFVYPSREPNLVNSMPFLQEDL 2082

  Fly  4335 YNARQPTIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGVNRWISERRAALETAVDYW 4399
            |.|.||.:||:|:..|::||.||||         :.|..|...|.   ||.|:|:.|:||.:.|.
Zfish  2083 YTATQPALFLVDNHHEVYLWQGWWP---------QDSESTGSARI---RWDSDRKCAMETVLQYS 2135

  Fly  4400 RAKHGENENE-PFHGIKGQVVWAGLEPLAFKALFPDWTERPDVREINEEDGRT-DASISIATMLA 4462
            :.|   ||.: |    |..::.||||||.|..:||.|..|.|:.||.|::... ...|.:..:|:
Zfish  2136 KEK---NEKKTP----KSYLIHAGLEPLTFTNMFPSWEHREDIAEITEKEAEVCHQIILVEDVLS 2193

  Fly  4463 QMTQTEYPLEVLKARPLPEGVEPTRLEVYLNAEDFQA-------ALGCSRAEFEQLPIWKQTKLK 4520
            ::.:|.|||..||||||||||:|.|||.||:.|||:.       ||..:|:|:|.||.|||..:|
Zfish  2194 RLCKTTYPLAELKARPLPEGVDPLRLETYLSDEDFEGVGASGKKALEMTRSEYEALPGWKQVNVK 2258

  Fly  4521 KERGLF 4526
            |.:|||
Zfish  2259 KAKGLF 2264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SvilNP_001286919.1 gelsolin_S2_like 3733..3825 CDD:200445 37/91 (41%)
gelsolin_like 3859..3965 CDD:200436 37/108 (34%)
ADF_gelsolin <4069..4158 CDD:301701 39/91 (43%)
gelsolin_S5_like 4176..4279 CDD:200444 35/104 (34%)
ADF_gelsolin 4328..4435 CDD:301701 43/107 (40%)
VHP 4492..4526 CDD:280388 17/40 (43%)
svilaXP_021335686.1 gelsolin_S2_like 1488..1584 CDD:200445 39/95 (41%)
gelsolin_like 1609..1709 CDD:200436 38/109 (35%)
gelsolin_S4_like 1792..1903 CDD:200449 47/115 (41%)
gelsolin_S5_like 1925..2028 CDD:200444 36/103 (35%)
ADF_gelsolin 2045..2166 CDD:326633 54/139 (39%)
VHP 2223..2264 CDD:308044 17/40 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1376537at2759
OrthoFinder 1 1.000 - - FOG0004673
OrthoInspector 1 1.000 - - otm25995
orthoMCL 1 0.900 - - OOG6_105657
Panther 1 1.100 - - LDO PTHR11977
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3618
SonicParanoid 1 1.000 - - X2758
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
98.950

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