DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and Vill

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001178546.2	Gene:	Vill / 301057	RGDID:	1304843	Length:	857	Species:	Rattus norvegicus

Alignment Length:	988	Identity:	211/988 - (21%)
Similarity:	339/988 - (34%)	Gaps:	283/988 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  3646 VQGPKGRRAARNPL-------KSLAAREDISSEYTEMRSGIAERELRRLKLESYGHNANLAAEAI 3703
            :..||..:.....|       .|..|:|...|....::..:.::.:  |..||.||.::......
  Rat    46 LHSPKATQGGSRDLHCWIGKEASTEAQEAAVSFMHRLQQDLGDQTV--LHRESQGHESDCFHSYF 108

  Fly  3704 --------AGLASVEDFKSVALRSSSIPLQQMWLPHKPVMLLHVKGRTHVQTRLVEPVHTSLNRG 3760
                    .|.||     ::.|..|::        :....|||::||.||....|.....|.|:|
  Rat   109 RPGVIYRKGGRAS-----ALKLGESNV--------YNVQRLLHIRGRKHVSATEVALSWNSFNKG 160

  Fly  3761 DCFILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVI-----LTDGKYLKERQ 3820
            |.|:|..|..:.::.|..|::.|.:|:..:..:: .:::.|..|...|:     .||...:.|
  Rat   161 DIFLLDLGKVMIQWNGPKASICEKARALSLTCSL-RDRERGGRAQIRVVDAENKATDLMSIME-- 222

  Fly  3821 WRQFWQLLGKKEDDQSDIAECGHADEDDVFESSLIETN-KIYE---------YQDEALIPLEKFW 3875
                 .:||::..     :.|.....:.|  |.|.:.| ::|.         .|:.|..||.:
  Rat   223 -----AVLGRRSG-----SLCASVPSNSV--SQLQKANIRLYHVFEKGTDLVVQELATRPLTQ-- 273

  Fly  3876 GCIPKVDMLDTRKVLVFDFGS-ELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLN 3939
                  |:|......:.|.|. ::|:|.|:.:..:.::||...|.....|:...:|.:..:
  Rat   274 ------DLLQEDGCYLLDQGGFKIYMWQGRKSSPEERKAAFSRAVGFIQAKGYPNYTNVEV---- 328

  Fly  3940 YVAIVGRRENTKYAKRCAQRPEWCVLGKITQNMETVLFKEKFSDWPEIEREDLEKDYLSNGVHMV 4004
                                        :....|:..|::.|..|.
  Rat   329 ----------------------------VNDGAESTAFQQLFWTWS------------------- 346

  Fly  4005 RALNGTALHKGEPYQEPNLVLEQANLGRGNFYYDTDTMRHFDVITKSTDK---WQIHEFNFDAAN 4066
            :.|||    |..|.|  :.:::|.||..|..:...:......::...:.|   |.|........:
  Rat   347 KELNG----KKHPRQ--SKLMQQVNLEVGKLHTQPELAAQLRMVDDGSGKVEVWYIQGSQRQPVD 405

  Fly  4067 NRDDYGHFYSAESYIVRWIYQISVTVRELSGKVSNRSTVGRDRCVYFTWQGQDSSANEKGAAALL 4131
            .: .:|...|...|:|.:.||                .:||.:.:.:.|||..|:..:..|....
  Rat   406 PK-HHGQLCSGNCYLVLYKYQ----------------KLGRVQYILYLWQGHQSTVEDVKALNCN 453

  Fly  4132 TVELD-KEKGA--QMRVSQGDECTAFVRLFR----QMWQHRGRKEQCLERHSEWRLYQLQGNVSE 4189
            ..||| ..:||  |..|:.|.|...|:.:|:    .:..:.|.|...|. .|:.||:.:||..|.
  Rat   454 AEELDLLHQGALVQGHVTMGREPPHFLAIFQGQLVVLQGNAGNKGGRLP-ISDTRLFHVQGTESH 517

  Fly  4190 ETIIKEVVCQSSHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKDLFSAE 4254
            .|...||..::|.|.|.....||  :.....:|.|.......|.    :|:.::...|.:
  Rat   518 NTRTMEVPARASSLTSSDVFFLI--TSHVCYLWFGKGCHGDQRE----MARTVVTVFPGN----- 571

  Fly  4255 TANLTEVEEGSDDDQCKKALGLKDERNEYGSLLKSTKSF-DYQIRIFNFSSTQGVFKALELSDPL 4318
              |...|.||.:.....:|||   .|..|.|..:..:.. ..|.|:|..||..|.....|:
  Rat   572 --NKETVLEGQEPLHFWEALG---GRAPYPSNKRLPEEISSIQPRLFECSSHSGHLVLTEV---- 627

  Fly  4319 RCQDLHSPYPFSQSQL--YNARQPTIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGV 4381
                    ..|.|..|  |:     |.|||...|::||:|                    ..||
  Rat   628 --------VFFGQEDLDKYD-----IMLLDTCQEIFLWLG--------------------EAAG- 658

  Fly  4382 NRWISERRAALETAVDYWRAKHGENE-NEPFHGIKGQVVWAGLEPLAFKALFPDW---------- 4435
             .|   ::||:....:|.|....|.. ..|.     .||..|.||..|...|..|
  Rat   659 -EW---KKAAVAWGHEYLRTHPAERSLATPI-----IVVKQGREPATFTGWFVTWDPYKWTSSQS 714

  Fly  4436 ---------------------------TERPDVREI----------------NE------EDGRT 4451
                                       |.||...|.                ||      .||.|
  Rat   715 YEEMVEGSLGPGSAISEITAEVHNFQLTARPSDSEAGRPTLLAFKGSQDSPENELELGLRVDGET 779

  Fly  4452 DASISIATMLAQMTQTEYPLEVL---KARPLPEGVEPTRLEVYLNAEDFQAALGCSRAEFEQLPI 4513
            .:....::..:.|.....|.|.|   ....||:||:|.|.|.||:..|||...|.|:.||..:..
  Rat   780 PSMNHTSSCSSSMINGSLPRERLMHQALEDLPQGVDPARKEFYLSDSDFQDIFGKSKEEFYSMAK 844

  Fly  4514 WKQTKLKKERGLF 4526
            |||.:.||:.|.|
  Rat   845 WKQQQEKKKLGFF 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	25/96 (26%)
		gelsolin_like	3859..3965	CDD:200436	17/115 (15%)
		ADF_gelsolin	<4069..4158	CDD:301701	23/91 (25%)
		gelsolin_S5_like	4176..4279	CDD:200444	26/102 (25%)
		ADF_gelsolin	4328..4435	CDD:301701	28/109 (26%)
		VHP	4492..4526	CDD:280388	14/33 (42%)
Vill	NP_001178546.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920