DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Svil and Capg

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001013104.1	Gene:	Capg / 297339	RGDID:	1311724	Length:	349	Species:	Rattus norvegicus

Alignment Length:	378	Identity:	76/378 - (20%)
Similarity:	132/378 - (34%)	Gaps:	150/378 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  3638 ERLVSKRHVQG----------PKGRRAARNPLKSLAARE-DISSEYTEMRSGIAERELRRLKLES 3691
            ||.|..|.|||          |:|          |..|| .:.|.:.:..||.....:|:
  Rat    90 ERPVQHREVQGNESDLFMSYFPQG----------LKYREGGVESAFHKTTSGTTPAAIRK----- 139

  Fly  3692 YGHNANLAAEAIAGLASVEDFKSVALRSSSIPLQQMWLPHKPVMLLHVKGRTHVQTRLVEPVHTS 3756
                                                        |..|||:.:::.........|
  Rat   140 --------------------------------------------LYQVKGKKNIRATERALSWDS 160

  Fly  3757 LNRGDCFILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVILTDGKYLKERQW 3821
            .|.||||||..|..:|.:.|..:|::|.::::.:..||.:::..|  ..|..|:|||:     :.
  Rat   161 FNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQG--KAQVEIITDGE-----EP 218

  Fly  3822 RQFWQLLGKKEDDQSDIAECGHADEDDVFESSLIETNKIYEYQD------------------EAL 3868
            .:..|:||.|     ...:.|:.:||...:.:..:...:|:..|                  |.|
  Rat   219 AEMIQVLGPK-----PALKEGNPEEDITADQTNAQAAALYKVSDATGQMNLTKVADSSPFASELL 278

  Fly  3869 IPLEKFWGCIPKVDMLDTRKVLVFDFG--SELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYA 3931
            ||.:.|                |.|.|  .::|:|.|:.|....::||:::             |
  Rat   279 IPDDCF----------------VLDNGLCGKIYIWKGRKANEKERQAALQV-------------A 314

  Fly  3932 DCYLNPLNYVAIVGRRENTKYAKRCAQRPEWCVLGKITQNMETVLFKEKFSDW 3984
            |.:::.:.|      ..||:             :..:.|..|:.:||:.|.||
  Rat   315 DGFISRMRY------SPNTQ-------------VEILPQGRESPIFKQFFKDW 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	25/91 (27%)
		gelsolin_like	3859..3965	CDD:200436	21/125 (17%)
		ADF_gelsolin	<4069..4158	CDD:301701
		gelsolin_S5_like	4176..4279	CDD:200444
		ADF_gelsolin	4328..4435	CDD:301701
		VHP	4492..4526	CDD:280388
Capg	NP_001013104.1	gelsolin_S1_like	17..120	CDD:200446	12/39 (31%)
		Gelsolin-like 1	28..107		7/16 (44%)
		Nuclear localization signal. /evidence=ECO:0000255	138..147		5/57 (9%)
		gelsolin_S2_like	139..226	CDD:200445	26/142 (18%)
		Gelsolin-like 2	147..222		21/81 (26%)
		gelsolin_S3_like	247..347	CDD:200448	26/147 (18%)
		Gelsolin-like 3	264..342		21/125 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010