DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and Gsn

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001004080.1	Gene:	Gsn / 296654	RGDID:	1303089	Length:	780	Species:	Rattus norvegicus

Alignment Length:	963	Identity:	208/963 - (21%)
Similarity:	349/963 - (36%)	Gaps:	266/963 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  3536 STSKSALRSLSVNPEEEGPTSLSRSN-SSSSESDGERKSPQNAKQNKELANNKSAAAPTNVGARI 3599
            |:.:|||..|::       .:||.|: :::|....:.::||         :..|...|:.:  .:
  Rat     6 SSLRSALLVLAL-------CALSPSHAATASRGRAQERAPQ---------SRVSETRPSTM--VV 52

  Fly  3600 QVPRLDDKETFENFFSSKPKKEENVQL-EISAFD----------DIKPTERLVSKRHVQGPKGRR 3653
            :.|..           .|..||..:|: .:..||          |....:..|..:.||
  Rat    53 EHPEF-----------LKAGKEPGLQIWRVEKFDLVPVPPNLYGDFFTGDAYVILKTVQ------ 100

  Fly  3654 AARNPLKSLAAREDISSEYTEMRSGIAERELRRLKLESYGHNANLAAEAIAGLAS---------- 3708
             .||..........:.:|.::..||.|  .:..::|:.|.:...:....:.|..|
  Rat   101 -LRNGNLQYDLHYWLGNECSQDESGAA--AIFTVQLDDYLNGRAVQHREVQGFESSTFQGYFKSG 162

  Fly  3709 --------VEDFKSVALRSSSIPLQQMWLPHKPVM--LLHVKGRTHVQTRLVEPVHTSLNRGDCF 3763
                    ...||.|             :|::.|:  |..||||..|:...|.....|.|.||||
  Rat   163 LKYKKGGVASGFKHV-------------VPNEVVVQRLFQVKGRRVVRATEVPVSWDSFNNGDCF 214

  Fly  3764 ILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVILTDGKYLKERQWRQFWQLL 3828
            ||..|:.::::.||.:|..|..::.::...|.:|:..|  ..|..:..:|.     :.....|:|
  Rat   215 ILDLGNNIYQWCGSGSNKFERLKATQVSKGIRDNERSG--RAQVHVSEEGS-----EPEAMLQVL 272

  Fly  3829 GKKED---DQSDIAECGHADEDDVFESSLIETNKIYEYQDE------ALIPLEKFWGCIPKVDML 3884
            |.|.|   ...|.|      ::|.....|.   |:|:..:.      :|:..|..:.    ...|
  Rat   273 GPKPDLPQGTEDTA------KEDAANRRLA---KLYKVSNSGGSMSVSLVADENPFA----QSAL 324

  Fly  3885 DTRKVLVFDFG--SELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRR 3947
            .:....:.|.|  .:::||.||.|..|.::||::.|.:             :::.:.|
  Rat   325 RSEDCFILDHGRDGKIFVWKGKQANMDERKAALKTASD-------------FISKMQY------- 369

  Fly  3948 ENTKYAKRCAQRPEWCVLGKITQNMETVLFKEKFSDWPEIERED-LEKDYLSNGVHMVRALNGTA 4011
                        |....:..:.:..||.|||:.|.:|.:.::.| ....|||:.:..|..:
  Rat   370 ------------PRQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGPGLSYLSSHIANVERV---- 418

  Fly  4012 LHKGEPYQEPNLVLEQANLGRGNFYYDTDTMRHFDVITKSTDKWQIHEFN---FDAANNRDDYGH 4073
                 |:....|....|...:...  |.|.       |.....|:|...|   .|.|.    ||.
  Rat   419 -----PFDAATLHTSTAMAAQHGM--DDDG-------TGQKQIWRIEGSNKVLVDPAT----YGQ 465

  Fly  4074 FYSAESYIVRWIYQISVTVRELSGKVSNRSTVGRDRCVYFTWQGQDSSANEKGAAALLTVELDKE 4138
            ||..:|||:.:.|:..                ||...:.:.|||..|:.:|..|:|:||.:||:|
  Rat   466 FYGGDSYIILYNYRHG----------------GRQGQIIYNWQGAQSTQDEVAASAILTAQLDEE 514

  Fly  4139 KG---AQMRVSQGDECTAFVRLF--RQMWQHRG--RKEQCLERHSEWRLYQLQGNVSEETIIKEV 4196
            .|   .|.||.||.|....:.||  :.|..::|  .::......:..||:|::.:.|..|...||
  Rat   515 LGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSRDGGQTTPASTRLFQVRASSSGATRAVEV 579

  Fly  4197 VCQSSHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTRNVAVGV-AQDLIKTVPKDLFSAETANLTE 4260
            :.::..|.|..:.:|               ..|....:.||. |.|..||...:|.....|...:
  Rat   580 MPKAGALNSNDAFVL---------------KTPSAAYLWVGTGASDAEKTGALELLKVLRAQHVQ 629

  Fly  4261 VEEGSDDDQCKKALGLKDERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKALELSDPLRCQDLHS 4325
            |||||:.|...:|||.|..... ...||..|...:..|:|..|:..|.|...|:...|..:||.:
  Rat   630 VEEGSEPDGFWEALGGKTAYRT-SPRLKDKKMDAHPPRLFACSNRIGRFVIEEVPGELMQEDLAT 693

  Fly  4326 PYPFSQSQLYNARQPTIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGVNRWIS---- 4386
                          ..:.|||..|::::|:|          .|.:.....|......|:|.
  Rat   694 --------------DDVMLLDTWDQVFVWVG----------KDSQEEEKTEALTSAKRYIETDPA 734

  Fly  4387 --ERRAALETAVDYWRAKHGENENEPFHGIKGQVVWAGLEPLAFKALFPDWTE 4437
              :||..:                        .||..|.||.:|...|..|.:
  Rat   735 NRDRRTPI------------------------TVVRQGFEPPSFVGWFLGWDD 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	26/93 (28%)
		gelsolin_like	3859..3965	CDD:200436	18/113 (16%)
		ADF_gelsolin	<4069..4158	CDD:301701	29/91 (32%)
		gelsolin_S5_like	4176..4279	CDD:200444	29/103 (28%)
		ADF_gelsolin	4328..4435	CDD:301701	19/112 (17%)
		VHP	4492..4526	CDD:280388
Gsn	NP_001004080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..48		4/28 (14%)
		Actin-severing. /evidence=ECO:0000255	51..174		21/142 (15%)
		gelsolin_S1_like	57..169	CDD:200446	20/131 (15%)
		Actin-actin interfilament contact point. /evidence=ECO:0000250	121..124		0/2 (0%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	160..167		0/6 (0%)
		gelsolin_S2_like	184..273	CDD:200445	26/95 (27%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	186..194		4/7 (57%)
		Gelsolin-like 2	196..236		15/39 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..286		11/48 (23%)
		gelsolin_S3_like	296..393	CDD:200448	24/135 (18%)
		Gelsolin-like 3	312..354		11/45 (24%)
		Actin-binding, Ca-sensitive. /evidence=ECO:0000255	432..780		102/425 (24%)
		gelsolin_S4_like	437..537	CDD:200449	37/128 (29%)
		gelsolin_S5_like	559..647	CDD:200444	28/102 (27%)
		gelsolin_S6_like	664..762	CDD:200447	28/145 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920