DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and GSN

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_000168.1	Gene:	GSN / 2934	HGNCID:	4620	Length:	782	Species:	Homo sapiens

Alignment Length:	962	Identity:	205/962 - (21%)
Similarity:	348/962 - (36%)	Gaps:	267/962 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  3525 SMMVTSSTSTNSTSKSALRSLSVNPEEEGPTSLSRSNSSSSESDGERKSPQNAKQNKELANNKSA 3589
            |:.|.::|::...|::.        ..:|....:|.||...|      .|:..|..||
Human    22 SLPVRAATASRGASQAG--------APQGRVPEARPNSMVVE------HPEFLKAGKE------- 65

  Fly  3590 AAPTNVGARIQVPRLDDKETFENFFSSKPKKEENVQLEISAFDDIKPTERLVSKRHVQGPKGRRA 3654
                   ..:|:.|::              |.:.|.:..:.:.|....:..|..:.||
Human    66 -------PGLQIWRVE--------------KFDLVPVPTNLYGDFFTGDAYVILKTVQ------- 102

  Fly  3655 ARNPLKSLAAREDISSEYTEMRSGIAERELRRLKLESYGHNANLAAEAIAGLAS----------- 3708
            .||..........:.:|.::..||.|  .:..::|:.|.:...:....:.|..|
Human   103 LRNGNLQYDLHYWLGNECSQDESGAA--AIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGL 165

  Fly  3709 -------VEDFKSVALRSSSIPLQQMWLPHKPVM--LLHVKGRTHVQTRLVEPVHTSLNRGDCFI 3764
                   ...||.|             :|::.|:  |..||||..|:...|.....|.|.|||||
Human   166 KYKKGGVASGFKHV-------------VPNEVVVQRLFQVKGRRVVRATEVPVSWESFNNGDCFI 217

  Fly  3765 LVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVILTDGKYLKERQWRQFWQLLG 3829
            |..|:.:.::.||.:|..|..::.::...|.:|:..|.....  :..:|     .:.....|:||
Human   218 LDLGNNIHQWCGSNSNRYERLKATQVSKGIRDNERSGRARVH--VSEEG-----TEPEAMLQVLG 275

  Fly  3830 KKEDDQSDIAECGHAD--EDDVFESSLIETNKIYEYQDEA------LIPLEKFW--GCIPKVDML 3884
            .|     .....|..|  ::|.....|.   |:|:..:.|      |:..|..:  |.:...|
Human   276 PK-----PALPAGTEDTAKEDAANRKLA---KLYKVSNGAGTMSVSLVADENPFAQGALKSED-- 330

  Fly  3885 DTRKVLVFDFGSE--LYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRR 3947
                ..:.|.|.:  ::||.||.|.::.::||::.|.:             ::..::|
Human   331 ----CFILDHGKDGKIFVWKGKQANTEERKAALKTASD-------------FITKMDY------- 371

  Fly  3948 ENTKYAKRCAQRPEWCVLGKITQNMETVLFKEKFSDWPEIERED-LEKDYLSNGVHMVRALNGTA 4011
                        |:...:..:.:..||.|||:.|.:|.:.::.| |...|||:.:..|..:
Human   372 ------------PKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVERV---- 420

  Fly  4012 LHKGEPYQEPNLVLEQANLGRGNFYYDTDTMRHFDVITKSTDKWQIHEFN---FDAANNRDDYGH 4073
                 |:....|....|...:...  |.|.       |.....|:|...|   .|.|.    ||.
Human   421 -----PFDAATLHTSTAMAAQHGM--DDDG-------TGQKQIWRIEGSNKVPVDPAT----YGQ 467

  Fly  4074 FYSAESYIVRWIYQISVTVRELSGKVSNRSTVGRDRCVYFTWQGQDSSANEKGAAALLTVELDKE 4138
            ||..:|||:.:.|:..                ||...:.:.|||..|:.:|..|:|:||.:||:|
Human   468 FYGGDSYIILYNYRHG----------------GRQGQIIYNWQGAQSTQDEVAASAILTAQLDEE 516

  Fly  4139 KG---AQMRVSQGDECTAFVRLF--RQMWQHRG--RKEQCLERHSEWRLYQLQGNVSEETIIKEV 4196
            .|   .|.||.||.|....:.||  :.|..::|  .:|......:..||:|::.|.:..|...||
Human   517 LGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEV 581

  Fly  4197 VCQSSHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKDLFSAETANLTEV 4261
            :.::..|.|..:.:|...|...:.|..|:..|..|.      ||:|::.:        .|...:|
Human   582 LPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTG------AQELLRVL--------RAQPVQV 632

  Fly  4262 EEGSDDDQCKKALGLKDERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKALELSDPLRCQDLHSP 4326
            .|||:.|...:|||.| ........||..|...:..|:|..|:..|.|...|:...|..:||.:
Human   633 AEGSEPDGFWEALGGK-AAYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLAT- 695

  Fly  4327 YPFSQSQLYNARQPTIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGVNRWIS----- 4386
                         ..:.|||..|::::|:|          .|.:.....|......|:|.
Human   696 -------------DDVMLLDTWDQVFVWVG----------KDSQEEEKTEALTSAKRYIETDPAN 737

  Fly  4387 -ERRAALETAVDYWRAKHGENENEPFHGIKGQVVWAGLEPLAFKALFPDWTE 4437
             :||..:                        .||..|.||.:|...|..|.:
Human   738 RDRRTPI------------------------TVVKQGFEPPSFVGWFLGWDD 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	25/93 (27%)
		gelsolin_like	3859..3965	CDD:200436	19/115 (17%)
		ADF_gelsolin	<4069..4158	CDD:301701	29/91 (32%)
		gelsolin_S5_like	4176..4279	CDD:200444	28/102 (27%)
		ADF_gelsolin	4328..4435	CDD:301701	19/112 (17%)
		VHP	4492..4526	CDD:280388
GSN	NP_000168.1	Actin-severing. /evidence=ECO:0000255	53..176		23/165 (14%)
		gelsolin_S1_like	59..171	CDD:200446	21/148 (14%)
		Actin-actin interfilament contact point	123..126		0/2 (0%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	162..169		0/6 (0%)
		gelsolin_S2_like	186..275	CDD:200445	25/95 (26%)
		Polyphosphoinositide binding. /evidence=ECO:0000250	188..196		4/7 (57%)
		Gelsolin-like 2	198..238		15/39 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..285		9/49 (18%)
		gelsolin_S3_like	295..395	CDD:200448	26/140 (19%)
		Gelsolin-like 3	314..356		11/47 (23%)
		Actin-binding, Ca-sensitive. /evidence=ECO:0000255	434..782		102/424 (24%)
		gelsolin_S4_like	439..539	CDD:200449	37/128 (29%)
		gelsolin_S5_like	561..649	CDD:200444	28/102 (27%)
		gelsolin_S6_like	666..764	CDD:200447	28/145 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920