DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and Flii

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_001008280.1	Gene:	Flii / 287375	RGDID:	1307590	Length:	1270	Species:	Rattus norvegicus

Alignment Length:	1442	Identity:	281/1442 - (19%)
Similarity:	493/1442 - (34%)	Gaps:	444/1442 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  3202 ENSTPKHDDAVSLVRNLSTLGQPRSLARDDAAGNCASASEGESSGGREIEAIIKNSAVARRRRQQ 3266
            |:.:..|::..:|...||:|...|::.        |.|:..::||..:....:.:.:|......|
  Rat    59 EHLSVSHNNLTTLHGELSSLPSLRAIV--------ARANSLKNSGVPDDIFKLDDLSVLDLSHNQ 115

  Fly  3267 QQQSQQQNQPDGNLVAKSKSHSGI-SAP----IGLG------------PQLPPLPLGGGFVKLRH 3314
            ..:..::.:...|::..:.||:.| |.|    |.|.            ..|||        ::|.
  Rat   116 LTECPRELENAKNMLVLNLSHNSIDSIPNQLFINLTDLLYLDLSENRLESLPP--------QMRR 172

  Fly  3315 VAKEEDTSSSSNT---SSAKESP-----DKKDLRQEQAEASGDSSHPTALPQFLQGVQRSSTEVM 3371
            :...:....:.|.   :..::.|     ....||..|...|.       ||..|:|:...|...:
  Rat   173 LVHLQTLVLNGNPLLHAQLRQLPAMMALQTLHLRNTQRTQSN-------LPTSLEGLSNLSDVDL 230

  Fly  3372 G--------------PDQRSLVISKTGSIAERLAALHKSGEDDWKKRISKRDEVDDVHRENF--- 3419
            .              |:...|.:| :..|||....:     |.|            ||.|..
  Rat   231 SCNDLTRVPECLYTLPNLHRLNLS-SNQIAELSLCI-----DQW------------VHLETLNLS 277

  Fly  3420 VNESLSL----------------AHSLSDKPLPPS-----------------PLIPTSLEGGKVS 3451
            .|:..||                ::.|....||..                 .|||.||
  Rat   278 RNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLPSGIGKLTSLEEFMAANNNLELIPESL------ 336

  Fly  3452 DRLSKLKCNSENWKQRIEQTDAKKFTVAGRLQKKAQSPVELQFERSANDAAKKCPMLEVRSANQP 3516
            .|..||:....|..:.:...:|..|.....:....::|..:...:.|:..|:   ...:..:.|.
  Rat   337 CRCPKLRKLVLNKNRLVTLPEAIHFLTEIEVLDVRENPSLVMPPKPADHTAE---WYNIDFSLQN 398

  Fly  3517 QLGLAKSPSMMVTSSTSTNSTSKSAL-RSLSVNPEEEGPTSLSRSNSSSSESDGERKSPQNAKQN 3580
            ||.||.:....|.::.:..|.||..| |.:.:...::....:.........||..:      ::|
  Rat   399 QLRLAGASPATVAAAAAVGSGSKDPLARKMRLRRRKDSAQDVQAKQVLKGMSDVAQ------EKN 457

  Fly  3581 KELANNKSAAAPTNVGAR----IQVPRLDDKETF---------------ENF--------FSSKP 3618
            |....:..|.||.....|    ::.||||..|.|               |||        |..|
  Rat   458 KNQEESTDARAPGGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGK- 521

  Fly  3619 KKEENVQLEISAF-DDIKPTE---------------------RLVSKRHVQGPKGRRAARNPLKS 3661
            ..|.:..:.:..| ||.....                     ..|:.|:..|.:.|
  Rat   522 FYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECR--------- 577

  Fly  3662 LAAREDISSEYTEMRSGIAERELRRLKLESYGHNANLAAEAIAGLASVEDFKSVALRSSSIPLQQ 3726
             .|||::..| :|....:.:.::      ||     :.....:|..:|||
  Rat   578 -TAREEMGDE-SEGFLQVFDNDI------SY-----IEGGTASGFYTVED--------------- 614

  Fly  3727 MWLPHKPVMLLHVKGRTHVQTRLVEPV---HTSLNRGDCFILVAGSQLFRYVGSFANVIEISRSK 3788
               .|....:..|.|:.:::   :|||   .|||:....|:|..|..::.:.|:.|.:...::::
  Rat   615 ---THYVTRMYRVYGKKNIK---LEPVPLKGTSLDPRFVFLLDQGLDIYVWRGAQATLSNTTKAR 673

  Fly  3789 KICAAIVENKDLGCTATQEVILTDGKYLKERQWRQFWQLLGKKEDDQSDIAECGHADED------ 3847
            .....:.:|:..|  ..:..:|..|:...|     ||.:||   .:.|:|.:  |..:|
  Rat   674 LFAEKMNKNERKG--KAEITLLVQGQEPPE-----FWDVLG---GEPSEIKK--HVPDDFWPPQP 726

  Fly  3848 ---------DVFESSLIETNKIYEYQDEALIPLEKFWGCIPKVD----------MLDTRKVLVFD 3893
                     ...|...|......|::..            |||:          :||||.|.:.|
  Rat   727 KLYKVGLGLGYLELPQINYKLSVEHKKR------------PKVELMPGMRLLQSLLDTRCVYILD 779

  Fly  3894 FGSELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTKYAKRCAQ 3958
            ..|::::|.|:.:|...:.||::|.||..|                                ...
  Rat   780 CWSDVFIWLGRKSPRLVRAAALKLGQELCG--------------------------------MLH 812

  Fly  3959 RPEWCVLGKITQNMETVLFKEKFSDWPEIEREDLEKDYLSNGVHMVR--ALNGTALHKGE----- 4016
            ||...|:.:..:..|..:||.||.:|.::    |..||..|...:::  .::|......|
  Rat   813 RPRHTVVSRSLEGTEAQVFKAKFKNWDDV----LTVDYTRNAEAVLQGPGISGKVKRDTEKKDQM 873

  Fly  4017 ---------PYQEPNLVLEQANLGRGNFYYDTDTMRHFDVITKSTDKWQIHEFNFDAANNRDDYG 4072
                     |.|.| :.|.:|......:..|.|.|..|  :.:.....::.|         :::|
  Rat   874 KADLTALFLPRQPP-MPLAEAEQLMEEWNEDLDGMEGF--VLEGRKFTRLAE---------EEFG 926

  Fly  4073 HFYSAESYIVRWIYQISVTVRE---LSGKVSNRSTVGRD-----------------RCVYFTWQG 4117
            |||:.:.|:....|.:.|...|   ...|....|..||:                 :|:.:.|||
  Rat   927 HFYTQDCYVFLCRYWVPVEYEEEEKPEDKEGKASAEGREEEEAAAETEEKQPEEDFQCIVYFWQG 991

  Fly  4118 QDSSANEKGAAALLTVELDKE-------KGAQMRVSQGDECTAFVRLF-RQMWQHRGRKE--QCL 4172
            :::|   .......|..|.|:       |...:|::|..|...|:..| |:...|||:::  |.|
  Rat   992 REAS---NMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRKVTQTL 1053

  Fly  4173 ERHSEWRLYQLQGNVSEE-TIIKEVVCQSSHLRSRSSMLL-----IHGSQGNVIVWHGSKSAPHT 4231
            :.    .|||::.|.|.. |...::...||.|.|....:|     ...:||.|..|.|..|.|..
  Rat  1054 QP----TLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDE 1114

  Fly  4232 RNVAVGVAQDLIKTVPKDLFSAETANLTEVEEGSDDDQ-CKKALGLKDERNEYGSLLKSTKSFDY 4295
            ..    :|:|::.|:....:|.:..|     ||.:.:. ....:|.:...::....:|.|
  Rat  1115 AK----LAEDILNTMFDPSYSKQVIN-----EGEEPENFFWVGIGAQKPYDDDAEYMKHT----- 1165

  Fly  4296 QIRIFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQLYNARQPTIFLLDDGDELWLWMGWWPL 4360
              |:|..|:.:|.|...|     :|.|      |.|..|   ....|.|||:|.|:::|:|....
  Rat  1166 --RLFRCSNEKGYFAVTE-----KCSD------FCQDDL---ADDDIMLLDNGQEVYMWVGTQTS 1214

  Fly  4361 E-DVKINTDERSSPTNENRAGVNRWISERRAALETAVDYWRAKHGENENEPFHGIKGQVVWAGLE 4424
            : ::|::.                      .|.:..:.:.|:|..|...      :.::|..|.|
  Rat  1215 QVEIKLSL----------------------KACQVYIQHTRSKEHERPR------RLRLVRKGNE 1251

  Fly  4425 PLAFKALFPDWT 4436
            ..||...|..|:
  Rat  1252 QRAFTRCFHAWS 1263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	18/94 (19%)
		gelsolin_like	3859..3965	CDD:200436	22/115 (19%)
		ADF_gelsolin	<4069..4158	CDD:301701	25/115 (22%)
		gelsolin_S5_like	4176..4279	CDD:200444	26/109 (24%)
		ADF_gelsolin	4328..4435	CDD:301701	22/107 (21%)
		VHP	4492..4526	CDD:280388
Flii	NP_001008280.1	LRR_RI	<2..139	CDD:238064	16/87 (18%)
		leucine-rich repeat	10..34	CDD:275380
		LRR_8	33..91	CDD:290566	9/39 (23%)
		leucine-rich repeat	35..57	CDD:275380
		leucine-rich repeat	58..80	CDD:275380	6/20 (30%)
		leucine-rich repeat	83..105	CDD:275380	4/29 (14%)
		LRR_RI	89..375	CDD:238064	55/324 (17%)
		leucine-rich repeat	106..128	CDD:275380	2/21 (10%)
		leucine-rich repeat	129..152	CDD:275380	7/22 (32%)
		LRR_8	131..186	CDD:290566	12/62 (19%)
		leucine-rich repeat	153..175	CDD:275380	4/29 (14%)
		leucine-rich repeat	176..199	CDD:275380	2/22 (9%)
		leucine-rich repeat	200..224	CDD:275380	8/30 (27%)
		LRR_8	223..281	CDD:290566	13/75 (17%)
		leucine-rich repeat	225..247	CDD:275380	1/21 (5%)
		leucine-rich repeat	248..270	CDD:275380	7/39 (18%)
		LRR_8	270..352	CDD:290566	17/87 (20%)
		leucine-rich repeat	271..318	CDD:275380	7/46 (15%)
		leucine-rich repeat	319..341	CDD:275380	6/27 (22%)
		gelsolin_S1_like	492..604	CDD:200446	20/134 (15%)
		gelsolin_like	619..703	CDD:200436	18/93 (19%)
		gelsolin_S3_like	723..837	CDD:200448	30/157 (19%)
		gelsolin_like	<976..1036	CDD:200436	13/62 (21%)
		gelsolin_S5_like	1054..1153	CDD:200444	26/111 (23%)
		gelsolin_S6_like	1164..1263	CDD:200447	31/147 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920