DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and Gsn

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	XP_006498053.1	Gene:	Gsn / 227753	MGIID:	95851	Length:	802	Species:	Mus musculus

Alignment Length:	958	Identity:	209/958 - (21%)
Similarity:	348/958 - (36%)	Gaps:	249/958 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  3541 ALRSLSVNPEEEGPTSLSRSNSSSSESDGERKSPQNAKQNKELANNKSAAAPTNVGARIQVPRLD 3605
            ||.:||  |.....||..|:         :.::||:......::......:|:|......|....
Mouse    16 ALCALS--PSHAATTSRGRA---------QERAPQSRVSEARVSARGPRGSPSNCLLFCPVSLQP 69

  Fly  3606 DKETFENFFSSKPKKEENVQL-EISAFD----------DIKPTERLVSKRHVQGPKGRRAARNPL 3659
            .....|:....|..||..:|: .:..||          |....:..|..:.||       .||..
Mouse    70 STMVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPPNLYGDFFTGDAYVILKTVQ-------LRNGN 127

  Fly  3660 KSLAAREDISSEYTEMRSGIAERELRRLKLESYGHNANLAAEAIAGLAS---------------- 3708
            ........:.:|.::..||.|  .:..::|:.|.:...:....:.|..|
Mouse   128 LQYDLHYWLGNECSQDESGAA--AIFTVQLDDYLNGRAVQHREVQGFESSTFSGYFKSGLKYKKG 190

  Fly  3709 --VEDFKSVALRSSSIPLQQMWLPHKPVM--LLHVKGRTHVQTRLVEPVHTSLNRGDCFILVAGS 3769
              ...||.|             :|::.|:  |..||||..|:...|.....|.|.||||||..|:
Mouse   191 GVASGFKHV-------------VPNEVVVQRLFQVKGRRVVRATEVPVSWDSFNNGDCFILDLGN 242

  Fly  3770 QLFRYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVILTDGKYLKERQWRQFWQLLGKK--- 3831
            .::::.||.:|..|..::.::...|.:|:..|  ..|..:..:|     .:.....|:||.|
Mouse   243 NIYQWCGSGSNKFERLKATQVSKGIRDNERSG--RAQVHVSEEG-----GEPEAMLQVLGPKPAL 300

  Fly  3832 EDDQSDIAECGHADEDDVFESSLIETNKIYEYQDEA------LIPLEKFW--GCIPKVDMLDTRK 3888
            .:...|.|      ::|.....|.   |:|:..:.|      |:..|..:  |.:...|
Mouse   301 PEGTEDTA------KEDAANRRLA---KLYKVSNGAGSMSVSLVADENPFAQGALRSED------ 350

  Fly  3889 VLVFDFG--SELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTK 3951
            ..:.|.|  .:::||.||.|..:.::||::.|.:             :::.:.|
Mouse   351 CFILDHGRDGKIFVWKGKQANMEERKAALKTASD-------------FISKMQY----------- 391

  Fly  3952 YAKRCAQRPEWCVLGKITQNMETVLFKEKFSDWPEIERED-LEKDYLSNGVHMVRALNGTALHKG 4015
                    |....:..:.:..||.|||:.|.:|.:.::.| ....|||:.:..|..:
Mouse   392 --------PRQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGPGLGYLSSHIANVERV-------- 440

  Fly  4016 EPYQEPNLVLEQANLGRGNFYYDTDTMRHFDVITKSTDKWQIHEFN---FDAANNRDDYGHFYSA 4077
             |:....|....|...:...  |.|.       |.....|:|...|   .|.|.    ||.||..
Mouse   441 -PFDAATLHTSTAMAAQHGM--DDDG-------TGQKQIWRIEGSNKVPVDPAT----YGQFYGG 491

  Fly  4078 ESYIVRWIYQISVTVRELSGKVSNRSTVGRDRCVYFTWQGQDSSANEKGAAALLTVELDKEKG-- 4140
            :|||:.:.|:..                ||...:.:.|||..|:.:|..|:|:||.:||:|.|
Mouse   492 DSYIILYNYRHG----------------GRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGT 540

  Fly  4141 -AQMRVSQGDECTAFVRLF--RQMWQHRG--RKEQCLERHSEWRLYQLQGNVSEETIIKEVVCQS 4200
             .|.||.||.|....:.||  :.|..::|  .::......:..||:|::.:.|..|...||:.:|
Mouse   541 PVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSRDGGQTAPASIRLFQVRASSSGATRAVEVMPKS 605

  Fly  4201 SHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKDLFSAETANLTEVEEGS 4265
            ..|.|..:.:|...|...:.|..|:..|..|.      ||:|:|.:        .:...:|||||
Mouse   606 GALNSNDAFVLKTPSAAYLWVGAGASEAEKTG------AQELLKVL--------RSQHVQVEEGS 656

  Fly  4266 DDDQCKKALGLKDERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKALELSDPLRCQDLHSPYPFS 4330
            :.|...:|||.|..... ...||..|...:..|:|..|:..|.|...|:...|..:||.:
Mouse   657 EPDAFWEALGGKTAYRT-SPRLKDKKMDAHPPRLFACSNRIGRFVIEEVPGELMQEDLAT----- 715

  Fly  4331 QSQLYNARQPTIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGVNRWIS------ERR 4389
                     ..:.|||..|::::|:|          .|.:.....|......|:|.      :||
Mouse   716 ---------DDVMLLDTWDQVFVWVG----------KDSQEEEKTEALTSAKRYIETDPANRDRR 761

  Fly  4390 AALETAVDYWRAKHGENENEPFHGIKGQVVWAGLEPLAFKALFPDWTE 4437
            ..:                        .||..|.||.:|...|..|.:
Mouse   762 TPI------------------------TVVRQGFEPPSFVGWFLGWDD 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	26/93 (28%)
		gelsolin_like	3859..3965	CDD:200436	19/115 (17%)
		ADF_gelsolin	<4069..4158	CDD:301701	29/91 (32%)
		gelsolin_S5_like	4176..4279	CDD:200444	30/102 (29%)
		ADF_gelsolin	4328..4435	CDD:301701	19/112 (17%)
		VHP	4492..4526	CDD:280388
Gsn	XP_006498053.1	gelsolin_S1_like	79..191	CDD:200446	20/120 (17%)
		gelsolin_S2_like	206..295	CDD:200445	26/95 (27%)
		gelsolin_S3_like	318..415	CDD:200448	25/137 (18%)
		gelsolin_S4_like	459..559	CDD:200449	37/128 (29%)
		gelsolin_S5_like	581..669	CDD:200444	29/101 (29%)
		gelsolin_S6_like	686..784	CDD:200447	28/145 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920