DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Svil and Svil

DIOPT Version :9

Sequence 1:NP_001286919.1 Gene:Svil / 38306 FlyBaseID:FBgn0266696 Length:4526 Species:Drosophila melanogaster
Sequence 2:XP_006525852.1 Gene:Svil / 225115 MGIID:2147319 Length:2187 Species:Mus musculus


Alignment Length:2572 Identity:708/2572 - (27%)
Similarity:1066/2572 - (41%) Gaps:644/2572 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  2179 EEQRNRYSSPVSPKASSNGGVQAQRRLSNSELSPKSPG----------ASGFTSEPVASATANRV 2233
            ||...||.....|.:...|..:.:.....|.|..::|.          :||........:.|.|:
Mouse    36 EEDTPRYMRATDPASPHIGRSKEEEDTPGSSLEKQTPSKYCIETSGIHSSGSMDTHSLESKAERI 100

  Fly  2234 PTRSASHPVDTPPTQRRQPLVAVSSGISMKQSLSELHFTGGAVSPPKATAECTLRMRPRSSTMST 2298
            ....|.        :|||              |:|.:   |....|:|.:|              
Mouse   101 ARYKAE--------RRRQ--------------LAEKY---GLTLDPEADSE-------------- 126

  Fly  2299 ENTENGRRDHLANLQLSPVQKQKRTPEVSPRRFGDRDKSAKRKSNLNRSLTEEATKDGDEVASST 2363
                          .||...|.::.|:|:.|| |..||.            ||.:||.:.     
Mouse   127 --------------YLSRYAKSRKDPDVTERR-GKSDKQ------------EEQSKDANS----- 159

  Fly  2364 RRRRRRELGMARPLVPGDDDALRDLLTPQKSSCSESTNSISEPHLQFIPAVRHPVVPVRTMTAVL 2428
             |..|.|.|....||...|      .||..|:.|:....:                         
Mouse   160 -RHSRTESGPRTSLVASQD------CTPLGSNMSDQEQLL------------------------- 192

  Fly  2429 PAPRPLHTPAARNVSQKFNERTKTD--LAEIKKIAEQSEAQVQQPSVDDNQKM---SAIMRRKST 2488
                        ||.   |:|...|  |.|....|..||..:..|.|..:.|.   |.:.:..|.
Mouse   193 ------------NVE---NQRRVQDPPLGEDGSSAFFSERSISFPEVPRSPKQIPSSPLQQPASP 242

  Fly  2489 DEGGSALGATNQNSPPAPNQIVSILKKKEHGLGECNSSASSNPSPVTF--------SSSVVDHPL 2545
            :..|.:         |.|.              |..:|::..|:...|        :.|:::.| 
Mouse   243 NHPGDS---------PLPT--------------EARASSTGKPTHEWFLQRDSEGDTPSLINWP- 283

  Fly  2546 AGAGRCK-RQGILKKRSSLDESRYYSRSHSPDERSILIKSARRNSLEEAGTGLSPAQAHGI---L 2606
               .|.| |:.::|:.|        :|| ||:..|..:...|:          .||.||.:   .
Mouse   284 ---SRVKVREKLVKEES--------ARS-SPELTSESLTQRRQ----------QPAPAHFLPIQS 326

  Fly  2607 KQSSYDSSKSDGCPSATESQP--------HSILKKKDSLSTPSDGGCHKHV-----SISQAVTLA 2658
            :.|::|...|....|...||.        |:|  |..::.||........|     .:.::.||.
Mouse   327 ESSTFDRVTSKAVSSLQPSQSGVLPTDPVHAI--KLVTMDTPESTSEFSWVGSATPKVIKSTTLK 389

  Fly  2659 AAELAAHDGITFDDGEEHEIRPIL-----KQESTSSEEAV-RPPKPIL----------KKKSFGE 2707
            ..|..:.|.            |:|     |.|...|.|.: |.||.:|          .|...|.
Mouse   390 ILEGGSRDA------------PVLHICESKAEDWLSPEPLERSPKSLLTSEDDRLVRGHKDPSGN 442

  Fly  2708 AD---------------EHEIRPILKSSRKSSREEFDLSGLENEVND--SLSSILKTDSPSKRRS 2755
            .|               |.:::.:  .::::.|.|..|......|:.  :|:|..|..||.||:.
Mouse   443 KDLDKAIICSIDVESERERQVQHL--PTQRTGRSEMLLYVQSGPVSQDATLTSHTKEASPKKRKV 505

  Fly  2756 LGSALHDLEESTTSPSML-------KRRTRSLERQDVQ---PGMDLAAALDAIATSQATPSTPVD 2810
            |..:|.|.    |.|..|       :..::.||.|..:   ||.: |:.||              
Mouse   506 LARSLSDY----TGPPQLQVPRHKDEAPSQELELQSSRAEGPGAE-ASVLD-------------- 551

  Fly  2811 FVTTPTSISVAE---------RIKRMEMLSTPTSRAAGGANSSWESPLQASSAEHGAPTTPRVLK 2866
                 |.:|||:         |..:...|.:...|:|.|.....|       .|.|:....|.|.
Mouse   552 -----TRVSVAQLRNIFMESTRASKKPELQSRVERSAEGIGLPME-------RERGSRKPRRYLS 604

  Fly  2867 PSVLRRDLQRERYKTQPVTNEEMS---------------------------------FFKANSAP 2898
            |...|:  ..||::|||:|:.|..                                 .|:.....
Mouse   605 PGESRK--TSERFRTQPITSAERKESDRYPSGSEIPVVEDEEKVDERAKLSVAAKRLLFREMEKS 667

  Fly  2899 FDISATSAFKPTKP--------LDIRLTHAPHAPLISPITGQPL---SHVPAPLLLSSSTN--SG 2950
            ||       :.|.|        ::.||..........|||.:.:   :..|.|...|..|:  :.
Mouse   668 FD-------EHTVPKRHSRNAAVEQRLRRLQDRSHTQPITTEEVVIAATEPIPASCSGVTHPVTA 725

  Fly  2951 AGSSFRLARSSTQPLQSPRVVHLAGQATGGSALARQNSVNDSINLSEQLTLSIGTDSEHIFEMSA 3015
            ...|..:||||.||.:.....|       ..|||| :..|:....:|.     |           
Mouse   726 RLPSPTVARSSVQPARLQASAH-------QKALAR-DQANEGRESAEP-----G----------- 766

  Fly  3016 LEEDSAIQSLSDETAASASANSTSTTTATTMTPPSGLTRSNSVRARANMFQ-QLQEQSRNQRAT- 3078
             |.||:..||:::.|           ....::.|  ::::.|.|.|.::.| ::..:.:.|..| 
Mouse   767 -EPDSSTLSLAEKLA-----------LFNKLSQP--VSKAISTRNRIDVRQRRMNARYQTQPVTL 817

  Fly  3079 GTTNSRQ-------SPPA-SSAEVSSSAADNSMHSDER--STPNATIDAEFGKPSTE----PLKS 3129
            |.....|       ||.. :|..:.:||...:...|.|  |..|.|...::..|..|    |::|
Mouse   818 GEVEQVQSGKLISFSPTVNTSVSIMASAVAPTYAGDLRKLSVDNNTSATDYKSPPAENSDSPVRS 882

  Fly  3130 ILK--TGMPVM--GMGRGLMPVDLNAELKNRLKRSTHATVSNLRKSATSADATRAASDEVDNPQR 3190
            |||  ...|::  ...:|:.......|.||.|      ||:    :..|...||.|.:|.:.|..
Mouse   883 ILKPQAWRPLVEHSGSKGMPGESGKTESKNAL------TVA----AEDSGVQTRGAFEEEEEPSY 937

  Fly  3191 NLAQILRNVSKENSTPKHDDAVSLVRNLSTLGQPRSLARDDAAGNCASASEGESSGGREIEAIIK 3255
            .:...:|....:.. |||   |.|.|....||.|            ::|..|:.         :|
Mouse   938 PILGRVREGDGQKE-PKH---VVLRRGSLELGNP------------SAAHLGDE---------LK 977

  Fly  3256 NSAVARRRRQQQQQSQQQNQPDGNLVAKSKSHSGISAPIGLGPQLPPLPLGGGFVKLRHVAKE-- 3318
            ..:.|:...|:            ||..|.|..|..:..:..             |..:...||  
Mouse   978 EVSTAKSSLQE------------NLDLKDKQASEENTDVET-------------VMRKFSLKEFG 1017

  Fly  3319 EDTSSSSNTSSAKESPDKKD----LRQEQAEASGDSSHPTALPQFLQGVQRSSTEVMGPDQRSLV 3379
            |.||..:..::.|.|.....    .:||.:|...:.........|..|      ||..|...|.:
Mouse  1018 ETTSEQTEVAARKASVQMATPGAWKQQESSEQLAEKLFKNPCAMFASG------EVKVPVGDSFL 1076

  Fly  3380 --ISKTGSIAERLAALHKSGEDDWKKRISKRDE----VDDVHRENFVNESLSLAH--SLSDKPLP 3436
              .|||.||.||||.|.||||:|||.|:.::.|    ...:|.:. |.:||....  .|:|....
Mouse  1077 DSPSKTMSIKERLALLKKSGEEDWKNRLIRKQEYGKATGGLHTQE-VEQSLKKKEEGGLTDDNAI 1140

  Fly  3437 PSPL--IPTSLEGG-KVSDRLSKLKCNSENWKQ--RIEQTDAKKFTVAGRLQKKAQSPVELQFER 3496
            .:.|  :..|.|.. .:.:|...:....|.||.  |....|:.:||||||:.||           
Mouse  1141 SNVLWRVTESRESQMTIEERKHLITVREEAWKTKGRGAANDSTQFTVAGRMVKK----------- 1194

  Fly  3497 SANDAAKKCPMLEVRSANQPQLGLAKSPSM------MVTSSTSTNSTSKSALRSLSVNPEEEGPT 3555
                                  |||...|:      :.:.|..|...|| .|..:...|:.:   
Mouse  1195 ----------------------GLASPTSITPISSPLCSKSRGTTPVSK-PLEDIEARPDMQ--- 1233

  Fly  3556 SLSRSNSSSSESDGERKSPQNAKQNKELANNKSAAAPTNV----GARI-QVPRLDDKETFENFFS 3615
                     .|||.:....:...:.   .|||.|.....|    |..: :|.:|||.|||..|:.
Mouse  1234 ---------LESDLKLDRLETFLRR---LNNKVAGIQETVLTVTGKSVKEVMKLDDDETFAKFYR 1286

  Fly  3616 SK----PKKEENVQLEISA-FDDIKPTERLVS-----KRHVQGPKGR-RAARNPLKSLAAREDIS 3669
            |.    |:....::.:... ||...|  :|.|     ||.|: ||.| :|::||||.||||:|:.
Mouse  1287 SVDHSIPRSPVELEEDFDVIFDPYAP--KLTSSVAEHKRQVR-PKRRVQASKNPLKLLAARDDLL 1348

  Fly  3670 SEYTEMRSGIAERELRRLKLESYGHNANLAAEAIAGLASVEDFKSVALRSSSIPLQ---QMWLPH 3731
            .||||.|..:|..|.:|:|:|....|:|.:...:|||||.|:|.::.|||.::..|   ...:|:
Mouse  1349 QEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASRENFSNINLRSVNLMEQNSNNSAMPY 1413

  Fly  3732 KPVMLLHVKGRTHVQTRLVEPVHTSLNRGDCFILVAGSQLFRYVGSFANVIEISRSKKICAAIVE 3796
            |.:|||.:|||.|||||||||..:|||.||||:|::....|.:||.|:||||.:::.::...|..
Mouse  1414 KKLMLLQIKGRRHVQTRLVEPRASSLNSGDCFLLLSPQYCFLWVGEFSNVIEKAKASELATLIQT 1478

  Fly  3797 NKDLGCTATQEVILTDGKYLKERQWRQFWQLLGKKEDDQSDIAECGHADEDDVFESSLIETNKIY 3861
            .::|||.||....:.:|........:.||:|||.:...||    .|...||:::|:::||||.:|
Mouse  1479 KRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQS----AGDPKEDELYETAIIETNCVY 1539

  Fly  3862 EYQDEALIPLEKFWGCIPKVDMLDTRKVLVFDFGSELYVWNGKNAPSDAKRAAMRLAQEHFGAEN 3926
            ...|:.|:|.:.:||.|||..:|.:::|||||||||:|||:||......::.|.:||:..:  ..
Mouse  1540 RLTDDKLVPDDDYWGKIPKCSLLQSKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLW--NG 1602

  Fly  3927 SADYADCYLNPLNYVAIVGRRENTKYAKRCAQRPEWCVLGKITQNMETVLFKEKFSDWPEIERED 3991
            :.||.:|.:|||:     ....|....::...||:|.:.|::|::.||:||||||.||.|::| .
Mouse  1603 TFDYENCDINPLD-----PGECNPLIPRKGQGRPDWAIFGRVTEHNETILFKEKFLDWTELKR-P 1661

  Fly  3992 LEKDYLSNGVHMVRALNGTALHKGE-------PYQEPNLV----------LEQANLGRGNFYYDT 4039
            .||:            :|..:.:.:       ||....:|          |:..|:|||....:.
Mouse  1662 TEKN------------SGEVVQQKDDPRADVKPYDVTRMVATPQITAGTILDGVNVGRGYGLVEG 1714

  Fly  4040 DTMRHFDVITKSTDKWQIHEFNFDAANNRDDYGHFYSAESYIVRWIYQISVTVRELSGKVSNRST 4104
            |..|.|::.|.|.|.|.|.||::... .|...|.|:..::|:|:|.|..|..|............
Mouse  1715 DDRRQFEIATVSVDVWHILEFDYSRL-PRQSIGQFHEGDAYVVKWKYMASTAVGSRQKGEHLVRV 1778

  Fly  4105 VGRDRCVYFTWQGQDSSANEKGAAALLTVELDKEKGAQMRVSQGDECTAFVRLFR-QMWQHRGRK 4168
            .|:::||||.|||:.|:.:|||.:||:|||||:|:|||::|.||.|...|::.|: .|..|.||:
Mouse  1779 AGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRR 1843

  Fly  4169 EQCLER-HSEWRLYQLQGNVSEETIIKEVVCQSSHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTR 4232
            |:..|. .||||||.::|.|..|..:.||.|..|.||||:||::::.::..:.:|||.|:..||:
Mouse  1844 EEEEENVQSEWRLYCVRGEVPMEGNLLEVACHCSSLRSRTSMVVLNINKALIYLWHGCKAQGHTK 1908

  Fly  4233 NVAVGVAQDLIKTVPKD--LFSAETANLTEVEEGSDDDQCKKALGLKDERNEYGSLLKSTKSFDY 4295
            .|....|..:.:..|.:  |.|:....:.|.:|||:......|||.:| |..|..:|:...||::
Mouse  1909 EVGRTAANKIKEECPLEAGLHSSSNVTIHECDEGSEPLGFWDALGRRD-RKAYDCMLQDPGSFNF 1972

  Fly  4296 QIRIFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQLYNARQPTIFLLDDGDELWLWMGWWPL 4360
            ..|:|..||:.|.|.|.|...|.:.....|..||.|..||:|.||.:||:|:..|::||.||||.
Mouse  1973 APRLFILSSSSGDFSATEFVYPAQAPSAVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPT 2037

  Fly  4361 EDVKINTDERSSPTNENRAGVNRWISERRAALETAVDYWRAKHGENENEPFHGIKGQVVWAGLEP 4425
            |: ||....|.           ||.|:|::|:||.:.|.|   |:|...|  ..|..::.|||||
Mouse  2038 EN-KITGSARI-----------RWASDRKSAMETVLQYCR---GKNLKRP--PPKSYLIHAGLEP 2085

  Fly  4426 LAFKALFPDWTERPDVREINEEDGRTDASIS-IATMLAQMTQTEYPLEVLKARPLPEGVEPTRLE 4489
            |.|..:||.|..|.|:.||.|.|......|: :..:||::.:|.|||..|.||||||||:|.:||
Mouse  2086 LTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLE 2150

  Fly  4490 VYLNAEDFQAALGCSRAEFEQLPIWKQTKLKKERGLF 4526
            :||..|||:.||..||.||..||.|||..|||.:|||
Mouse  2151 IYLTDEDFEFALDMSRDEFNALPTWKQVNLKKSKGLF 2187

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SvilNP_001286919.1 gelsolin_S2_like 3733..3825 CDD:200445 38/91 (42%)
gelsolin_like 3859..3965 CDD:200436 37/105 (35%)
ADF_gelsolin <4069..4158 CDD:301701 36/88 (41%)
gelsolin_S5_like 4176..4279 CDD:200444 37/104 (36%)
ADF_gelsolin 4328..4435 CDD:301701 44/106 (42%)
VHP 4492..4526 CDD:280388 19/33 (58%)
SvilXP_006525852.1 gelsolin_S2_like 1415..1511 CDD:200445 30/111 (27%)
gelsolin_like 1536..1636 CDD:200436 46/102 (45%)
gelsolin_S4_like 1719..1832 CDD:200449 39/112 (35%)
gelsolin_S5_like 1852..1957 CDD:200444 28/121 (23%)
ADF_gelsolin 1974..2096 CDD:417759 54/123 (44%)
VHP 2152..2187 CDD:128458 11/34 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 48 1.000 Domainoid score I11896
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1376537at2759
OrthoFinder 1 1.000 - - FOG0004673
OrthoInspector 1 1.000 - - oto92484
orthoMCL 1 0.900 - - OOG6_105657
Panther 1 1.100 - - LDO PTHR11977
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3618
SonicParanoid 1 1.000 - - X2758
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.950

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