DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Svil and Scin

DIOPT Version :9

Sequence 1:NP_001286919.1 Gene:Svil / 38306 FlyBaseID:FBgn0266696 Length:4526 Species:Drosophila melanogaster
Sequence 2:NP_001139668.1 Gene:Scin / 20259 MGIID:1306794 Length:715 Species:Mus musculus


Alignment Length:723 Identity:164/723 - (22%)
Similarity:302/723 - (41%) Gaps:174/723 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  3736 LLHVKGRTHVQTRLVEPVHTSLNRGDCFILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDL 3800
            |||||||..|:...|.....|.|:|||||:..|::::::.||..|..|..::.::...|.:|:..
Mouse   139 LLHVKGRRVVRATEVPLSWESFNKGDCFIIDLGTEIYQWCGSSCNKYERLKASQVAIGIRDNERK 203

  Fly  3801 GCTATQEVILTDGKYLKERQWRQFWQLLGKKEDDQSDIAECGHADEDDVFESSLIETNKIYEYQD 3865
            |  .:|.:::.:|....|     ..::||:|.:     ...|..|:|.|.:.|..:..|:|...|
Mouse   204 G--RSQLIVVEEGSEPSE-----LMKVLGRKPE-----LPDGDNDDDVVADISNRKMAKLYMVSD 256

  Fly  3866 EA------LIPLEKFWGCIPKVDMLDTRKVLVFDFGS--ELYVWNGKNAPSDAKRAAMRLAQEHF 3922
            .:      |:..|..:    .:.||.:.:..:.|.|:  :::||.||||....::.||:.|:|  
Mouse   257 ASGSMKVTLVAEENPF----SMGMLLSEECFILDHGAAKQIFVWKGKNANPQERKTAMKTAEE-- 315

  Fly  3923 GAENSADYADCYLNPLNYVAIVGRRENTKYAKRCAQRPEWCVLGKITQNMETVLFKEKFSDWPEI 3987
                       :|..:.|      ..||:             :..:.:..||.:||:.|.||.:.
Mouse   316 -----------FLQKMKY------STNTQ-------------IQVLPEGGETPIFKQFFKDWKDK 350

  Fly  3988 ERED-LEKDYLSNGVHMVRAL--NGTALHKGEPYQEPNLVLEQANLGRGNFYYDTDTMRHFDVIT 4049
            ::.| ..|.|::..|..::.:  :.:.||     ..|.:..:...:..|               :
Mouse   351 DQSDGFGKVYITEKVAQIKQIPFDASKLH-----SSPQMAAQHNMVDDG---------------S 395

  Fly  4050 KSTDKWQIH---EFNFDAANNRDDYGHFYSAESYIVRWIYQISVTVRELSGKVSNRSTVGRDRCV 4111
            ...:.|::.   ....|.::    ||.||..:.||:.:.|.                   |.:.:
Mouse   396 GGVEIWRVENSGRVQIDPSS----YGEFYGGDCYIILYTYP-------------------RGQII 437

  Fly  4112 YFTWQGQDSSANEKGAAALLTVELDKEKG---AQMRVSQGDECTAFVRLFRQ----MWQHRGRKE 4169
            | ||||.:::.:|...:|.|||:||:..|   .|:|||||.|....:.||:.    ::::...|:
Mouse   438 Y-TWQGANATRDELTMSAFLTVQLDRSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSKK 501

  Fly  4170 QCLERHSEWRLYQLQGNVSEETIIKEVVCQSSHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTRNV 4234
            :........||:|::.|::..|.|.||...::.|.|..:.:| ...:.|..:|.|..::......
Mouse   502 EGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDTFVL-KLPRNNGFIWIGKGASQEEEKG 565

  Fly  4235 AVGVAQDLIKTVPKDLFSAETANLTEVEEGSDDDQCKKALGLKDERNEY-GSLLKSTKSFDYQIR 4298
            |..|| |::|           ...:.::||.:.::...:||   .|.:| .|.|..|::.|:..|
Mouse   566 AEYVA-DVLK-----------CKASRIQEGKEPEEFWNSLG---GRGDYQTSPLLETRAEDHPPR 615

  Fly  4299 IFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQLYNARQPTIFLLDDGDELWLWMGWWPLEDV 4363
            ::..|:..|.|...|:           |..|:|..|   .:..:.|||..:::::|:|       
Mouse   616 LYGCSNKTGRFIIEEV-----------PGEFTQDDL---AEDDVMLLDAWEQIFIWIG------- 659

  Fly  4364 KINTDERSSPTNENRAGVNRWISERRAALETAVDYWRA-KHGENENEPFHGIKGQVVWAGLEPLA 4427
                    ...||         .|::.::::|..|... ..|.::..|...||     .|.||..
Mouse   660 --------KDANE---------VEKKESVKSAKMYLETDPSGRDKRTPIVIIK-----QGHEPPT 702

  Fly  4428 FKALFPDW 4435
            |...|..|
Mouse   703 FTGWFLGW 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SvilNP_001286919.1 gelsolin_S2_like 3733..3825 CDD:200445 27/88 (31%)
gelsolin_like 3859..3965 CDD:200436 23/113 (20%)
ADF_gelsolin <4069..4158 CDD:301701 28/91 (31%)
gelsolin_S5_like 4176..4279 CDD:200444 23/102 (23%)
ADF_gelsolin 4328..4435 CDD:301701 22/107 (21%)
VHP 4492..4526 CDD:280388
ScinNP_001139668.1 Actin-severing. /evidence=ECO:0000255 1..363 68/271 (25%)
gelsolin_S1_like 10..121 CDD:200446
Polyphosphoinositide binding. /evidence=ECO:0000250 112..119
gelsolin_S2_like 136..225 CDD:200445 27/92 (29%)
Polyphosphoinositide binding. /evidence=ECO:0000250 138..146 6/6 (100%)
gelsolin_S3_like 246..346 CDD:200448 28/135 (21%)
Ca(2+)-dependent actin binding 364..715 96/450 (21%)
gelsolin_S4_like 390..486 CDD:200449 31/134 (23%)
gelsolin_S5_like 508..598 CDD:200444 24/105 (23%)
gelsolin_S6_like 613..711 CDD:200447 29/141 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1376537at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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