DRSC/TRiP Functional Genomics Resources

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Protein Alignment Svil and fli-1

DIOPT Version :9

Sequence 1:NP_001286919.1 Gene:Svil / 38306 FlyBaseID:FBgn0266696 Length:4526 Species:Drosophila melanogaster
Sequence 2:NP_498913.2 Gene:fli-1 / 176215 WormBaseID:WBGene00001443 Length:1257 Species:Caenorhabditis elegans


Alignment Length:1602 Identity:336/1602 - (20%)
Similarity:547/1602 - (34%) Gaps:547/1602 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  3006 DSEHIFEMSALE-EDSAIQSLSDETAASASANSTSTTTATTMT---PPSGLTRSNSVRARAN--- 3063
            |.|.:.:|:.|: .||.::.:.||.:..|:...........::   ..|.|.|..||..|.|   
 Worm    27 DVEQMTQMTWLKLNDSKLEQVPDELSRCANLEHLQMAHNQLISVHGELSDLPRLRSVIVRDNNLK 91

  Fly  3064 -------MFQQ----LQEQSRNQRATGTTNSRQSPPASSAEVSSSAADNSMHSDERSTPNAT--- 3114
                   :|:.    :.:.||||.....||...:        ..|...|..:::..:.||:.   
 Worm    92 TAGIPTDIFRMKDLTIIDLSRNQLREVPTNLEYA--------KGSIVLNLSYNNIETIPNSVCAN 148

  Fly  3115 -IDAEFGKPSTEPLKSILKTGMPVMGMGRGLM----PVDLNAELKNRLKRSTHATVSNLRKSATS 3174
             ||..|...|...| .:|...:..:.|.:.|.    |:: :.:|| :|...|..:|.::..:..:
 Worm   149 LIDLLFLDLSNNKL-DMLPPQIRRLSMLQSLKLSNNPLN-HFQLK-QLPSMTSLSVLHMSNTNRT 210

  Fly  3175 ADATRAASDEVDNPQRNLAQILRNVS-KENSTPKHDDAVSLVRNLSTLGQPRSLARDDAAGNCAS 3238
            .|......|::.|        ||:|. .||:.|...:|:..:|||..|                 
 Worm   211 LDNIPPTLDDMHN--------LRDVDFSENNLPIVPEALFKLRNLRKL----------------- 250

  Fly  3239 ASEGESSGGREIEAIIKNSAVARRRRQQQQQSQQQNQPDG---NLVAKSKSHSGISAPIGLGPQL 3300
                 :..|.:||.:                    |..:|   ||...:.||:          ||
 Worm   251 -----NLSGNKIEKL--------------------NMTEGEWENLETLNMSHN----------QL 280

  Fly  3301 PPLPLGGGFVKLRHVAKEEDTSSSSNTSSAKESP----------------DKKDLRQE------- 3342
            ..||  ...|||..:.|   ..:::|..:.:..|                :|.:|..|       
 Worm   281 TVLP--DCVVKLTRLTK---LYAANNQLTFEGIPSGIGKLIQLTVLHLSYNKLELVPEGISRCVK 340

  Fly  3343 QAEASGDSSHPTALPQFLQGVQRSSTEVMGPDQRSLVISKTGSIAERLAALHKSGEDDWKKRISK 3407
            ..:...|.:....||   :|:.      :.||.:.|.:.:.    |.|....|  .:|.:|::: 
 Worm   341 LQKLKLDHNRLITLP---EGIH------LLPDLKVLDLHEN----ENLVMPPK--PNDARKKLA- 389

  Fly  3408 RDEVDDVHRENFVNESLSLAH--SLSDKPLPPSPLIPTSLEGGKVSDRLSKLKCNSENWKQRIEQ 3470
                       |.|...||.|  .::.:...||..|.:...||...|.|::.|   |..::|.:|
 Worm   390 -----------FYNIDFSLEHQRKIAGQMTSPSSSISSVHSGGARQDALARRK---EFIRRRKQQ 440

  Fly  3471 TDAKKFTVAGRLQKKAQSPVELQFERSANDAAKKCPMLEVRSANQPQLGLAKSPSMMVTSSTSTN 3535
            .|          |:.|...::                           |::|...:         
 Worm   441 AD----------QQSADKVIQ---------------------------GMSKIAGV--------- 459

  Fly  3536 STSKSALRSLSVNPEEEGPTSLSRSNSSSSESDGERKSPQNAKQNKELANNKSAAAPTNVGARIQ 3600
                              ..:|:.......|...|.||..|.|:|.|  .|:         ..|.
 Worm   460 ------------------GAALTEKQQEEEERQLEAKSAVNWKKNIE--KNR---------RHID 495

  Fly  3601 VPRLDDKET----------FENFFSS-------------------KPKKEENVQLEISAF----D 3632
            ...:.|::.          .|||:.|                   |..:|.:.||..:.|    :
 Worm   496 YSDIFDEDVGSDEGMWVWEIENFYPSIMDEAFHGQFYDADAYLVLKTTREASGQLRHAIFYWLGE 560

  Fly  3633 DIKPTERLVSKRHVQGPKGRRAARNPLKSL--AAREDISSEYTEMRSGIAERELRRLKLESYGHN 3695
            .....:.:.|..|..|      .||.|.:.  ..||:::.|..|..:...| |:..::       
 Worm   561 HASLDKGMCSAVHAVG------LRNHLNATCRTQREEMNDETEEFLTLFGE-EIVYIE------- 611

  Fly  3696 ANLAAEAIAGLASVEDFKSVALRSSSIPLQQMWLPHKPVMLLH-----VKGRTHVQTRLVEPVHT 3755
               ....|:|..:.|                     ||..|..     |.| |.|:   :|||..
 Worm   612 ---GGRTISGFYTTE---------------------KPAHLTRLYRAGVNG-TAVE---MEPVPL 648

  Fly  3756 SLNRGD---CFILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVILTDGKYLK 3817
            |:...|   ||:|.||..::.:.| :.:.|.:|...::.|..:..:|           ..||...
 Worm   649 SVESLDPRFCFLLDAGETIWIWSG-YKSRITVSNKARLFAERLNKRD-----------RKGKSEI 701

  Fly  3818 E--RQWR---QFWQ-LLGKKEDDQSDIAECGHADEDDVFESSLIETNKIYE------YQDEALIP 3870
            |  ||.|   :||| |.|..:..|..|.|       .|.|..:.|..|:|:      :.:...:.
 Worm   702 ETCRQARCPPEFWQALTGNPDKPQGAIVE-------HVPEGFVAERKKLYKVNIGMGFLELPQVE 759

  Fly  3871 LEKFWGCIPKVDMLDTRKVLVFDFGSELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYL 3935
            |.|   .|.|.|||.::.|.|.|..|::::|.||.|....|.|..:|..|.....:..|||..| 
 Worm   760 LPK---GIAKQDMLGSKGVFVLDSNSDIFLWIGKKANRLLKMAGQKLVVELHQMIDRPDYAQVY- 820

  Fly  3936 NPLNYVAIVGRRENTKYAKRCAQRPEWCVLGKITQNMETVLFKEKFSDWPEIERED--------- 3991
                       ||                    |:..|:::|:.||:.|.||...|         
 Worm   821 -----------RE--------------------TEGEESMMFRSKFAGWDEIVPVDYTRTSDSVQ 854

  Fly  3992 --------LEKDYLSNGVHMVRALNGTALHKGEP---YQEPNLVLEQANLGRGNFYYDTDTMRHF 4045
                    ::||      :|:||.......:.:|   |:|...::|..|       ||.:.|..|
 Worm   855 RVPDLKVIVKKD------NMMRADLAALFLERQPSMSYEESEELMEDCN-------YDLELMESF 906

  Fly  4046 DVITKSTDKWQIHEFNFDAANNRDDYGHFYSAESYIVRWIYQISVTVRELSGKVSNRSTVGRD-- 4108
            .:..|...|....||           |.||:.:.|:....|.:          :......|.|  
 Worm   907 VLEGKKFVKLPQKEF-----------GIFYTMDCYVFLCRYAV----------MPEEDEEGEDEH 950

  Fly  4109 ----------RCVYFTWQGQDSS------------ANEKGAAALLTVELDKEKGAQMRVSQGDEC 4151
                      :||.:.|||:|:|            .|.:        |:.|:|...:|:.|..|.
 Worm   951 DEDDKPEMDFKCVVYFWQGRDASNMGWLNFTFQLQPNFE--------EIFKDKLEVVRMYQQQEN 1007

  Fly  4152 TAFVRLF-RQMWQHRGRKEQCLERHSEW-RLYQLQGN---VSEETIIKEVVCQSSHLRSR-SSML 4210
            ..|:..| |:....|||:........:| .|:|::.|   |...||  :|.||::.|.|. ..||
 Worm  1008 HKFLSHFKRKFLIKRGRRGLTKNLGGKWPELFQMRANGSSVCNRTI--QVDCQANQLCSAFCHML 1070

  Fly  4211 LI-------HGSQGNVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKDLFSAETANLTEVEEGSDDD 4268
            .|       .|.:|.|.||.|..|.|.....|..||.||:.....:.|     .:.||:||.:::
 Worm  1071 RIPFKEIEEDGHRGVVYVWMGKDSDPREHEFARQVASDLVVRDDDNDF-----RIVEVQEGEENE 1130

  Fly  4269 QCKKALGLKDERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQ 4333
            :..|.||.|.:.....|.:|.|       |:|..::.:|.|...|.:... |||           
 Worm  1131 EFWKVLGGKKKYETDSSFVKHT-------RLFRCTNEKGYFAISEKTVDF-CQD----------- 1176

  Fly  4334 LYNARQPTIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGVNRWISERRAALETAVDY 4398
              :.....|.:||:||.::||:|            .|||..            |.:.:.:.|..|
 Worm  1177 --DLDDDDIMILDNGDAVFLWIG------------ARSSDI------------EAKLSYQAAQVY 1215

  Fly  4399 ---WRAKHGENENEPFHGIKGQVVWAGLEPLAFKALFPDWTE 4437
               .|.|..|...:....::|:      |...|:..|..|::
 Worm  1216 HASMRMKANEKPRKFMLAVRGR------ESCRFRKCFHAWSK 1251

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SvilNP_001286919.1 gelsolin_S2_like 3733..3825 CDD:200445 27/104 (26%)
gelsolin_like 3859..3965 CDD:200436 27/111 (24%)
ADF_gelsolin <4069..4158 CDD:301701 22/112 (20%)
gelsolin_S5_like 4176..4279 CDD:200444 37/114 (32%)
ADF_gelsolin 4328..4435 CDD:301701 21/109 (19%)
VHP 4492..4526 CDD:280388
fli-1NP_498913.2 leucine-rich repeat 9..33 CDD:275380 2/5 (40%)
LRR_RI <13..162 CDD:238064 31/142 (22%)
LRR_8 32..90 CDD:290566 14/57 (25%)
leucine-rich repeat 35..56 CDD:275380 5/20 (25%)
leucine-rich repeat 57..79 CDD:275380 2/21 (10%)
LRR_8 78..138 CDD:290566 14/67 (21%)
leucine-rich repeat 80..104 CDD:275380 5/23 (22%)
leucine-rich repeat 105..128 CDD:275380 6/30 (20%)
LRR_RI 129..373 CDD:238064 60/324 (19%)
leucine-rich repeat 129..151 CDD:275380 3/21 (14%)
LRR_8 130..185 CDD:290566 11/55 (20%)
leucine-rich repeat 152..174 CDD:275380 4/22 (18%)
leucine-rich repeat 175..198 CDD:275380 5/24 (21%)
LRR_8 197..257 CDD:290566 17/89 (19%)
leucine-rich repeat 199..223 CDD:275380 3/23 (13%)
leucine-rich repeat 224..246 CDD:275380 7/21 (33%)
LRR_8 245..303 CDD:290566 22/114 (19%)
leucine-rich repeat 247..269 CDD:275380 7/63 (11%)
leucine-rich repeat 270..292 CDD:275380 10/33 (30%)
leucine-rich repeat 293..317 CDD:275380 3/26 (12%)
LRR_8 317..372 CDD:290566 10/63 (16%)
leucine-rich repeat 318..338 CDD:275380 3/19 (16%)
leucine-rich repeat 341..363 CDD:275378 4/30 (13%)
gelsolin_S1_like 502..613 CDD:200446 21/127 (17%)
gelsolin_like 629..717 CDD:200436 28/103 (27%)
gelsolin_S3_like 738..837 CDD:200448 33/133 (25%)
gelsolin_like 928..1014 CDD:200436 19/103 (18%)
gelsolin_S5_like 1034..1141 CDD:200444 37/113 (33%)
ADF_gelsolin 1151..1250 CDD:301701 30/149 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1376537at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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