DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Svil and viln-1

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	NP_491442.1	Gene:	viln-1 / 172089	WormBaseID:	WBGene00015691	Length:	918	Species:	Caenorhabditis elegans

Alignment Length:	1163	Identity:	273/1163 - (23%)
Similarity:	449/1163 - (38%)	Gaps:	305/1163 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  3420 VNESLSLAHSLSDKP--LPPSPLIPTSLEGGKVSDRLSKLKCNSENWKQRIEQTDAKKFTVAGRL 3482
            :.:||...:|..:|.  :..:|:...||:     |||:.|..::|.||.|.|:..|
Worm     5 LQKSLIQQNSTFEKKNNVEVAPIAKISLK-----DRLASLNNSAEQWKSRPERQPA--------- 55

  Fly  3483 QKKAQSPVELQFERSANDAAKKCPMLEVRSANQPQLGLAKSPSMMVTSSTSTNSTSKSALRSLSV 3547
                     :|..|::.:..:..|:.:                                 |:..:
Worm    56 ---------VQQRRTSANVLQDLPIFQ---------------------------------RAQQL 78

  Fly  3548 NPEEEGPTSLSRSNSSSSESDGERKSPQNAKQNKELANNKSAAAPTNVGARIQVPRLDDKETFEN 3612
            :.:::.|.|.....        |:.....:...|...:|     ||..||...:|::.
Worm    79 HQQQQRPQSFPVVQ--------EKPCDITSGLKKFFGSN-----PTTSGASSSLPKIS------- 123

  Fly  3613 FFSSKPKKEENVQLEISAFDDI-------KPTERLVSKRHVQGPKGRRAARNPLKSLAAREDISS 3670
                          ||:|.:||       |.|..|.:....:.|..:::.::.......|.| :.
Worm   124 --------------EITASNDIDLDAISSKATPVLKTVTRPRAPNRKKSDKSSTFDERIRLD-AV 173

  Fly  3671 EYTEMRSGIAERELRRLKLESYGHNANLAAEAIAGLASVEDFKSVALRSSSIPLQQMWLPHKPVM 3735
            :..|....:.|.|..:|:.:.         :|||.:...:.......:.|         |:..||
Worm   174 KIDEEAFAVVEEEPEKLETQE---------QAIAAIQGAKQLLKSPTKVS---------PYPDVM 220

  Fly  3736 LLHVKGRTHVQTRLVEPVHTSLNRGDCFILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDL 3800
            |:.|:|..:|..|||.|..:|::...||::|....|.:|.|.::|::|.:::.::|..|:...||
Worm   221 LIQVRGSKNVDVRLVAPAMSSVHEVACFVVVHQKHLMKYEGLYSNILEKTKASQLCIEILGKSDL 285

  Fly  3801 GCTATQEVILTDGKYLKERQWRQFWQLLGKKEDDQSDIAECGHADEDDVFESSLIETNKIY---- 3861
            .|||...|.:|..    .|..........:..:..|:......|...:.||:::.:.|.:.
Worm   286 NCTAESIVTVTGA----SRSTLSKLLFCSENSESSSENNNYHQASSVEPFETTVAKLNLVLRIAG 346

  Fly  3862 EYQDEALIPLEKFWGCIPKVDMLDTRKVLVFDFGSELYVWNGKNAPSDAKRAAMRLAQEHFGAEN 3926
            :...|.....|:.     ..:::...:||:||||||:|||.|:                 :..:.
Worm   347 DNTAETCSRRERL-----SYEIMKPSEVLIFDFGSEIYVWTGR-----------------YSNKV 389

  Fly  3927 SADYADCYLNPLNYVAIVGRRENTKYAKRCAQ------RPEWCVLGKITQNMETVLFKEKFSDWP 3985
            |:.||..|...|....:    :|.|:....|:      ||||.:..||.|.:...|||.||||||
Worm   390 SSAYAQEYAKQLMKKPV----KNGKFILGDAESIDQDGRPEWTLSRKIHQGVLDTLFKAKFSDWP 450

  Fly  3986 E-------------IEREDLE-KDY----LSNGVHMVRALNGTALHKGEPYQEPNLVLEQANLGR 4032
            |             |.:::.| |.|    :.|....|..|....|.:.|  .:|.||||...:.|
Worm   451 ETREVLTTCKPRALISKKNPEVKTYEDVKVVNQDDEVADLVERMLQEQE--LDPILVLEDQEIDR 513

  Fly  4033 GNFYYDTDTMRHFDVITKSTDKW--------QIHEFNFDAANNRDDYGHFYSAESYIVRWIYQIS 4089
                      :..|||::....|        .|.||.          .||.|...|::||.|:|.
Worm   514 ----------KIHDVISEDRSLWVLRGEVLQSIEEFT----------EHFDSRRCYVLRWKYRIQ 558

  Fly  4090 VT-VREL-SGKVSNRSTVGRDRCVYFTWQGQDSSANEKGAAALLTVELDKEKGAQMRVSQGDECT 4152
            .: ||.: :||...|.| ||.|..::.|.|:.::..:.|..||...|:|::...::|::.|:|..
Worm   559 KSGVRRIKTGKEEERET-GRSRIAFWYWLGEHTTPKQHGLCALRIKEIDRDNSPRIRIADGNEPA 622

  Fly  4153 AFVRLFRQMWQHRGRKEQCLERHSEWRLYQLQGNVSEETIIKEVVCQSSHLRSRSSMLLIHGSQG 4217
            .|:.||    ..:......:......|.|.:.|..|.||.::|:...:|.|||.::.:.:   :.
Worm   623 LFLALF----DGKFMVSSDISEMKPLRRYVVIGANSRETSLREIDDLNSPLRSHAAYIEV---EK 680

  Fly  4218 NVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKDLFSAE--------TANLTEVEEGSDDDQCKKAL 4274
            :::       .|.:........:|.:..|   |..||        ..|..|:|...|
Worm   681 DIL-------GPSSVVCGANCTEDQVHFV---LAHAEYMRQKAGVKGNSAEIEVEGD-------- 727

  Fly  4275 GLKDERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQLYNARQ 4339
              |..|:...|  ...|......|:|:..|.|    ...||....|     .:.|||..|    :
Worm   728 --KKSRSWVNS--NGRKRAMRVWRLFDNESEQ----VNHLSGHKNC-----AFTFSQQVL----K 775

  Fly  4340 PTIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGVNRWISERRAALETAVDYWRAKHG 4404
            .|| |:|.||.||||.     |:| |.|                      .||:.|..||:.:.|
Worm   776 ETI-LIDVGDALWLWS-----EEV-ITT----------------------FALKVAEKYWKDRSG 811

  Fly  4405 ENENEPFHGIKGQVVWAGLEPLAFKALFPDWTERPDVREINEEDGRTDASISIATMLAQMTQTEY 4469
                      ..:||:.|.||..||.||..|    ::.|: |:|..:|....::.:|.:..:| :
Worm   812 ----------PAKVVYKGAEPEQFKGLFMKW----EMFEV-EDDKPSDPPRDVSDLLKERCRT-F 860

  Fly  4470 PLEVLKAR-PLPEGVEPTRLEVYLNAEDFQAALGCSRAEFEQLPIWKQTKLKKERGLF 4526
            .||.||.| .||.|::..|||.||..:||.......|:||.....|||...:|..|||
Worm   861 SLEELKERTSLPAGMDMRRLESYLTDDDFMKVFKIERSEFYAQKTWKQNDARKRVGLF 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	29/91 (32%)
		gelsolin_like	3859..3965	CDD:200436	26/115 (23%)
		ADF_gelsolin	<4069..4158	CDD:301701	28/90 (31%)
		gelsolin_S5_like	4176..4279	CDD:200444	22/110 (20%)
		ADF_gelsolin	4328..4435	CDD:301701	33/106 (31%)
		VHP	4492..4526	CDD:280388	11/33 (33%)
viln-1	NP_491442.1	ADF_gelsolin	218..296	CDD:387665	27/77 (35%)
		gelsolin_like	<362..446	CDD:200436	30/104 (29%)
		ADF_gelsolin	545..628	CDD:387665	26/83 (31%)
		ADF_gelsolin	<779..832	CDD:387665	27/90 (30%)
		VHP	883..918	CDD:128458	12/34 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	1	1.000	-	-		FOG0004673
OrthoInspector	1	1.000	-	-		oto20344
orthoMCL	1	0.900	-	-		OOG6_105657
Panther	1	1.100	-	-	LDO	PTHR11977
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3618
SonicParanoid	1	1.000	-	-		X2758
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.950