DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Svil and Avil

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	XP_006513161.1	Gene:	Avil / 11567	MGIID:	1333798	Length:	878	Species:	Mus musculus

Alignment Length:	878	Identity:	210/878 - (23%)
Similarity:	344/878 - (39%)	Gaps:	251/878 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  3736 LLHVKGRTHVQTRLVE--------PV---------------HT-------SLNRGDCFILVAGSQ 3770
            ||||||:.::|...|.        ||               ||       |.||||.|:|..|..
Mouse   165 LLHVKGKRNIQATEVSLTRECPGCPVLPPWHLRLPRTALTAHTQVEMSWDSFNRGDVFLLDLGMV 229

  Fly  3771 LFRYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVILTDGKYLKERQWRQFWQLLGKKEDDQ 3835
            :.::.|..:|..|..:: .:.|..:.:::.|..|...||..|.:.............||::...:
Mouse   230 IIQWNGPESNSGERLKA-MLLAKDIRDRERGGRAEIGVIEGDKEAASPGLMTVLQDTLGRRSMIK 293

  Fly  3836 SDIAECGHADEDDVFESSLIETNKIYEYQDE---------ALIPLEKFWGCIPKVDMLDTRKVLV 3891
            ..::       |::.:.....:..:|...|.         |..||.:        |:|:.....:
Mouse   294 PAVS-------DEIMDQQQKSSIMLYHVSDTAGQLSVTEVATRPLVQ--------DLLNHDDCYI 343

  Fly  3892 FD-FGSELYVWNGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTKYAKR 3955
            .| .|:::|||.||.|....|:|||..|                   |:::.:.|...:|.
Mouse   344 LDQSGTKIYVWKGKGATKVEKQAAMSKA-------------------LDFIKMKGYPSSTN---- 385

  Fly  3956 CAQRPEWCVLGKITQNMETVLFKEKFSDWP-EIEREDLEKDYLSNGVHMV--RALNGTALHKGEP 4017
                     :..:....|:.:||:.|..|. :.:...|.|.:.:..:..:  ...:.:.||
Mouse   386 ---------VETVNDGAESAMFKQLFQKWSVKDQTTGLGKIFSTGKIAKIFQDKFDVSLLH---- 437

  Fly  4018 YQEPNLVLEQANL--GRGNFYYDTDTMRHFDVITKSTDKWQIH-------EFNFDAANNRDDYGH 4073
             .:|.:..::..:  |:|                 ..:.|:|.       |:.:        :|.
Mouse   438 -TKPEVAAQERMVDDGKG-----------------QVEVWRIENLELVPVEYQW--------HGF 476

  Fly  4074 FYSAESYIVRWIYQISVTVRELSGKVSNRSTVGRDRCVYFTWQGQDSSANEKGAAALLTVELDKE 4138
            ||..:.|:|.:.|.::                |:...:.:.|||:.:|.:|..|:|...||:|::
Mouse   477 FYGGDCYLVLYTYDVN----------------GKPHYILYIWQGRHASRDELAASAYRAVEVDQQ 525

  Fly  4139 -KGA--QMRVSQGDECTAFVRLFRQM-------WQHRGRKEQCLERHSEWRLYQLQGNVSEETII 4193
             .||  |:|||.|.|...|:.:|:..       ...:|.:|.    ....||:|:.||....|..
Mouse   526 FDGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNEEP----DPPVRLFQIHGNDKSNTKA 586

  Fly  4194 KEVVCQSSHLRSRSSMLLIHGSQGNVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKDLFSAETANL 4258
            .||...:|.|.|....||  .:|....:|:|..|:...|    .:|::|:     ||..  ..|.
Mouse   587 VEVSASASSLNSNDVFLL--RTQAEHYLWYGKGSSGDER----AMAKELV-----DLLC--DGNA 638

  Fly  4259 TEVEEGSDDDQCKKALGLK-----DERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKALELSDPL 4318
            ..|.||.:..:....||.|     |:|.:..:|       |.|:|:|..|:..|.|...|::|
Mouse   639 DTVAEGQEPPEFWDLLGGKTAYANDKRLQQETL-------DVQVRLFECSNKTGRFLVTEVTD-- 694

  Fly  4319 RCQDLHSPYPFSQSQLYNARQP-TIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGVN 4382
                      |:|..|    .| .:.|||..|:::||:|                      |..|
Mouse   695 ----------FTQEDL----SPGDVMLLDTWDQVFLWIG----------------------AEAN 723

  Fly  4383 RWISERRAALETAVDYWRAKH--GENENEPFHGIKGQVVWAGLEPLAFKALF----PD-WTERPD 4440
              .:|::.||.||.:| ...|  |.:.:.|...||     .|.||..|...|    |. |:|...
Mouse   724 --ATEKKGALSTAQEY-LVTHPSGRDPDTPILIIK-----QGFEPPTFTGWFLAWDPHIWSEGKS 780

  Fly  4441 VREINEEDG------RTDASISIATMLAQMTQTE---YPLEVL---KARPLPEGVEPTRLEVYLN 4493
            ..::..|.|      |..|.:..||:....:..|   ||:|||   :.:.|||.|:|.:.|.||:
Mouse   781 YEQLKNELGDATAIVRITADMKNATLYLNPSDGEPKYYPVEVLLKGQNQELPEDVDPAKKENYLS 845

  Fly  4494 AEDFQAALGCSRAEFEQLPIWKQTKLKKERGLF 4526
            .:||.:..|.:|.:|..||.|||.:||||||||
Mouse   846 EQDFVSVFGITRGQFTALPGWKQLQLKKERGLF 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	29/118 (25%)
		gelsolin_like	3859..3965	CDD:200436	23/115 (20%)
		ADF_gelsolin	<4069..4158	CDD:301701	26/91 (29%)
		gelsolin_S5_like	4176..4279	CDD:200444	29/107 (27%)
		ADF_gelsolin	4328..4435	CDD:301701	30/114 (26%)
		VHP	4492..4526	CDD:280388	17/33 (52%)
Avil	XP_006513161.1	gelsolin_S1_like	36..147	CDD:200446
		gelsolin_S2_like	162..282	CDD:200445	29/117 (25%)
		gelsolin_S3_like	306..404	CDD:200448	27/137 (20%)
		gelsolin_S4_like	448..548	CDD:200449	31/140 (22%)
		gelsolin_S5_like	569..658	CDD:200444	28/101 (28%)
		gelsolin_S6_like	676..771	CDD:200447	36/140 (26%)
		VHP	843..878	CDD:128458	18/34 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920