DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Svil and LOC100496020

DIOPT Version :9

Sequence 1:	NP_001286919.1	Gene:	Svil / 38306	FlyBaseID:	FBgn0266696	Length:	4526	Species:	Drosophila melanogaster
Sequence 2:	XP_017950415.2	Gene:	LOC100496020 / 100496020	-ID:	-	Length:	715	Species:	Xenopus tropicalis

Alignment Length:	796	Identity:	175/796 - (21%)
Similarity:	304/796 - (38%)	Gaps:	214/796 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  3677 SGIAERELR-RLKLESYGHNANLAAEAIAGLASVEDFKSVALRSSSIPLQQMWLPHKPVMLLHVK 3740
            |.:..|||: ....|..||..:.......|:||  .|:.|.....|..           .|||:|
Frog    90 SPVQYRELQGHESTEFLGHFKDGIKYQAGGIAS--GFQHVITNDLSAR-----------RLLHIK 141

  Fly  3741 GRTHVQTRLVEPVHTSLNRGDCFILVAGSQLFRYVGSFANVIEISRSKKICAAIVENKDLGCTAT 3805
            ||..|:...|....:|.|.|||||:..|.:::::.||.:|..|..::.::..:|..|
Frog   142 GRRVVRATEVPLSWSSFNSGDCFIIDVGPEIYQWCGSKSNKYERLKAAQVATSIRNN-------- 198

  Fly  3806 QEVILTDGKYLKERQWR-------QF------WQLLG-----KKEDDQSDIAECGHADEDDVFES 3852
                        |||.|       ||      .|:||     .:.||.:|:..       ||...
Frog   199 ------------ERQGRSNLTVVEQFSEPPSLMQILGPMPVLPEGDDDTDVTA-------DVTNR 244

  Fly  3853 SLIETNKIYEYQDEA------LIPLEKFWGCIPKVDMLDTRKVLVFDFG-SELYVWNGKNAPSDA 3910
            .:.   |:|...|.:      |:..|..:    .:.||.:.:..:.|.. .:::||.||.|..:.
Frog   245 KMA---KLYMVSDASGTMQTTLVSEENPF----SMPMLLSDECFILDSSDKKIFVWKGKGANVNE 302

  Fly  3911 KRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTKYAKRCAQRPEWCVLGKITQNMETV 3975
            |:.|::.|::             ::..:||                   |....:..:.:..||.
Frog   303 KKHAIKTAED-------------FIKKMNY-------------------PATTQIIVLPEGGETP 335

  Fly  3976 LFKEKFSDWPEIER-EDLEKDYLSNGVHMVRAL--NGTALHKGEPYQEPNLVLEQANLGRGNFYY 4037
            :||:.|.||.:.|: |.|.|.:....:..:..:  :.|.||........:.:|:.   |.|
Frog   336 IFKQYFKDWKDKEQSEGLGKVFTKEQIAQIEQIPFDATKLHTSARMAAQHNMLDD---GSG---- 393

  Fly  4038 DTDTMRHFDVITKSTDKWQIHEFNFDAANNRDDYGHFYSAESYIVRWIYQISVTVRELSGKVSNR 4102
                  |.::       |:| |.|.....:.:.||.||..:.||:.:
Frog   394 ------HVEI-------WRI-EKNARVPLDPETYGQFYGGDCYIIMY------------------ 426

  Fly  4103 STVGRDRCVYFTWQGQDSSANEKGAAALLTVELDK--EKGA-QMRVSQGDECTAFVRLFRQ---- 4160
            :|:...:.:| ||||.::..:|...:|.|||:||:  :.|| |.||.||.|....:.:|:.
Frog   427 TTLNGQKIIY-TWQGANAGKDELTYSAFLTVQLDRSLKAGATQTRVPQGKEPAHLLSVFKDKPLI 490

  Fly  4161 MWQHRGRKEQCLERHSEWRLYQLQGNVSEETIIKEVVCQSSHLRSRSSMLLIHGSQGNVIVWHGS 4225
            :::....::.........||:|::.|:...|.|.||...::.|.:..:.:| .....:.::|.|.
Frog   491 IYKDGTSRKGVQAPPRPIRLFQVRKNLGSITRIAEVDADATSLNANDAFVL-KMRDNSAVMWIGK 554

  Fly  4226 KSAPHTRNVAVGVAQDLIKTVPKDLFSAETANLTEVEEGSDDDQCKKALGLKDERNEYGSLLKST 4290
                       |..:|.|:.. |.|..........:.||.:.|.....||.|  :....|.|..|
Frog   555 -----------GANEDEIEGA-KYLVKVLNLRAINIAEGEEPDIFWTTLGGK--KTYQTSPLLET 605

  Fly  4291 KSFDYQIRIFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQLYNARQPTIFLLDDGDELWLWM 4355
            :..|:..|:|..|:..|.|...|:           |..|:|..:   .:..:.:||..::::||:
Frog   606 RLEDHPPRLFGCSNKTGRFVVEEV-----------PGEFTQEDM---AEDDVMMLDTWEQIFLWI 656

  Fly  4356 GWWPLEDVKINTDERSSPTNENRAGVNRWISERRAALETAVDYWRA-KHGENENEPFHGIKGQVV 4419
            |               ...||         .|::.:|.:|..|.:. ..|.:::.|...:|
Frog   657 G---------------KDANE---------VEKKESLVSAKKYLQTDPSGRDKDIPITTVK---- 693

  Fly  4420 WAGLEPLAFKALFPDW 4435
             .|.|||:|...|..|
Frog   694 -QGNEPLSFTGWFLAW 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Svil	NP_001286919.1	gelsolin_S2_like	3733..3825	CDD:200445	28/104 (27%)
		gelsolin_like	3859..3965	CDD:200436	19/112 (17%)
		ADF_gelsolin	<4069..4158	CDD:301701	27/91 (30%)
		gelsolin_S5_like	4176..4279	CDD:200444	23/102 (23%)
		ADF_gelsolin	4328..4435	CDD:301701	22/107 (21%)
		VHP	4492..4526	CDD:280388
LOC100496020	XP_017950415.2	gelsolin_S1_like	8..119	CDD:200446	7/28 (25%)
		gelsolin_S2_like	136..223	CDD:200445	29/106 (27%)
		gelsolin_S3_like	244..343	CDD:200448	24/137 (18%)
		gelsolin_S4_like	387..484	CDD:200449	35/136 (26%)
		gelsolin_S5_like	507..595	CDD:200444	23/102 (23%)
		gelsolin_S6_like	611..709	CDD:200447	30/141 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1376537at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010