DRSC/TRiP Functional Genomics Resources

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Protein Alignment Svil and svilb

DIOPT Version :10

Sequence 1:NP_001286919.1 Gene:Svil / 38306 FlyBaseID:FBgn0266696 Length:4526 Species:Drosophila melanogaster
Sequence 2:XP_073786498.1 Gene:svilb / 100322182 ZFINID:ZDB-GENE-081104-411 Length:2905 Species:Danio rerio


Alignment Length:3441 Identity:857/3441 - (24%)
Similarity:1344/3441 - (39%) Gaps:870/3441 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1412 HFHHHTT---PAYYTDLQLRIHTP-----NASDVGALNENYRSVYSTPSTQLVEQ--RSFPKSST 1466
            ::.:|.|   ..:.::...:|::|     .|...|..:.| ..|.||  |.:.|.  ...||.|.
Zfish     9 NYLNHVTQCSQGFVSEASAKIYSPALLKKRAVSFGVDDRN-SLVRST--TDIDENILAVLPKVSE 70

  Fly  1467 ATKDPPLPI-SNP--------ARGTFFRGDSASSDSHSRLRRSQQRTGS-------EGRFFRYSQ 1515
            ..|.....| |.|        ||    |.:...:|..:.|..|.|.|..       |....||::
Zfish    71 LRKQFETSIRSGPEMNRKERIAR----RLEGIETDVPAALNTSMQHTAGLVTNRLLEEDTPRYTR 131

  Fly  1516 GSVSPTKGEPPIGHEGGEQPPVVASHS--PITSTSTTTISSCNPVEQAS--PPPTNVVNPSGSGR 1576
            .|            :..:|..||..:|  .|.:....:.:...|..|.|  |.|.| ..|.||..
Zfish   132 AS------------DPSDQGIVVRRYSREEIEAPERQSRARTRPDPQPSTHPVPAN-PTPPGSDA 183

  Fly  1577 NSRHKQRFHSRSRRAVRVRSE-SRPISALYDIIC-KEKNLENSSSSSSSSNEQEKKKDQEQPKTT 1639
            ..       |::.|..|.::| .|.:|..|.|:. :|.:|:.:...:.:..|.:          .
Zfish   184 TG-------SKAERIARYKAERRRQLSERYGILLDQEVDLDYAPRYTRARRESD----------L 231

  Fly  1640 TDKLATFWPLHHHYLNPPMSSGNSGGSSGNPKQQQQQQQQQQLEQLGHQTHLVLGASKELPAVSS 1704
            :::.|           ||........:.|...|.|::.:.:               |......||
Zfish   232 SERGA-----------PPDRGRGESRTRGGALQDQEEGRDR---------------SSSRSKYSS 270

  Fly  1705 SSDEEGSLRTLHSSRKVTNLNAKSTSLPPEEGLSGDVSLESSSNRLNLRLA--RSLEPSVRNITA 1767
            |    |..|...||....|      ..||..|:..:...|.:.|..|.|.|  ||.:|..:....
Zfish   271 S----GMGRVFMSSDPTPN------QAPPPSGIDAERERERAMNLENYRRAPDRSSKPHPQETPM 325

  Fly  1768 SASKEVQSYDAGEPVNTNRLFVEPPKIPLSAIRNSLDDHDLDIEECDSTTQF--DQGDIYDTLER 1830
            ..|       |.:|.. ....:.....|.:|.|.||           .||::  ..||::  :|:
Zfish   326 ETS-------AAQPTR-GVAVITVASSPRTARRASL-----------PTTKYGISPGDLF--IEQ 369

  Fly  1831 WSHGV--SLGAHLLNCANGHDQSDPEDDHQTDHHQHAHQSLPVEPKSHHHQHHQATNARRFITRT 1893
            .:..:  ..|...|:      ||:.......|...|:..:.|...:....|              
Zfish   370 QAQNILNRQGLAALS------QSEWSLRRDVDSETHSQINWPSRIRVRERQ-------------- 414

  Fly  1894 TRSASRQSSAGHSPPPPLHRSDDSSSSSPSPTRRRNKPGGAPAATDPPSSSANGNSSAYETAATT 1958
                :|:..:|        |..||...:||.   |..|..||....|...|||            
Zfish   415 ----TREDISG--------RGSDSGPDTPSV---RRHPTVAPPYLAPRPQSAN------------ 452

  Fly  1959 VMTHDQQRDPPVEVPKALNVEPPQPEDIVLGSCPTASAHSAESQSRGKAGKCSINCTYSHSHSTN 2023
             ....:..:||::       :|.|..|     .....|||||..            .:..:||.:
Zfish   453 -QPRTRSTEPPIQ-------QPSQGMD-----ARQQRAHSAERP------------RFQRTHSMD 492

  Fly  2024 NNCNARQRNSSNISSNNTISSNSSSSKSTCNNNSKQQHATPMPPLANANKAPLIVLKTAASAAAL 2088
            :.                 :...:.|....|::||.:.                          :
Zfish   493 SP-----------------AFQHTPSGGMTNHSSKYEQ--------------------------I 514

  Fly  2089 PSIAAAATSSGTAATSGGVGSPIKRRKNPLSPLLLGSQCQSTIAPPQAIASPLLSGGSCSSSTTS 2153
            ||:  ..::.|.....|.:..|:.:|         |||   ....|..:..|            |
Zfish   515 PSV--HPSTMGHQPGFGQMKQPLPKR---------GSQ---DAQQPSQMHRP------------S 553

  Fly  2154 PQSSPAVRTTK------------ASRLRAAALDKKKEEEQRNRYSSPVSPKASSNGGVQAQRRLS 2206
            .|..||.:..:            ..:.||.......:::.|    .|:.|:..:...:..:.::.
Zfish   554 QQPHPAYKDLQQPLPGHRDAPPPVQKYRAILQPVPLDQDTR----QPIQPQVPTQKPLHEREQIL 614

  Fly  2207 NSELSPKSPGASGF----------TSEPVASATANRVPTRSASHPVDTPPTQRRQPLVAVSSGIS 2261
            :|.|   |.|..|.          |..|....|.:.||:..:||   .||.....|.:|....:|
Zfish   615 HSRL---SHGHYGHNQPLQYGPVQTLPPAYGQTVHSVPSHVSSH---LPPPNSHVPHLAPEPPLS 673

  Fly  2262 MKQSLS-ELHFTGGAV-SPPKATAECTLR-----MRP-----RSSTMSTENTENGRRDHLANLQL 2314
            ..::|. :.|.:..:: |..|...|..||     ::|     ||:|.:...:|...:...|.|. 
Zfish   674 RSETLDPKGHMSSSSLTSADKEVKENRLRTNADHIQPTQREGRSATRTNPPSEGLLKSRKAVLP- 737

  Fly  2315 SPVQKQKRTPEVSPRRFGDRDKSAKRKSNLNRS-LTEEAT------KDGDEVASSTRRRRRRELG 2372
            |.:::::::.:...|...|....::|...::.| .|||.:      .:|.|....|...|..|.|
Zfish   738 SEIRRRQKSVDDPMRGQSDEGLESRRIRRISHSDETEEKSGRMLHQLEGREGPVGTGITRMEEGG 802

  Fly  2373 M-ARPLVPGDDDALRDLLTPQKSSCSESTNSISEPHLQFIPAVRHPVVPVRTMTAVLPAPRPLHT 2436
            | :..:|.|   .|:|      ..|.:...|                                 .
Zfish   803 MISGEMVIG---ILKD------RGCDDRRTS---------------------------------Q 825

  Fly  2437 PAARNVSQKFNERTKTDLAE-----IKKIAEQSEAQVQQPSVDDNQKMSAIMR-RKSTDEGGSAL 2495
            |..|.:.   |..||..:.|     ::||.::.:.          :::|.|.| .:|:|...:.|
Zfish   826 PEKREID---NGTTKIWIGEEVERGVRKIGQREKI----------KQVSGIKRDEESSDWNTNRL 877

  Fly  2496 GATNQNSPPAPNQIVSILKKKE----------------HGLGECNSSASSNPSPVTFSSSVVD-- 2542
            |...|.|....|:    .|::|                .|:.........|..   |....|:  
Zfish   878 GEIEQGSAKKVNE----FKEREWEVDRKKGQVIHTVEPQGVKTVRQEVQENQK---FLQKDVEEN 935

  Fly  2543 -------HPLAG-AGRCKRQGILKKRSSLDESRYYSRSHSPDERSILIKSARRNSLEE------- 2592
                   :||.. .|..:|:.|.:..... |.|...:....|||.:.:...:..:||:       
Zfish   936 HGRRRQINPLENEEGHVRRRRISQSEDDW-EGRRVRKIGQLDEREMQVVQDQLEALEKGKQRLNI 999

  Fly  2593 ------AGTGLSPA----QAHGILKQSSYDSSKSDGCPSATE--SQPHSILKKKDSLSTPSDGGC 2645
                  |.|.:.|:    .||..|.||.....|....|.|..  ||....|:.|..:.:.||.|.
Zfish  1000 PKEMDTAPTQVQPSNEQPSAHHRLGQSGGYLLKGSSLPQAQHRVSQDAGDLRPKVRIRSMSDIGV 1064

  Fly  2646 HKHVSISQAVTLAAA-------ELAAH----DGITFDDGE-------------EHEI-------R 2679
            .:..:..:::..||:       ...:|    .|:.  :||             .|..       |
Zfish  1065 TQRSAALRSLERAASRESVMLMNAGSHTRDLGGVA--NGEMGTLDTRVSVAKLRHSYLENASGRR 1127

  Fly  2680 PILKQE------------STSSEEAVRPPK----PILKKKSFGEADEHEIRPI-----LKSSRKS 2723
            |.|:.:            |...:...|.|:    |...:||   ::....:||     ::|.|..
Zfish  1128 PELESKGDQVPVEPDPVVSPDRDRGTRRPRRYISPSDDRKS---SERFRTQPITSAERMESDRSR 1189

  Fly  2724 SREEFDLSGLENEVNDSLSSILKTDSPSKRRSLGSALHDLEESTTSPSMLKRRTR--SLERQDVQ 2786
            ...||..|.|:.|..|..:.:    |.:.:|||...|    |.|:..::.|.|:|  ::||:   
Zfish  1190 LSPEFQHSNLDEEKMDERAKM----SVAAKRSLFREL----EKTSDGTVPKPRSRNAAVERR--- 1243

  Fly  2787 PGMDLAAALDAIATSQATPSTPVDFVTTPTSIS-------VAERIKRMEMLSTPTSRAAGGANSS 2844
                |..|.|...|...|....|..||:|...|       .|.||....::||          |.
Zfish  1244 ----LRRAQDRSRTQPVTTEEVVIAVTSPAPPSQVIPVHTTAPRIPSPAVVST----------SM 1294

  Fly  2845 WESPLQASSAEHGAPTTPRVLKPSVLRR--DLQRERYKTQPVTN-----EEMSFFKANSAPFDIS 2902
            ....||||||:..|.....  |..||:.  ..:||....:|..:     |:|:.|...|.|.|.|
Zfish  1295 TSFSLQASSAQESAHQEQE--KEDVLKEVGPEEREAGPDEPDLSALSLAEKMALFNRLSQPTDQS 1357

  Fly  2903 ATSAFKPTKPLDIRLTHAPHAPLISPITGQPLSHVPAPLLLSSSTNSGAGSSFRLARSSTQPLQS 2967
            |                  :.||  |.|.|..::                     .|..|||:..
Zfish  1358 A------------------NGPL--PDTRQRRAN---------------------TRFQTQPITQ 1381

  Fly  2968 PRV-VHLAGQATGGSALARQNSVNDSIN-LSEQLTLSIGTDSEHIFEMSALEEDSAIQSLSDETA 3030
            ..| ..||......|...|...:|||:. ..|||.    ..|..:..:||    |.::|::..||
Zfish  1382 DEVDQELAKDIDPSSLTGRPAVINDSVGPQGEQLQ----NGSMKLEPLSA----SLVRSVTAVTA 1438

  Fly  3031 ASASANSTSTTTATT--------MTPPSGLTRSNSVR-------ARANMFQQLQEQSRNQRATGT 3080
            .::.|...|.:.:.|        :.|||.....|...       .|...:..|.|...|.    |
Zfish  1439 QASVATLASASPSMTADVRMGMPVAPPSTQASPNQTAPAPLPAYERGVRYFSLTESGENP----T 1499

  Fly  3081 TNSRQSPPA--------SSAEVSSSAADNSMHSDERSTPNATIDAEFGKPST----EPLKSILKT 3133
            .:.:..|||        |....:|..|:|......|:......:.|...||.    .|.     |
Zfish  1500 PDVQSPPPAEPFSQSPHSKGGAASIPANNESGQRGRAGYLGREEREADLPSAASPPHPF-----T 1559

  Fly  3134 GMPVMGMGRGLMPVDLNAEL---KNRLKRSTHATVSNLRKSATSADA--------TRAASDEVDN 3187
            ..|..|.|        :|||   ::..|..|:      ::...|.||        |||...:|.:
Zfish  1560 HTPPHGRG--------DAELSGPRHWEKDGTY------KEGYLSPDAQYTARGANTRAIVSDVPD 1610

  Fly  3188 PQRNLAQILRNVSKENSTPKHDDAVSLVRNLSTLGQPRSLARDDAAGNCASASEGES-SGGREIE 3251
            |...:..:....:...|:.:...::|   :|.:...|:...:........:..:.:. |.....:
Zfish  1611 PSVPVRALSSTAASSRSSSQTTHSLS---HLQSYTPPQPQPKPAQHPQIYTRPQTQPYSPPTPSQ 1672

  Fly  3252 AIIKNSAVARRRRQQQQQSQQQNQPDGNLVAKSKSHSGISAPIGLGPQ--------LPPLPLGGG 3308
            .:..:...|....|:|.:...|.||........:||:.||.|..:.||        :||.|    
Zfish  1673 TLHPDVHPAYHDLQRQTRVPPQTQPKPQPFLPPQSHAYISPPPKIPPQTQPKPQCFIPPQP---- 1733

  Fly  3309 FVKLRHVAKEEDTSSSSNTSSAKESPDKKDLRQEQAEASGDSSHPTALPQFLQGVQRSSTEVMGP 3373
                     :|:.......|.|..|.:.|...||..||.      |::                 
Zfish  1734 ---------QEEIVGKYGPSGAAVSKEPKPEVQEDPEAM------TSM----------------- 1766

  Fly  3374 DQRSLVISKTGSIAERLAALHKSGEDDWKKRISKRDEV----------------DDVHRENFVNE 3422
                       ||.||||.|.||||:|||.||:|:.||                :....|.|..|
Zfish  1767 -----------SIKERLAMLKKSGEEDWKNRINKKQEVIQEVASASEKSGPIWEEQKKDETFTRE 1820

  Fly  3423 SLS--------LAHSLSDKPLPPSPLIP------TSLEGGK----VSDRLSKLKCNSENWK--QR 3467
            ..|        .:.:.|..|||.:|...      ..||.|:    :.:|...:....|.|:  .:
Zfish  1821 FKSSEQLWEPVFSSTYSPPPLPSTPKCQYVEHQGQKLEEGEGQMSIEERKQMISTREEAWQCTGK 1885

  Fly  3468 IEQTDAKKFTVAGRLQKKAQSPVELQFERSANDAAKKCPMLEVRSANQPQLGLAKSPSMMVTSST 3532
            ....|:.::|||.|:.||                                 |||.|.:::....:
Zfish  1886 GVANDSAQYTVAARMVKK---------------------------------GLAASSAVISPILS 1917

  Fly  3533 STNSTSKSALRSLSVNPEEEGPTSLSRSNSSSSESDGERKSPQNAKQNKELANNKSAAAPTNVGA 3597
            ..::..||:|..:| .|:||    :.......|:...|:......:.|.:::..:.........|
Zfish  1918 PVSAKLKSSLPGIS-KPQEE----IEARAEMESDKKLEKLETFLGRLNSKVSGLQETTLTVTEKA 1977

  Fly  3598 RIQVPRLDDKETFENFF----------SSKPKKEENVQLEISAFDDI--KPTERLVS-----KRH 3645
            ..:|.|||| |.|..|:          ||:...:|:       ||.|  |.|..|.|     ||.
Zfish  1978 VKEVMRLDD-EIFSKFYRHMTDIPRTMSSRMHLDED-------FDAIFGKQTTMLTSAMVQHKRA 2034

  Fly  3646 VQGPKGRRAARNPLKSLAAREDISSEYTEMRSGIAERELRRLKLESYGHNANLAAEAIAGLASVE 3710
            |:..:..:|:|||||.||||:||..||||.|..:.:.|.:|:|.|....:::|:..|:|||||.|
Zfish  2035 VRPSRNVQASRNPLKILAARDDIRQEYTEQRLNVGQLESKRIKQEKMSKSSSLSDAALAGLASKE 2099

  Fly  3711 DFKSVALRSSSIPLQQMW----LPHKPVMLLHVKGRTHVQTRLVEPVHTSLNRGDCFILVAGSQL 3771
            .:.||:|||.||. :||.    .|:|.:||:.||||.|||||||||..:|||.||||:||.....
Zfish  2100 SYSSVSLRSVSIS-EQMTNNSAAPYKKLMLMQVKGRRHVQTRLVEPRVSSLNSGDCFLLVTPEHC 2163

  Fly  3772 FRYVGSFANVIEISRSKKICAAIVENKDLGCTATQEVILTDGKYLKERQWRQFWQLLGKKEDDQS 3836
            |.::|.||||||.:::.::...|..|.||||.|.....:.:|...:.....:||:::|.....| 
Zfish  2164 FVWIGEFANVIEKAKASELATFIQLNHDLGCRAAFVETIEEGVNAQSSAATEFWKIIGGPASYQ- 2227

  Fly  3837 DIAECGHADEDDVFESSLIETNKIYEYQDEALIPLEKFWGCIPKVDMLDTRKVLVFDFGSELYVW 3901
               ..|..|||::|||:::|||.|:...|:.|:|.:.|||.:|:..:|.:::|:|||||||:|||
Zfish  2228 ---PAGSPDEDELFESAIVETNCIFRLVDDRLLPDDDFWGKVPRSTLLGSKEVIVFDFGSEVYVW 2289

  Fly  3902 NGKNAPSDAKRAAMRLAQEHFGAENSADYADCYLNPLNYVAIVGRRENTKYAKRCAQRPEWCVLG 3966
            :||......::.|.:||:..:  ..:.||.:|.:|||:     ....||...::...||:|.:.|
Zfish  2290 HGKEVTLAQRKVAFQLAKHLW--NGTFDYTNCDINPLD-----PGGHNTLIPRKGQGRPDWAIFG 2347

  Fly  3967 KITQNMETVLFKEKFSDWPEIEREDLEKDYLSNGVHM------------VRALNGTALHKGEPYQ 4019
            ::|::.||.||||||.||.:..|.. .|:.:.:....            .||.:.:.:.  ...|
Zfish  2348 RLTEHNETSLFKEKFLDWRDPSRLS-PKNVIEHPFQQKVECPPADCGSECRAYSASLML--PVLQ 2409

  Fly  4020 EP-NLVLEQANLGRGNFYYDT---DTMRHFDVITKSTDKWQIHEFNFDAANNRDDYGHFYSAESY 4080
            .| :.:|:..::|||:...:.   |.:|..::.|.|.|.|.|.||::... .:...|.|:..::|
Zfish  2410 SPISTILDGQDVGRGHGPVENSSDDCLRSLEISTVSVDVWHILEFDYSRL-PKQSIGQFHEGDAY 2473

  Fly  4081 IVRWIYQISVTVRELSGKVSNRSTVGRDRCVYFTWQGQDSSANEKGAAALLTVELDKEKGAQMRV 4145
            :::|.|.:|..|..........:..||::|.||.|||::||.:|||.:||:|||||:|:||||:|
Zfish  2474 VLKWKYMVSAAVGSRQKPDQRSAGPGREKCCYFFWQGRNSSVSEKGTSALMTVELDEERGAQMQV 2538

  Fly  4146 SQGDECTAFVRLFR-QMWQHRGRKEQCLER-HSEWRLYQLQGNVSEETIIKEVVCQSSHLRSRSS 4208
            .||.|...|::.|. .|..|.|::|:..|. .::||||.::|.|..|..:.||.|..|.||||:|
Zfish  2539 QQGKEPPCFLQCFNGGMIVHSGKREEEEENIQNDWRLYCVRGEVPVEGHLLEVACHCSSLRSRTS 2603

  Fly  4209 MLLIHGSQGNVIVWHGSKSAPHTRNVAVGVAQDLIKTVPKDLFSAETANLT--EVEEGSDDDQCK 4271
            |||::.::..:.:|||.|:..|:|:||...|..:.:..|.:.....:.|:|  |.|||.:..:..
Zfish  2604 MLLLNINKALIYLWHGCKTQTHSRHVARTAADKIKEQRPLEAGLHSSCNVTIHECEEGGEPVEFW 2668

  Fly  4272 KALGLKDERNEYGSLLKSTKSFDYQIRIFNFSSTQGVFKALELSDPLRCQDLHSPYPFSQSQLYN 4336
            :|||.|| |..|..:|:....|::..|:|..:|:.|.|.|.|..:|.|..||....||.|..||:
Zfish  2669 EALGRKD-RKAYDCMLQDPGKFNFTPRLFQLTSSSGEFVAQEFFNPSRAADLVCSLPFLQEDLYS 2732

  Fly  4337 ARQPTIFLLDDGDELWLWMGWWPLEDVKINTDERSSPTNENRAGVNRWISERRAALETAVDYWRA 4401
            |.||.:||:|:..|::||.||||.:            |....:...||.|:|:.|:||.:.|.|.
Zfish  2733 APQPALFLVDNYHEVYLWQGWWPQD------------TESTGSARIRWDSDRKCAMETVLQYCRE 2785

  Fly  4402 KHGENENEPFHGIKGQVVWAGLEPLAFKALFPDWTERPDVREINEEDGRT-DASISIATMLAQMT 4465
            |   ||.:|   .|..::.||||||.|..:||.|..|.|:.||.|.:... :..|.:..:||::.
Zfish  2786 K---NEKKP---QKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEREAEVCNQIILVEDVLARLC 2844

  Fly  4466 QTEYPLEVLKARPLPEGVEPTRLEVYLNAEDFQAALGCSRAEFEQLPIWKQTKLKKERGLF 4526
            |:.||||.|:.||||.||:|.:|||||..|||:..|...|.||:.||.|||..|||.:|||
Zfish  2845 QSTYPLETLQTRPLPHGVDPLKLEVYLTDEDFERVLDIKRDEFDALPGWKQVNLKKAKGLF 2905

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SvilNP_001286919.1 gelsolin_S2_like 3733..3825 CDD:200445 40/91 (44%)
gelsolin_like 3859..3965 CDD:200436 36/105 (34%)
ADF_gelsolin <4069..4158 CDD:472830 37/88 (42%)
gelsolin_S5_like 4176..4279 CDD:200444 39/104 (38%)
ADF_gelsolin 4328..4435 CDD:472830 42/106 (40%)
VHP 4491..4526 CDD:460493 18/34 (53%)
svilbXP_073786498.1 None

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