DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9004 and Y52B11A.10

DIOPT Version :9

Sequence 1:	NP_647717.1	Gene:	CG9004 / 38303	FlyBaseID:	FBgn0035336	Length:	854	Species:	Drosophila melanogaster
Sequence 2:	NP_492861.1	Gene:	Y52B11A.10 / 173006	WormBaseID:	WBGene00013129	Length:	819	Species:	Caenorhabditis elegans

Alignment Length:	875	Identity:	253/875 - (28%)
Similarity:	427/875 - (48%)	Gaps:	127/875 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KAKPLTRKEQRKQKSEFKKQNKRLYFAGKTNGTQRVAAAAEALAAQSQLGKNKKKKRSKKPKIIN 74
            |...::||||||...:.||...:.:       :|| ....:.:.....:.|..||||.:|.::..
Worm     7 KKDGMSRKEQRKSAKQLKKMQAKAF-------SQR-TPIEQVMRETMGMTKEDKKKRKRKRQLEA 63

  Fly    75 PDEIPKEQLLSGEIDSDDDESIDSDFSDAEVDALLPAREKMEVYEPLGKKVKKTTGGAIQRQDEE 139
            ..|..|.:.|..:..:|.|...:.|..|:|.:.......:..:.|....|.|:..|...:..||:
Worm    64 KKEQRKLEYLQNKNRNDGDSDDEEDMEDSEDEEEKKPTNRKGIVEVSVNKGKRKYGDDSEDSDED 128

  Fly   140 AVRRKELRQQKELESKSKKQRIKQLRIENEEDDREINKLEKKLKLNKSK----DKNRLVRKMFND 200
            ....:.:   :|:::.:||:|  |.....||||..|.|....|.:|:.|    .|.::.:.|.:|
Worm   129 LTYEQYM---EEVQTATKKRR--QEADGTEEDDAAIRKYGVLLGVNEQKKERDGKLKVPKSMKSD 188

  Fly   201 GLDYLLDFVLDDEEEKRKWEEKQERKKKLKEQQEKEEAGMWSDEEEDKEDRDEPMDNFSEDDSG- 264
            |||.||||.            ..||:|:|.| .|.::..| .||||.:::.||      .|:||
Worm   189 GLDLLLDFC------------DSERRKELME-DELDDDNM-EDEEEFEDEEDE------ADESGN 233

  Fly   265 ----SEGE-----DDDEDLTGEEEQSEE------------DSEQEENAPKIK---EDIYGRK-RD 304
                ||||     :||||:..|....||            |||.|.:|||..   ||||||| ..
Worm   234 ELDLSEGEEPVESEDDEDMVDEMMSDEEDNVDDEKIVEISDSEIETSAPKKSEETEDIYGRKINK 298

  Fly   305 AEGNILP-DPVELEASAAGQKYIPPHQRALMAASAGSSEKQAEILARLLKQCKGLLNRLSEANLH 368
            :.|.::. ||      ||.:|.:    ..|.|.|:...:||     |:.:....::|:||:|.|.
Worm   299 STGELIKFDP------AAARKKL----EELDATSSTGEQKQ-----RVERAVNSIINKLSDAMLI 348

  Fly   369 KIAAGIEELYMKNSRYNMNETLTKLIQEALLGYTRTNERMVQEHMVLLAYLHAQVGSEIGAHFLQ 433
            |...||.||:..:|:.::...|.|.:.:|||...|..:.::..:..|:|..|..:.:||.|||::
Worm   349 KSQQGIAELWANSSKNDVKSALYKFLSKALLAPFRLQDSLLTTYGALIAMCHTMISNEISAHFVE 413

  Fly   434 TFV-ELFDGYVKNI-ATLEVEDKQLNNLVLVLCYMYLFKIYELNLLMELIGKLSDQLCEKSVECL 496
            .|: :|    ||:: ...|::||.:.|.|:...::.:|:|.:.::|:|:|.||::.|   ::..|
Worm   414 CFMCDL----VKSMQEEEEMDDKSMENCVIFTAFLVVFRILQPSILIEIIDKLAENL---NLTNL 471

  Fly   497 LLIFQSIGFRLRKDDPLAFKTMMQK---VQSQIASAPLELKENPRLRFMVDILNAVKNNNMQKLP 558
            ..|...|.:..:.....::..:.||   :.|:....|:...  ||.:|:::.:..:|.:..:.:
Worm   472 FAIRTLIAYAYKSLKKTSWPLVTQKIDEIHSEFEKKPISAL--PRAKFLLEEVILLKKSPPKAI- 533

  Fly   559 QYDPELAENLRKRLKAMLKNDRYVVT-----LNITLEDLLRADKVGKWWIVGSAWT-------GN 611
              |.::.|...|.|..:.|......:     |::||.|||.|::.|:|||:|||:.       |.
Worm   534 --DYDVVERQVKILHGITKKKGSSASSDSKELSMTLNDLLHAEQRGRWWIIGSAFRLPEQGGYGL 596

  Fly   612 LDEMGSAKQKQDKNSSKSANGGFADQLLELARKQQMNTAERRNIFCIIMSAADYVDAFEKILHLS 676
            |....:|.||:        .|.|..:::.||.|..||:..||:|||.:.||.|..||||::|.|.
Worm   597 LASASAAGQKK--------TGSFPPEMVSLATKAGMNSEVRRHIFCSVASADDEDDAFERLLKLQ 653

  Fly   677 LK--DQRAVAYVIIHCALNEKRANPYYAHLALKFCQFNRKYQLAFQFASWDRINDIEKLSKPQIR 739
            ||  .:|.:.:|:|...:.||..|.:||.|..:||:||:::.:..|||.|||:.:.::|...|..
Worm   654 LKGEKERELVHVLIAMMMKEKTYNAFYATLLQRFCEFNKRFVITLQFALWDRLRECDQLKPFQRG 718

  Fly   740 NLASFLQQVILAAGLQLSVLKVVDFMQLDKLSFYFMKEVMVRLLLANDEREIYQTFERV---AKN 801
            :||..||.:|....:.::|||.|::..........:|::.:. |..:.|..:.:.||.|   .|.
Worm   719 SLAQLLQHLISNEVMSITVLKTVEWATRSARLTTILKKLFLG-LAKSPESVLKRVFEPVIDQQKR 782

  Fly   802 TKLQQFKQSVRLFLQHFLLQE----EQLDK 827
            ||.:...:.:|:| .|..|.:    :::||
Worm   783 TKFELLSEGMRVF-WHMNLNDFAAYQKIDK 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9004	NP_647717.1	MIF4G	352..553	CDD:280935	53/205 (26%)
CG9004	NP_647717.1	MA3	652..755	CDD:280933	42/104 (40%)
Y52B11A.10	NP_492861.1	Nop14	<231..>290	CDD:367841	20/58 (34%)
		MIF4G	332..529	CDD:367217	53/205 (26%)
		MA3	628..734	CDD:367215	42/105 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166450
Domainoid	1	1.000	84	1.000	Domainoid score	I5287
eggNOG	1	0.900	-	-		E1_KOG2141
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39776
Inparanoid	1	1.050	292	1.000	Inparanoid score	I1682
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53878
OrthoDB	1	1.010	-	-		D189414at33208
OrthoFinder	1	1.000	-	-		FOG0004175
OrthoInspector	1	1.000	-	-		oto18933
orthoMCL	1	0.900	-	-		OOG6_102915
Panther	1	1.100	-	-	LDO	PTHR18034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1329
SonicParanoid	1	1.000	-	-		X2926
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800