DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8993 and ERP44

DIOPT Version :9

Sequence 1:NP_647716.1 Gene:CG8993 / 38301 FlyBaseID:FBgn0035334 Length:142 Species:Drosophila melanogaster
Sequence 2:NP_055866.1 Gene:ERP44 / 23071 HGNCID:18311 Length:406 Species:Homo sapiens


Alignment Length:108 Identity:29/108 - (26%)
Similarity:59/108 - (54%) Gaps:10/108 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 EDFDKKVKNSQQPVIVDFFATWCNPCKLLTPRIE---SIVGEQ---AGSIKLAKVDIDEHSELAL 99
            |:.| ::.|:....:|:|:|.||...::|.|..|   .::.|:   ...:..|:||.|:||::|.
Human    37 ENID-EILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQ 100

  Fly   100 DYDVAAVPVLVVLQNGKEVQRMVGLQDEDKIRAWVAAAVKQAK 142
            .|.::..|.|.:.:||..::|  ..:.:..::| :|..::|.|
Human   101 RYRISKYPTLKLFRNGMMMKR--EYRGQRSVKA-LADYIRQQK 140

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8993NP_647716.1 Thioredoxin_like 39..138 CDD:294274 27/102 (26%)
ERP44NP_055866.1 PDI_a_ERp44 29..136 CDD:239294 27/102 (26%)
PDI_b_ERp44 144..234 CDD:239368
Interaction with ITPR1. /evidence=ECO:0000250 236..285
PDI_b'_ERp44 245..355 CDD:239370
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..387
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 403..406
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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