DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MsR1 and srw-34

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001023883.2	Gene:	srw-34 / 3565702	WormBaseID:	WBGene00005781	Length:	380	Species:	Caenorhabditis elegans

Alignment Length:	441	Identity:	91/441 - (20%)
Similarity:	169/441 - (38%)	Gaps:	119/441 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 YVSLVVCILGTIANTLNIIVLTRREMRS-PTNAILTGLAVADLAVMLEYIPYTIHDYILT----- 88
            |.:..|..:..|.|..::|||||:.||: |.:..:.|:.:.|...:..::...|.....|
Worm    44 YANFFVAAIALIPNFFHLIVLTRKSMRTMPIHIFIFGIGLCDFTRIALFLVMNIPQLWTTYQNLE 108

  Fly    89 --DSLPREEKLSYSWACFIKFHSIFAQVLHTISIWLTVTLAVWRYIAVGYPQKNRVWCGMRTTII 151
              |.:|   .|||......:|::|...|....||||.|.:||:|.:.:.||..:|:   .|.:.:
Worm   109 NPDCIP---PLSYFEMARNEFYTIAVSVCEQSSIWLGVVMAVFRTLLIKYPLSHRL---HRMSTL 167

  Fly   152 TITTAYVVCVLVVSPSLYLITAITEYVDQLDMNGKVINSIPMTQYVIDYRNELLSARTAALNATP 216
            ......::.:|::..||:    |.:|                    :.||..:..
Worm   168 KYKLLPIISILLIIISLW----IPKY--------------------LRYRIRIFG---------- 198

  Fly   217 TSAPLNETVWLNASTLLTSTTTAAPPTPSPVVRNVT--VYRLYHSDLALHNASLQNATFLIYSVV 279
                    :|.            .||......:|.:  :|.:..:.:.....:.||.||| ..:|
Worm   199 --------IWF------------PPPICDKFPKNYSQPLYFMEETKIFDGEITFQNLTFL-EGIV 242

  Fly   280 IKLIPCIALTILSVRLILALLEAKRRRKKLTSKPATPGASNGTKSPANGKAADRPRKNSKTLEKE 344
            ..|||.|.|.|.::.||:.|                       |.|:               ..:
Worm   243 FFLIPSIILPIATISLIIDL-----------------------KKPS---------------RSQ 269

  Fly   345 KQTDRTTRMLLAVLLLFLITEFPQGIMGLLNAVL----GDVFYLQCYLRLSDLMDILALINSSIN 405
            :..||:::::..:.:.|:|...|...:.::|.|.    |..|.|:|   :..:...|..||:|::
Worm   270 ENRDRSSKLVTFMTISFMIAMVPYSGLYIINFVQSKSNGIRFILRC---IEVIFSFLITINNSLH 331

  Fly   406 FILYCSMSKQFRTTFTLLF-RPKFLDKWLPVAQDEMAAARAERSAVAPVLE 455
            .:|...||.::|.....:| :...:|  :.::...|.:.|..||..:..:|
Worm   332 CVLCYLMSTKYREAVKSMFNKTNTVD--IQMSDQRMTSVRNPRSTFSVKIE 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	85/411 (21%)
srw-34	NP_001023883.2	TM helix 1	41..67	CDD:341315	8/22 (36%)
		7TM_GPCR_Srw	44..350	CDD:370978	84/407 (21%)
		TM helix 2	74..103	CDD:341315	3/28 (11%)
		TM helix 3	125..154	CDD:341315	11/28 (39%)
		TM helix 4	168..188	CDD:341315	4/23 (17%)
		TM helix 5	232..257	CDD:341315	12/25 (48%)
		TM helix 6	270..300	CDD:341315	5/29 (17%)
		TM helix 7	313..339	CDD:341315	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910