DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MsR1 and srw-123

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001023706.1	Gene:	srw-123 / 3565663	WormBaseID:	WBGene00005870	Length:	365	Species:	Caenorhabditis elegans

Alignment Length:	439	Identity:	83/439 - (18%)
Similarity:	149/439 - (33%)	Gaps:	177/439 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VCILGTIANTLNIIVLTRREMR-SPTNAILTGLAVADL---------------AVMLEYIPYTIH 83
            :.|...:.|.::..:|||:.|| |..|.::..:|..|:               .:..|.:....:
Worm    45 ISISSILINLVHFFILTRKPMRTSSINILMAAVAFFDIFTSLLPIEVLFERYKDIFFECLSLDTY 109

  Fly    84 DYILTDSLPREEKLSYSWACFIKFHSIFAQVLHTISIWLTVTLAVWR-----------YIAVGYP 137
            ..:||.:|....| .||..|               |.||...:|..|           |.|:|.|
Worm   110 GLVLTKALLTVVK-DYSRRC---------------STWLIFFIAFIRTLIIQNPLSSKYEALGKP 158

  Fly   138 QKNRVWCGMRTTIITITTAYVVCVLVVSPSLYLITAITEYVDQLDMNGKVINSIPMTQYVIDYRN 202
                     :.:||.||.   :||:.:..|::.... .::|:.:..:    :..|.|.|:::..:
Worm   159 ---------KASIIVITG---ICVVTLPISMFKFLE-NQFVESMPRD----SCAPNTTYIVNVLS 206

  Fly   203 ELLSARTAALNATPTSAPLNETVWLNASTLLTSTTTAAPPTPSPVVRNVTVYRLYHSDLALHNAS 267
            ||.                                          ::|..:...|.
Worm   207 ELF------------------------------------------MKNDGIVMKYF--------- 220

  Fly   268 LQNATFLIYSVVIKLIPCIALTILSVRLILALLEAKRRRKKLTSKPATPGASNGTKSPANGKAAD 332
                 :|..|.:..:||||.|.|:::.|:..|.:..::|.|::|      .||...|  .||:.
Worm   221 -----YLFNSSISDIIPCILLLIVTILLVWNLFKTSKKRTKISS------VSNNRNS--RGKSG- 271

  Fly   333 RPRKNSKTLEKEKQTDRTTRMLLAVLLLFLITEFPQGIM--------------GLLNAVLGDVFY 383
                                ::|.|.::|.:.|.|.|:.              .:||. .|.:|
Worm   272 --------------------LVLCVAIMFFVVECPYGLSVGSAWIFIHAPGAHNMLNQ-FGAIF- 314

  Fly   384 LQCYLRLSDLMDILALINSSINFILYCSMSKQFRTTFTLLF-----RPK 427
                       .:|..:|:..:.|:...||.|:|:|...:|     |||
Worm   315 -----------SMLITLNTCTHLIVCLFMSSQYRSTTIQVFSCGRIRPK 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	81/437 (19%)
srw-123	NP_001023706.1	7TM_GPCR_Srw	45..347	CDD:370978	80/432 (19%)
		TM helix 2	71..93	CDD:320109	3/21 (14%)
		TM helix 3	116..138	CDD:320109	8/37 (22%)
		TM helix 4	163..179	CDD:320109	6/18 (33%)
		TM helix 5	218..241	CDD:320109	9/36 (25%)
		TM helix 6	272..292	CDD:320109	6/19 (32%)
		TM helix 7	308..333	CDD:320109	6/37 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910