DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MsR1 and sprr-1

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_510555.2	Gene:	sprr-1 / 3564903	WormBaseID:	WBGene00010986	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	494	Identity:	119/494 - (24%)
Similarity:	202/494 - (40%)	Gaps:	122/494 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 MHGYVSLVVCILGTIANTLNIIVLTRREMRSPTNAILTGLAVADLAVMLEYIP-----YTIHDY- 85
            |:||:...:..|....|:..::||:.:.:|:|||.:|..:||.:|...|..:|     ||:..|
Worm    31 MYGYMMPFIVTLTVATNSFIVVVLSHKYLRTPTNYVLLAMAVTELLTGLSCLPWFTYYYTLSGYK 95

  Fly    86 -ILTDSLPREEKLSYSWACFIKFHSIF-AQVLHTISIWLTVTLAVWRYIAVGYPQKNRVWCGMRT 148
             .|...||     |: |...|.:.:.| ..:.||::|||||.||:.|||.:..|...|.:|
Worm    96 NDLQTGLP-----SF-WCDMIPYMAAFLPSIFHTMAIWLTVYLAIQRYIYICVPSLVRKFC---- 150

  Fly   149 TIITITTAYVVCVLVVSPSLYLITAITEYVDQLDMNGKVINSIPMTQYVIDYRNELLSARTAAL- 212
               ||..:..|...::|.:..:.|.     |.:..:.|       :..|.|.:..    ||..|
Worm   151 ---TIHRSKQVIFFIISVATIMYTP-----DLMAFHNK-------SHDVFDSKRN----RTMKLC 196

  Fly   213 --NATPTSAPLNETVWLNASTLLTSTTTAAPPTPSPVVRNVTVYRLYHSDLALHNASLQNATFLI 275
              :..|....|.:.::                           |::               .|..
Worm   197 YRHRAPFMLKLGDDIY---------------------------YKV---------------MFTT 219

  Fly   276 YSVVIKLIPCIALTILSVRLILALLEAKRRRKKLTSKPATPGASNGTKSPANGKAADRPRKNSKT 340
            .:|.:.|||.:.|.|.:.:|:.|:..|.||...|.||.:|...|...|......:::...|.::.
Worm   220 QTVAVHLIPSVLLVIFTWKLVGAIRVADRRHANLLSKYSTTTRSTRRKFSELTNSSENENKITRL 284

  Fly   341 LEKEKQTD---------------RTTRMLLAVLLLFLITEFPQGIMGLLNAVLGDV-FYLQCYLR 389
            .   ||.|               :.||||:.|:|||||||.|..::..::.:...: |....|..
Worm   285 F---KQRDSVSVGNEPRRAHGLKQNTRMLVVVILLFLITEIPAALIFTIHVLSVSLKFSFVDYQF 346

  Fly   390 LSDLM---DILALINSSINFILYCSMSKQFRTTFTLLFRPKFLDKWLPVAQDEMAAARAERSAVA 451
            |:.|:   ::|.:::....|.:||.||:|||.....:|..|.|..          |.|.:.::..
Worm   347 LNILLIVRNVLIVVSYPFRFAIYCGMSQQFRDVVRQMFTGKMLTH----------AIRDKDNSTT 401

  Fly   452 PVLEKG------RQQPQVVMASTTTNITQVTNLXHRRSR 484
            ..|.:|      .::..||:.|  .|.|.|::: ..|::
Worm   402 MQLVQGVTDHSDDKRQSVVLCS--ANGTLVSSVPEERAK 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	104/426 (24%)
sprr-1	NP_510555.2	7tmA_FMRFamide_R-like	30..380	CDD:320109	105/422 (25%)
		TM helix 1	32..56	CDD:320109	6/23 (26%)
		TM helix 2	64..86	CDD:320109	7/21 (33%)
		TM helix 3	112..134	CDD:320109	9/21 (43%)
		TM helix 4	157..175	CDD:320109	4/22 (18%)
		TM helix 5	214..237	CDD:320109	7/37 (19%)
		TM helix 6	279..329	CDD:320109	17/52 (33%)
		TM helix 7	348..373	CDD:320109	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910