DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MsR1 and GPR142

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_861455.1	Gene:	GPR142 / 350383	HGNCID:	20088	Length:	462	Species:	Homo sapiens

Alignment Length:	424	Identity:	83/424 - (19%)
Similarity:	148/424 - (34%)	Gaps:	146/424 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LGTIANTLNIIVLTR--REMRSPTNAILTGLAVAD--LAVMLEYIPYTIHDYILTDSLPREEKLS 98
            ||...:.|..:.|.|  ...|.|:...|..|..:|  :.|::.:..:.:...:|...:|:
Human   169 LGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQ----- 228

  Fly    99 YSWACFIKFHSIFAQVLHTISIWLTVTLAVWRYIAVGYPQKNRVWCGMRTTIITITTAYVVCVLV 163
                ..::..:|.....:..|:|:.:.|.|.||.|:.:|..:|.     .:....|...:..||
Human   229 ----AVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRA-----ASSPGRTRRAIAAVL- 283

  Fly   164 VSPSLYLITAITEYVDQLDMNGKVINSIPMTQYVIDYRNELLSARTAALNATPTSAPLNETV-WL 227
               |..|:|.|..|                  :.:|...:..|.||           |:|.: |.
Human   284 ---SAALLTGIPFY------------------WWLDMWRDTDSPRT-----------LDEVLKWA 316

  Fly   228 NASTLLTSTTTAAPPTPSPVVRNVTVYRLYHSDLALHNASLQNATFLIYSVVIKLIPCIALTILS 292
            :.                     :|||                           .|||....:.:
Human   317 HC---------------------LTVY---------------------------FIPCGVFLVTN 333

  Fly   293 VRLILALLEAKRRRKKLTSKPATPGASNGTKSPANGKAADRPRKNSKTLEKEKQTDRTTRMLLAV 357
                .|::...|||                     |::..:||           ..::|.:||.:
Human   334 ----SAIIHRLRRR---------------------GRSGLQPR-----------VGKSTAILLGI 362

  Fly   358 LLLFLITEFPQGIMGLLNAVLGDVFY-LQCYLRLSDLMDILALINSSINFILYCSMSKQFRTTFT 421
            ..||.:...|:..:.|.:..:..|.. .:.:|.| |:.:::|:::::.||.|||.:||.||.|
Human   363 TTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLAL-DVANMVAMLHTAANFGLYCFVSKTFRAT-- 424

  Fly   422 LLFRPKFLDKWLPVAQDEMAAARAERSAVAPVLE 455
              .|....|.:||..    .|::.|..|..||:|
Human   425 --VRQVIHDAYLPCT----LASQPEGMAAKPVME 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	74/394 (19%)
GPR142	NP_861455.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..123
GPR142	NP_861455.1	7tm_1	176..414	CDD:278431	63/369 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I4901
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X861
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960