DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MsR1 and dmsr-9

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_504723.1	Gene:	dmsr-9 / 260186	WormBaseID:	WBGene00022606	Length:	364	Species:	Caenorhabditis elegans

Alignment Length:	445	Identity:	93/445 - (20%)
Similarity:	179/445 - (40%)	Gaps:	138/445 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SGNNETEPLYCGSGMDNFHTSYKNMHGYVSLVVCILGTIANTLNIIVLTRREMRSP-TNAILTGL 66
            :.::|.:.|:..|.:|.....|:..|.|:...:.:....||.:.:||::::||||. .|..:..:
Worm    17 ANSDEAKDLFITSLIDTIVKPYRPYHYYILTSLVLFAFFANIMIVIVISQKEMRSSGVNVTMMLI 81

  Fly    67 AVAD----LAVMLEYIPYTIHDYILTDSLPREEKLSYSWACFIKFHSIFAQVL--------HTIS 119
            ||.|    ::.:.:.:.....||             ||     .:.:.:||::        |..|
Worm    82 AVCDFGCSVSALAQLLLRNFSDY-------------YS-----SYITAYAQLIVDYFQIAFHASS 128

  Fly   120 IWLTVTLAVWRYIAVGYPQKNR-VWCGMRTTIITITTAYVVCV---LVVSPSLYLITAITEYVDQ 180
            ::|.|.::..|.|::...:..| .|...|   ..:....|:|:   .:.|.:|:|     .||.:
Worm   129 LYLAVGMSFCRAISLVLTKDTRDTWQSPR---YALRLGIVLCLPVFFIASTNLFL-----NYVKE 185

  Fly   181 LDMNGKVINSIPMTQYVIDYRNELLSARTAALNATPTSAPLNETVWLNASTLLTSTTTAAPPTPS 245
            .|.||.|                       .|..:|.|  :..:.|.....|:.|.:
Worm   186 KDENGLV-----------------------ELEVSPLS--VANSCWYMKFALVLSGS-------- 217

  Fly   246 PVVRNVTVYRLYHSDLALHNASLQNATFLIYSVVIKLIPCIALTILSVRLILALLEAKRRRKKLT 310
                                             :.|:||||.::.||: :||..:.|.::|....
Worm   218 ---------------------------------LFKIIPCILMSGLSI-VILGKINAGKQRAIAL 248

  Fly   311 SKPATPGASNGTKSPANGKAADRPRKNSKTLEKEKQTDRTTRMLLAVLLLFLITEFPQGIMGLLN 375
            |:    ..|:.|:|                     :.||::|.:..::::|::||||||...::.
Worm   249 SR----SQSDNTQS---------------------KIDRSSRFIQCIIIIFVVTEFPQGFFSVVG 288

  Fly   376 AV-LGDVFYLQCYLRLSDLMDILALINSSINFILYCSMSKQFRTTFTLLFRPKFL 429
            .: :.|  |:..:...|...::||..|::.:||:|.::|.:||..|..||.|:|:
Worm   289 GLSIND--YINYFQFFSVFTNLLAYFNTTTSFIIYSTLSSKFRKLFVQLFVPRFI 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	85/414 (21%)
dmsr-9	NP_504723.1	7tmA_FMRFamide_R-like	40..332	CDD:320109	83/411 (20%)
		TM helix 1	42..66	CDD:320109	6/23 (26%)
		TM helix 2	75..97	CDD:320109	4/21 (19%)
		TM helix 3	115..137	CDD:320109	4/21 (19%)
		TM helix 4	161..177	CDD:320109	3/15 (20%)
		TM helix 5	209..232	CDD:320109	8/63 (13%)
		TM helix 6	261..286	CDD:320109	10/24 (42%)
		TM helix 7	300..325	CDD:320109	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BWNV
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780