DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MsR1 and dmsr-10

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_504724.1	Gene:	dmsr-10 / 191157	WormBaseID:	WBGene00022604	Length:	299	Species:	Caenorhabditis elegans

Alignment Length:	378	Identity:	85/378 - (22%)
Similarity:	148/378 - (39%)	Gaps:	126/378 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SYKNMHGYVSLVVCILGTIANTLNIIVLTRREMR-SPTNAILTGLAVADLAVMLEYIPYTIHDYI 86
            ||:..|.::...|.|....||.|.:|||:|:||| |..|..:..:::.||...:..:   |..|:
Worm    37 SYRPFHYFILACVVIFAFFANILILIVLSRKEMRYSGVNVTMMLISICDLVCAIAGL---IQLYL 98

  Fly    87 LTDSLPREEKLSYSWACFIKFHS-----IFAQVLHTISIWLTVTLAVWRYIAVGYPQKNR-VWCG 145
                    ...|.::..:||.::     .|....|..|::|.:.:|..|.:|:.....:| .|
Worm    99 --------RNFSVTYTSYIKAYTQLTVDYFQISFHAASLYLALGMAFCRVVAMSSRTDSRYTW-- 153

  Fly   146 MRTTIITITTAYVVCVLVVSPSLYLITAITEYVDQLDMNGKVINSIPMTQYVIDYRNELLSARTA 210
             ::...::..|.::|:.|                                ::....|.||: ...
Worm   154 -QSPKYSLRIALLLCIPV--------------------------------FIFGSHNVLLN-HVE 184

  Fly   211 ALNATPTSAPLNETVWLNASTLLTSTTTAAPPTPSPVVRNVTVYRLYHSDLALHNASLQNATFLI 275
            ..|.|                               :|.|::...|.:|.|.|..|...|..|
Worm   185 IENGT-------------------------------IVLNISPLSLANSCLFLKLAIFLNGLF-- 216

  Fly   276 YSVVIKLIPCIALTILSVRLILALLEAKRRRKKLTSKPATPGASNGTKSPANGKAADRPRKNSKT 340
                .|::|||.:.:||. :|||.:::.::            ||| |.|   |...|
Worm   217 ----FKIVPCILMMVLSF-VILARMKSGKK------------ASN-TNS---GNHID-------- 252

  Fly   341 LEKEKQTDRTTRMLLAVLLLFLITEFPQGIMGLLNAV-LGDVFYLQC---YLR 389
                .|..|::|.:.||:::|:|||.|||::.||..: :.|  |::|   :||
Worm   253 ----AQIVRSSRFIQAVIVVFVITEAPQGVLSLLGGLSIND--YIKCCDTFLR 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	82/371 (22%)
dmsr-10	NP_504724.1	7tmA_FMRFamide_R-like	40..289	CDD:320109	78/361 (22%)
		TM helix 1	42..66	CDD:320109	9/23 (39%)
		TM helix 2	75..96	CDD:320109	4/23 (17%)
		TM helix 3	115..137	CDD:320109	4/21 (19%)
		TM helix 4	161..177	CDD:320109	3/47 (6%)
		TM helix 5	207..230	CDD:320109	8/28 (29%)
		TM helix 6	256..281	CDD:320109	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.880