Protein Alignment MsR1 and sprr-3

DIOPT Version :10

• Sequence 1: NP_001261324.1
• Gene: MsR1 / 38298
• FlyBaseID: FBgn0035331
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_500218.2
• Gene: sprr-3 / 190541
• WormBaseID: WBGene00022086
• Length: 465
• Species: Caenorhabditis elegans
• Alignment Length: 428
• Identity: 78/428 - (18%)
• Similarity: 168/428 - (39%)
• Gaps: 121/428 - (28%)

  Fly    27 MHGYVSLVVCILGTIANTLNIIVLTRREMRSPTNAILTGLAVADLAVMLEYIPYTIHDYILTDSL 91
            ::|.:..|:.:|..::|::.|:||::::.:..:...|..:|:..|.:.:..:|:||:.|.|:..|
 Worm    53 IYGIILPVLAVLVVVSNSVVILVLSQQKSKRASVEPLLWMAICSLLMAISPLPFTIYYYNLSHHL 117

  Fly    92 PREEKLSYSWACFIKFHSIFAQVL----HTISIWLTVTLAVWRYIAVGYPQKNRVWCGMRTTIIT 152
            ...:.|   :.|:::  .:..:::    :.:.:..|:.|.|.|:|.|.||.::..||..:
 Worm   118 DFNQTL---FLCYLQ--KVCMEIMPFFFNNLVLLFTILLGVQRFIVVQYPLQSIRWCTPK----- 172

  Fly   153 ITTAYVVCVLVVSPSLYLITAITEYVDQLDMNGKVINSIPMTQYVIDYRNELLSARTAALNATPT 217
            :...|...:|:      |.|.:|.:....|:.       .:..:.|.||
 Worm   173 MVRRYSKLILI------LATFLTGFHSLYDIR-------LLYHFCIKYR---------------- 208

  Fly   218 SAPLNETVWLNASTLLTSTTTAAPPTPSPVVRNVTVYRLYHSDLALHNASLQNATFLIYSVVIKL 282
                :|:.|:....:..|:.|:|                       ..|...:|.|..:.:.|.|
 Worm   209 ----DESFWVARCFIGYSSLTSA-----------------------FGADAFSALFDYFRITINL 246

  Fly   283 IPCIALTILSVRLILALLEAKRRRKKLTSKPATPGASNGTKSPANGKAADRPRKNSKTLEKEKQT 347
            :....|.::::.||..:                             :..|.|::.....:..|.:
 Worm   247 LASGLLFVVTILLIQTI-----------------------------RTHDHPKQGVHRHKNRKTS 282

  Fly   348 DRTTRMLLAVLLLFLITEFPQGIMGLLNAVLGDVFYL-----------QCYLRLSDLMDILALIN 401
            ..||.||..:::::::...|..::.||..::.   |:           ..|||:  ..:|..:..
 Worm   283 ANTTIMLTVIIIIYMLARVPTTLLFLLVKLMD---YISVPTIAFEVMNNIYLRV--FANITTISL 342

  Fly   402 SSINFILYCSMSKQFRTTFTLLFRPKFLDKWLPVAQDE 439
            ..|:|.:|..||::||.:...|...:||      |.||
 Worm   343 HPISFAIYMFMSRKFRVSMRRLLGWRFL------ASDE 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tmA_FMRFamide_R-like	28..420	CDD:410630	72/406 (18%)
		TM helix 1	28..53	CDD:410630	7/24 (29%)
		TM helix 2	59..84	CDD:410630	6/24 (25%)
		TM helix 3	105..135	CDD:410630	5/33 (15%)
		TM helix 4	147..167	CDD:410630	2/19 (11%)
		TM helix 5	269..294	CDD:410630	5/24 (21%)
		TM helix 6	345..375	CDD:410630	7/29 (24%)
		TM helix 7	388..413	CDD:410630	6/24 (25%)
sprr-3	NP_500218.2	7tm_GPCRs	89..358	CDD:475119	63/368 (17%)
		TM helix 2	89..108	CDD:410630	4/18 (22%)
		TM helix 3	129..153	CDD:410630	2/25 (8%)
		TM helix 4	176..201	CDD:410630	6/37 (16%)
		TM helix 5	235..257	CDD:410630	5/21 (24%)
		TM helix 6	286..308	CDD:410630	4/21 (19%)
		TM helix 7	329..354	CDD:410630	7/26 (27%)