DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MsR1 and dmsr-5

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_499413.1	Gene:	dmsr-5 / 190009	WormBaseID:	WBGene00012962	Length:	401	Species:	Caenorhabditis elegans

Alignment Length:	433	Identity:	109/433 - (25%)
Similarity:	190/433 - (43%)	Gaps:	92/433 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NNETEPLYCGSGMDNFHTSYKNMHGYVSLVVCILGTIANTLNIIVLTRREMR-SPTNAILTGLAV 68
            ||.|  :|....:..|:..|..:|.|:.|.||..|.:.|:|:..||||:.|| ...||:|..:::
Worm    13 NNST--IYFFDQLIAFNQVYTVLHRYLCLFVCFFGVLLNSLHFYVLTRKAMRVYIINALLCAMSI 75

  Fly    69 ADLAVMLEYIPYTIHDYILTDSLPREEKLSYSWACFIKFHSIFAQVLHTISIWLTVTLAVWRYIA 133
            .|:..|..|..|.:. :.:.|:.......||.|..|:..|...:..|||.|::|:|.:|..|:.|
Worm    76 CDIITMTSYFIYILR-FRIFDTPSTIIGYSYPWLIFLITHVTSSIALHTTSLYLSVIMAYIRWTA 139

  Fly   134 VGYPQKNRVWCGMRTTIITITTAYVVCVLVVSPSLYLITAITEYVDQLDMNGKVINSIPMTQYVI 198
                                                        :|:||  .|.||...:.|.:|
Worm   140 --------------------------------------------LDRLD--AKWINHGALKQILI 158

  Fly   199 DYRNELLSARTAALNATPT-----SAPLNETVWLNASTLLTSTTTAAPPTPSPVVRNVTVYRLYH 258
                  .:|...::.:.||     ..|:.|.:.:|.:.||.......            :|.:..
Worm   159 ------FTALIVSVISIPTVMVHKIVPVTEVLGMNETDLLEGAKFDG------------LYTVQL 205

  Fly   259 SDLALHNASLQNATFLIYSVVIKLIPCIALTILSVRLILALLEAKRRRK------------KLTS 311
            .:..::..:|......|..::.|.:||:.:...::.||..|::...:||            :|.:
Worm   206 DETKINGCALFRVNLWITGIMFKALPCLLILWFTIALIYKLVQMSEKRKILRGEKRENVEFQLLA 270

  Fly   312 KPATPGASNGTKSPANGKAADRPRKNSKTLEKEKQTDRTTRMLLAVLLLFLITEFPQGIMGLLNA 376
            ..|||     |.:..| :|:.|.||.|: ..:....||||.||:.:|::||.||.|||::.:|:|
Worm   271 TSATP-----TTTTRN-EASPRLRKVSQ-CSRNVSIDRTTLMLIIMLVVFLCTEMPQGLLSILSA 328

  Fly   377 VLGDVFYLQCYLRLSDLMDILALINSSINFILYCSMSKQFRTT 419
            :.....:...|:.:.:::|:::|||...:||:||.||..:|.|
Worm   329 IYPTHVHTMIYVNVGEVLDLMSLINCLTSFIVYCVMSTTYRAT 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	102/408 (25%)
dmsr-5	NP_499413.1	7tmA_FMRFamide_R-like	32..372	CDD:320109	103/412 (25%)
		TM helix 1	34..58	CDD:320109	10/23 (43%)
		TM helix 2	67..89	CDD:320109	7/21 (33%)
		TM helix 3	112..134	CDD:320109	7/21 (33%)
		TM helix 4	155..171	CDD:320109	3/21 (14%)
		TM helix 5	217..240	CDD:320109	4/22 (18%)
		TM helix 6	300..325	CDD:320109	14/24 (58%)
		TM helix 7	340..365	CDD:320109	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BWNV
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45310
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28978
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109662
Panther	1	1.100	-	-	O	PTHR46273
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.790