DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MsR1 and dmsr-13

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_504730.1	Gene:	dmsr-13 / 188522	WormBaseID:	WBGene00020524	Length:	362	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	107/464 - (23%)
Similarity:	178/464 - (38%)	Gaps:	155/464 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASGNNETE---PLYCGSGMDNFHTS------------YKNMHGYVSLVVCILGTIANTLNIIVL 50
            |||..|.|:   | |...|.|....|            |:..|.|:...:.:....||.:.:.||
Worm     1 MASALNCTQFTVP-YPEPGTDEVGNSTIPWLITTVVKAYRPFHYYILTFLVVFAFFANIMIVKVL 64

  Fly    51 TRREM-RSPTNAILTGLAVAD----LAVMLE---------YIPY-TIHDYILTDSLPREEKLSYS 100
            :.:|| ||..|..:..:||.|    :|.:|:         |..| |.:..|..|.|
Worm    65 SHKEMIRSGVNVTMLLIAVCDFGCSIAGLLQLFLRSYSDNYTSYPTAYGQIAVDYL--------- 120

  Fly   101 WACFIKFHSIFAQVLHTISIWLTVTLAVWRYIAVGYPQKNR-VWCGMRTTIITITTAYVVCVLVV 164
                       |...|..|::|.|.:|..|..::....:|: :|   ::....:..|..:|..|
Worm   121 -----------AVAFHASSLYLAVGMAFCRVKSLNIANRNKDLW---QSPNYAVRVACALCAPV- 170

  Fly   165 SPSLYLITAITEYVDQLDMNGKVINSIPMTQYVIDYRNELLSARTAALNATPTSAPLNETVWLNA 229
                :||.....:          ||::..|:                          .|.::|:.
Worm   171 ----FLIATFVLF----------INAVKNTE--------------------------EEGIYLDI 195

  Fly   230 STLLTSTTTAAPPTPSPVVRNVTVYRLYHSDLALHNASL-QNATFLIYSVVIKLIPCIALTILSV 293
                                         |||:|.:..| ..|:.:...:..|:.||:.:.:||:
Worm   196 -----------------------------SDLSLLSECLFMKASLMASGLCFKIAPCLLMLVLSL 231

  Fly   294 RLILALLEAKRRRKKLTSKPATPGASNGTKSPANGKAADRPRKNSKTLEKEKQTDRTTRMLLAVL 358
            .|:..:.|.|:            .|.|   :.||.|.            |:.:.||::|.:..||
Worm   232 FLLRRIDEGKQ------------SAQN---AAANQKG------------KKDKIDRSSRFIQFVL 269

  Fly   359 LLFLITEFPQGIMGLLNAVLGDVFYLQCYLRLSDLMDILALINSSINFILYCSMSKQFRTTFTLL 423
            ::|||||.|||:..:|...: .:.|:..:..||..|:|||..|::.:||:|.|:|.:||..|..|
Worm   270 VVFLITESPQGVFSILGGFM-ILDYINYFQNLSIFMNILAFFNTTTSFIIYSSLSAKFRRIFAQL 333

  Fly   424 FRP-KFLDK 431
            |.| :.|:|
Worm   334 FLPSQVLEK 342

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	93/414 (22%)
dmsr-13	NP_504730.1	7tmA_FMRFamide_R-like	40..330	CDD:320109	90/410 (22%)
		TM helix 1	42..66	CDD:320109	6/23 (26%)
		TM helix 2	75..97	CDD:320109	6/21 (29%)
		TM helix 3	115..137	CDD:320109	8/41 (20%)
		TM helix 4	161..177	CDD:320109	5/20 (25%)
		TM helix 5	208..228	CDD:320109	4/19 (21%)
		TM helix 6	259..284	CDD:320109	13/24 (54%)
		TM helix 7	298..323	CDD:320109	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BWNV
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780