Protein Alignment MsR1 and srw-22

DIOPT Version :10

• Sequence 1: NP_001261324.1
• Gene: MsR1 / 38298
• FlyBaseID: FBgn0035331
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_506780.2
• Gene: srw-22 / 188392
• WormBaseID: WBGene00005769
• Length: 350
• Species: Caenorhabditis elegans
• Alignment Length: 449
• Identity: 79/449 - (17%)
• Similarity: 156/449 - (34%)
• Gaps: 145/449 - (32%)

  Fly    17 MDNFHTSYKNMHGYVSLVVCILGTIANTLNIIVLTRREMRSPTNAILTGLAVADLAVMLEYIPYT 81
            |.||..::.|...:.:::|       |.|:::||||:..|  .||:...:.:..|:..:::|
 Worm     1 MYNFSENFNNYVQFSNILV-------NLLHLMVLTRKNPR--CNAVFVLMIIICLSDNIQFI--- 53

  Fly    82 IHDYILTDSLPREEK---------------------LSYSWACFIKFHSIFAQVLHTISIWLTVT 125
                :..:...|:|.                     |:::..||    :....|....|.|:.:.
 Worm    54 ----LSINKFSRQESWITSFIKDQRNTKCVKKQLVVLNFTEQCF----TFIVGVFRRCSAWIALV 110

  Fly   126 LAVWRYIAVGYPQKNRVWCGMRTTIITITTAYVVCVLVVSPSLYLITAITEYVDQLDMNGKVINS 190
            :|:.|.::|.:|        |..||..:                               ||...:
 Worm   111 MALIRMLSVIFP--------MSATISKM-------------------------------GKPKGA 136

  Fly   191 IPMTQYVIDYRNELLSARTAALNATPTSAPLNETVWLNASTLLTSTTTAAPPTPSPVVRNVTVYR 255
            |.|:..|:          .|.:.....:|...:..||  ..::........|:.|...:.|.|
 Worm   137 IFMSSIVL----------LACVIIDAWAAVFLQIQWL--PDIMVKNNKNCKPSKSANEKYVLV-- 187

  Fly   256 LYHSDLALHNASLQNATFLIYSVVIKLIPCIALTILSVRLILALLEAKRRRKKLTSKPATPGASN 320
                 :...|..|.|....| .::|:....:...:|::.|:|.|...|::|
 Worm   188 -----VDQSNFDLTNQLCFI-EIIIRFFQTLLYPMLTLTLLLQLHMIKKKR-------------- 232

  Fly   321 GTKSPANGKAADRPRKNSKTLEKEKQTDRTTRMLLAVLLLFLITEFPQGIMGLLNAVLGDVFYLQ 385
             ..|..|.|..:|               ..|.:::.:.:.|::.|   |::|....|:...|.::
 Worm   233 -IISSQNDKVENR---------------NLTNLIIFMTVSFMLAE---GLVGFNGVVMYCTFVVE 278

  Fly   386 CYLR--------LSDLMDILALINSSINFILYCSMSKQFRTTF-TLLFRPKF---LDKW 432
            .:.:        .|:|:..|..:||..:..:...||.|:|.|. .::...|.   |:.|
 Worm   279 VWDKKWIIYAGAASNLIVNLRALNSLSHLFVCLFMSSQYRETVKNMMLNNKLGKSLESW 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tmA_FMRFamide_R-like	28..420	CDD:410630	71/420 (17%)
		TM helix 1	28..53	CDD:410630	6/24 (25%)
		TM helix 2	59..84	CDD:410630	4/24 (17%)
		TM helix 3	105..135	CDD:410630	5/29 (17%)
		TM helix 4	147..167	CDD:410630	2/19 (11%)
		TM helix 5	269..294	CDD:410630	4/24 (17%)
		TM helix 6	345..375	CDD:410630	5/29 (17%)
		TM helix 7	388..413	CDD:410630	5/32 (16%)
srw-22	NP_506780.2	7tm_GPCRs	7..324	CDD:475119	73/428 (17%)
		TM helix 2	38..60	CDD:410630	2/28 (7%)
		TM helix 3	91..113	CDD:410630	5/25 (20%)
		TM helix 4	135..151	CDD:410630	4/25 (16%)
		TM helix 5	186..213	CDD:410630	6/34 (18%)
		TM helix 6	247..269	CDD:410630	5/24 (21%)
		TM helix 7	286..314	CDD:410630	5/27 (19%)