DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MsR1 and srw-57

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_506997.2	Gene:	srw-57 / 185365	WormBaseID:	WBGene00005804	Length:	356	Species:	Caenorhabditis elegans

Alignment Length:	451	Identity:	95/451 - (21%)
Similarity:	168/451 - (37%)	Gaps:	128/451 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASGNNETEPLYCGSGMDNFHTSYKNM----------HGYVSLVVCILGTIANTLNIIVLTRREM 55
            |.:.:||.| .|..:..::| ..:.|:          ..::..:|.::|.:.|..::|||:|:.|
Worm     1 MNASSNEME-YYDDTDYEDF-IFWNNIMQTIIPIFEHQSHLDFLVAVIGVLVNIFHLIVLSRKSM 63

  Fly    56 RSPT-NAILTGLAVADLAVMLEYIPYTIHDY---ILTDSLPREEKLSYSW-ACFIKFHSI-FAQV 114
            |..| |..|.|:|:.|...::..:...:.:|   ..|..:|.:.....|| :.|:..||| ..::
Worm    64 RLYTINLFLIGIAICDFLRLIFNVLVALSNYYHKYQTSIMPEDCTPPKSWLSFFVSVHSITIPRI 128

  Fly   115 LHTISIWLTVTLAVWRYIAVGYPQKNRVWCGMRTTIITITTAYVVCVLVVSPSLYLITAITEYVD 179
            ...:::...|.:||.|.|.:.|| .||....::.:...|....:||:..: |..:.....||
Worm   129 FQKLAVCFGVAMAVLRVIILKYP-LNRRGQNLKRSSSGICILLIVCIPHI-PFWFFDLQWTE--- 188

  Fly   180 QLDMNGKVINSIPMTQYVIDYRNELLSARTAALNATPTSAPLNETVWLNASTLLTSTTTAAPPTP 244
             :..||                                       :|                .|
Worm   189 -IQENG---------------------------------------IW----------------KP 197

  Fly   245 SPVVRNVTVYRLYHSDLALHNASLQNATFL-IYSVVIKLIPCIALTILSVRLILALLEAKRRRKK 308
            .|...|...:.| |.:.::......:.|.| |..|:..:||.:.|.|::..||...    :..||
Worm   198 PPGCENFNDHNL-HIEYSVKPGEYSSETLLRIEGVLFTVIPSLILPIVTGTLIYFF----KTLKK 257

  Fly   309 LTSKPATPGASNGTKSPANGKAADRPRKNSKTLEKEKQTDRTTRMLLAVLLLFLITEFPQGIMGL 373
            .||.                      |.|.       ...|:|.|:..|.:.|:|..||     |
Worm   258 STSS----------------------RNND-------HNARSTIMVTLVAVTFVIATFP-----L 288

  Fly   374 LNAVLGDVFYLQCYLRLSDLM-------DILALINSSINFILYCSMSKQFRTTFTLLFRPK 427
            |...|.|  :|....||:..:       :.::|||.:::|:|...:|.|::.|...:|..|
Worm   289 LLTYLVD--FLSLGYRLAFFIILFGAFCEFVSLINGTLHFLLCAFISTQYQKTVREMFGRK 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	87/410 (21%)
srw-57	NP_506997.2	7TM_GPCR_Srw	38..347	CDD:370978	87/410 (21%)
		TM helix 1	41..60	CDD:320109	6/18 (33%)
		TM helix 2	69..91	CDD:320109	5/21 (24%)
		TM helix 3	120..142	CDD:320109	4/21 (19%)
		TM helix 4	164..179	CDD:320109	3/15 (20%)
		TM helix 5	223..246	CDD:320109	8/22 (36%)
		TM helix 6	268..293	CDD:320109	10/29 (34%)
		TM helix 7	308..333	CDD:320109	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910