Protein Alignment MsR1 and srw-67

DIOPT Version :10

• Sequence 1: NP_001261324.1
• Gene: MsR1 / 38298
• FlyBaseID: FBgn0035331
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_504900.2
• Gene: srw-67 / 184639
• WormBaseID: WBGene00005814
• Length: 369
• Species: Caenorhabditis elegans
• Alignment Length: 451
• Identity: 101/451 - (22%)
• Similarity: 182/451 - (40%)
• Gaps: 126/451 - (27%)

  Fly     3 SGNNETEPLYCGSGMDNFHTSYKNMHGYVSLVVCILGTIANTLNIIVLTRREMR-SPTNAILTGL 66
            ||..:...:..|:.:..|.:|..:...||:.:    |.|.|.|::.:|:|:.:| :..|..|.|.
 Worm    14 SGPTQNVLVSIGNFIRTFASSVVHYEYYVAWI----GAIVNVLHLYILSRKSIRCNSINIFLMGT 74

  Fly    67 AVADLAVMLEYIPYTIHDYILTDSLPREEKLSYSWACFIKFHSIFAQ--------VLHTISIWLT 123
            .:.|:..:..:    ||.|.||...|.:...:|.     .:.::|.:        ||...|.||:
 Worm    75 GICDMFCLCLF----IHAYTLTLIFPDDRCWNYH-----SYINVFIEVWVSSLNDVLRRASAWLS 130

  Fly   124 VTLAVWRYIAV--GYPQKNRVWCGMRTTIITITTAYVVCVLVVSPSLYLITAITEYVDQLDMNGK 186
            |.:|:.|::.:  ....|.:.....:..:|::..|:.|.:||   |::.:..:|  :.:::
 Worm   131 VMMALTRFLIMKNSLNPKYQFLSKPKFALISMFLAFWVSLLV---SVFYLIRVT--ITEVE---- 186

  Fly   187 VINSIPMT--QYVIDYRNELLSARTAALNATPTSAPLNETVWLNASTLLTSTTTAAPPTPSPVVR 249
                 |.|  .|..||                 .|..:|..:.:
 Worm   187 -----PWTPADYCADY-----------------LATYSEKQYSS--------------------- 208

  Fly   250 NVTVYRLYHSDLALHNASLQNATFLIYSVVIKLIPCIALTILSVRLILALLEAKRRRKKLTSKPA 314
            :||.|  :.:::.   |::|  .||:...:.|.||...|..|:|.||..|..|...::|::
 Worm   209 SVTKY--FEANIV---AAVQ--IFLVMDGLSKTIPAAILPTLTVLLIRELKVASDSKRKIS---- 262

  Fly   315 TPGASNGTKSPANGKAADRPRKNSKTLEKEKQTDRTTRMLLAVLLLFLITEFPQGIMGLLNAVLG 379
                          .|..:..:|||       ||.||:|::.:.:.|:..|.|   ||:...|.|
 Worm   263 --------------VAMRKGNENSK-------TDHTTKMVILMTICFMSAEGP---MGICTVVQG 303

  Fly   380 DVFYLQCYLRLS-DLMDILALINSSINFILYC----SMSKQFRTTFTLLF-------RPKF 428
            .|.....||.:: ||:.|..|. .:||.|.:|    ::|.|:|.....:|       |.||
 Worm   304 FVVEKSGYLGITFDLVVIFGLF-VTINAISHCLICLAVSTQYRKCAKKVFCWDRCTARKKF 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tmA_FMRFamide_R-like	28..420	CDD:410630	92/409 (22%)
		TM helix 1	28..53	CDD:410630	7/24 (29%)
		TM helix 2	59..84	CDD:410630	5/24 (21%)
		TM helix 3	105..135	CDD:410630	9/39 (23%)
		TM helix 4	147..167	CDD:410630	5/19 (26%)
		TM helix 5	269..294	CDD:410630	8/24 (33%)
		TM helix 6	345..375	CDD:410630	10/29 (34%)
		TM helix 7	388..413	CDD:410630	9/29 (31%)
srw-67	NP_504900.2	7TM_GPCR_Srw	37..354	CDD:402097	93/417 (22%)
		TM helix 2	67..92	CDD:410630	7/28 (25%)
		TM helix 3	112..142	CDD:410630	8/29 (28%)
		TM helix 4	156..176	CDD:410630	6/22 (27%)
		TM helix 5	209..246	CDD:410630	12/43 (28%)
		TM helix 6	273..302	CDD:410630	11/38 (29%)
		TM helix 7	316..341	CDD:410630	8/25 (32%)