DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MsR1 and egl-6

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001257033.1	Gene:	egl-6 / 183513	WormBaseID:	WBGene00001175	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	422	Identity:	118/422 - (27%)
Similarity:	189/422 - (44%)	Gaps:	108/422 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NFHTSYKNMHGYVSLVVCILGTIANTLNIIVLTRREMRSPTNAILTGLAVADLAVMLEYIPYTIH 83
            :|...|..:|..:|:.:||.|..:|..|||||||:.||:|.|.:||||::|...:...|..|.:.
Worm    27 SFLQYYDEIHIPLSISICIFGAASNVFNIIVLTRKRMRTPINILLTGLSIAQWLLATNYFLYLLL 91

  Fly    84 DYILTDSLPREEKLSYSWA-CFIK---FHSIFAQVLHTISIWLTVTLAVWRYIAVGYP-QKNRVW 143
            :|.      |.:.:...|: .|.:   |:.....|.|||:...|:.:||:||.|:.:| |.||..
Worm    92 EYY------RYQCVQLLWSEAFTRYRFFNVNLNTVFHTIAFTTTIVVAVFRYCALKFPIQANRFI 150

  Fly   144 CGMRTTIITITTAYVVCVLVVSPSLYLITAI-------TEYVDQLDMNGKVINSIPMTQYVIDYR 201
            ...:..|......::: :.::|..|:.|:.:       ..|..|.:|.|.:        |.:.|:
Worm   151 YKCQPAIAANVIIWII-IPIISLPLFFISEVKIVARDHVAYDLQCEMEGPL--------YDLSYQ 206

  Fly   202 NELLSARTAALNATPTSAPLNETVWLNASTLLTSTTTAAPPTPSPVVRNVTVYRLYHSDLALHNA 266
            .                                          ||:
Worm   207 E------------------------------------------SPL------------------- 210

  Fly   267 SLQNATFLIYSVVIKLIPCIALTILSVRLILALLEAKRRRKKLTSKPATPGASNGTKS--PANGK 329
             |.:|.|..:.:|.||:|.:.|:||.:.||.:|...:||||   :...|.||:..|.|  .|..|
Worm   211 -LVSAVFWAFGIVFKLLPSLILSILLIALIRSLKSVERRRK---NWKRTQGANICTNSERKAKRK 271

  Fly   330 AADRPRKNSKTLEKEKQTDRTTRMLLAVLLLFLITEFPQGIMGLLNAVLGDVFYLQCYLRLSDLM 394
            ...||              ||||||:.:|||.::.|.|.||:.|..|:.|:.|..:.|..:.:||
Worm   272 LTTRP--------------RTTRMLVIILLLCVMVELPMGILNLCVAIYGEEFGNRYYDPVGNLM 322

  Fly   395 DILALINSSINFILYCSMSKQFRTTFTLLFRP 426
            ::|.|:.||::|:|||:||.::.:||..||.|
Worm   323 EMLTLLYSSVSFVLYCTMSNEYLSTFRALFFP 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	115/411 (28%)
egl-6	NP_001257033.1	7tmA_FMRFamide_R-like	35..348	CDD:320109	111/406 (27%)
		TM helix 1	35..61	CDD:320109	12/25 (48%)
		TM helix 2	67..92	CDD:320109	8/24 (33%)
		TM helix 3	111..141	CDD:320109	11/29 (38%)
		TM helix 4	154..174	CDD:320109	2/20 (10%)
		TM helix 5	212..237	CDD:320109	9/24 (38%)
		TM helix 6	273..303	CDD:320109	16/43 (37%)
		TM helix 7	316..341	CDD:320109	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28978
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46273
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020