DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MsR1 and dmsr-8

DIOPT Version :9

Sequence 1:	NP_001261324.1	Gene:	MsR1 / 38298	FlyBaseID:	FBgn0035331	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_505697.3	Gene:	dmsr-8 / 183225	WormBaseID:	WBGene00007951	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	480	Identity:	134/480 - (27%)
Similarity:	216/480 - (45%)	Gaps:	128/480 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NETEPLYCGSGMDNFHTSYKNMHGYVSLVVCILGTIANTLNIIVLTRREMRSPTNAILTGLAVAD 70
            |.|...:..:.:.|.:|:|.::|.|||:::|:.||..|.:.:|||||..|||..|::|..:|:.|
Worm     9 NFTGAEWLETAVTNINTAYAHIHPYVSVILCLAGTAMNIVTVIVLTRPSMRSAVNSLLCAIALCD 73

  Fly    71 LAVMLEYIPYTIHDYILTDSLPREEKLSYS--WACFIKFHSIFAQVLHTISIWLTVTLAVWRYIA 133
            :.||...:.:..|..:....  |.:...|:  ||.|:.:||....:.|..||||||.||..|..:
Worm    74 ILVMTSVLVFVTHFLLFAGY--RCDPTDYNIYWAYFLYYHSQATVIFHATSIWLTVLLAQIRVFS 136

  Fly   134 V-------GYPQKNRVWCGMRTTIITITTAYVVCVLVVSPSLYLITAITEYVDQLDMNGKVINSI 191
            :       |....|::.|     ||.:||..|||:|.| |::
Worm   137 IRRATSVAGESVTNQMTC-----IIAVTTFIVVCLLNV-PNM----------------------- 172

  Fly   192 PMTQYVIDYRNELLSARTAALNATPTSAPLNETVWLNASTLLTSTTTAAPPTPSPVVRNVTVYRL 256
             :|..:|:               ||.|      :||......|:..            ::.||.:
Worm   173 -LTFEIIE---------------TPAS------LWLQCKANETAED------------DMLVYLV 203

  Fly   257 YHSDLALHNASLQNATFLIYSVVIKLIPCIALTILSVRLILALLEAKRRRKKLTSKPATPGASNG 321
            ..||    :..|.|..|....|:.|::||:.||...|.|:..:.:..:|||:|
Worm   204 APSD----HCGLLNIAFWTNGVLFKVVPCLLLTFSIVALVSIIRDVGKRRKQL------------ 252

  Fly   322 TKSPANGKAADRPRKNSKTLEKEKQ-TDRTTRMLLAVLLLFLITEFPQGIMGLLNAVL-GDVFYL 384
                            ::.:.|::. .|.||.||:|||.:||..|.|||::.:.||:. .:.||.
Worm   253 ----------------AQVMNKKRMPRDHTTPMLVAVLSIFLFAELPQGVLHVFNAIFTKETFYD 301

  Fly   385 QCYLRLSDLMDILALINSSINFILYCSMSKQFRTTFTLLF-------------RPKFLD----KW 432
            :.|:.|.|:||:|:|:||::|||:||:||::||..|..:|             ...|||    :.
Worm   302 KIYIHLGDVMDVLSLLNSAVNFIIYCAMSRKFRAVFIQIFLTCLPQKIIRKYAMEAFLDVEVSRM 366

  Fly   433 LPVA---QDEMAAARAERSAVAPVL 454
            .|.|   :.|..|..:.|.:.:.||
Worm   367 RPTADMTKSEQLALTSHRVSASSVL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	118/420 (28%)
dmsr-8	NP_505697.3	7tmA_FMRFamide_R-like	30..337	CDD:320109	117/403 (29%)
		TM helix 1	31..55	CDD:320109	11/23 (48%)
		TM helix 2	63..85	CDD:320109	6/21 (29%)
		TM helix 3	109..131	CDD:320109	10/21 (48%)
		TM helix 4	155..171	CDD:320109	9/16 (56%)
		TM helix 5	213..236	CDD:320109	8/22 (36%)
		TM helix 6	264..289	CDD:320109	14/24 (58%)
		TM helix 7	305..330	CDD:320109	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BWNV
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45310
Inparanoid	1	1.050	190	1.000	Inparanoid score	I2563
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28978
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4802
orthoMCL	1	0.900	-	-		OOG6_109662
Panther	1	1.100	-	-	O	PTHR46273
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.840