Protein Alignment MsR1 and GPR139

DIOPT Version :9

• Sequence 1: NP_001261324.1
• Gene: MsR1 / 38298
• FlyBaseID: FBgn0035331
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_001002911.1
• Gene: GPR139 / 124274
• HGNCID: 19995
• Length: 353
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 100/412 - (24%)
• Similarity: 157/412 - (38%)
• Gaps: 138/412 - (33%)

  Fly    30 YVSLVVCILGTIANTLNIIVLTR---REMRSPTNAILTGLAVADLAVM--LEYIPYTIHDYILTD 89
            |.||::| ||..||.|.:|:|::   |..:|..|.:| .||.||:.|:  :.::.:.:.|:||..
Human    32 YYSLLLC-LGLPANILTVIILSQLVARRQKSSYNYLL-ALAAADILVLFFIVFVDFLLEDFILNM 94

  Fly    90 SLPR-EEKLSYSWACFIKFHSIFAQVLHTISIWLTVTLAVWRYIAVGYPQKNRVWCGMRTTIITI 153
            .:|: .:|:..    .::|.||     || |||:||.|.:.|||||.:|.|.........|...|
Human    95 QMPQVPDKIIE----VLEFSSI-----HT-SIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVI 149

  Fly   154 TTAYVVCVLVVSPSLYLITAITEYVDQLDMNGKVINSIPMTQYVIDYRNELLSARTAALNATPTS 218
            .:.|:.|.|...|..:.....||                      ||
Human   150 VSVYITCFLTSIPYYWWPNIWTE----------------------DY------------------ 174

  Fly   219 APLNETVWLNASTLLTSTTTAAPPTPSPVVRNVTVYRLYHSDLALHNASLQNATFLIYSVVIKLI 283
                           .||:                  ::|..:.:|       .|.:|     |:
Human   175 ---------------ISTS------------------VHHVLIWIH-------CFTVY-----LV 194

  Fly   284 PCIALTILSVRLILALLEAKRRRKKLTSKPATPGASNGTKSPANGKAADRPRKNSKTLEKEKQTD 348
            ||....||:     :::..|.|||   |.....|.|.|
Human   195 PCSIFFILN-----SIIVYKLRRK---SNFRLRGYSTG--------------------------- 224

  Fly   349 RTTRMLLAVLLLFLITEFPQGIMGLLNAVLGDVFYLQCYLRLSDLMDILALINSSINFILYCSMS 413
            :||.:|..:..:|.....|:.||.|.:.....:........:||:.::|||:|::|||.|||.:|
Human   225 KTTAILFTITSIFATLWAPRIIMILYHLYGAPIQNRWLVHIMSDIANMLALLNTAINFFLYCFIS 289

  Fly   414 KQFRTTFTLLFRPKFLDKWLPV 435
            |:|||......:..|..:..||
Human   290 KRFRTMAAATLKAFFKCQKQPV 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MsR1	NP_001261324.1	7tm_4	30..427	CDD:304433	97/402 (24%)
GPR139	NP_001002911.1	7tmA_GPR139	27..296	CDD:320585	97/395 (25%)
		TM helix 1	29..53	CDD:320585	11/21 (52%)
		TM helix 2	63..85	CDD:320585	7/22 (32%)
		TM helix 3	102..124	CDD:320585	12/31 (39%)
		TM helix 4	147..163	CDD:320585	4/15 (27%)
		TM helix 5	181..204	CDD:320585	9/39 (23%)
		TM helix 6	227..249	CDD:320585	6/21 (29%)
		TM helix 7	264..289	CDD:320585	12/24 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	109	1.000	Inparanoid score	I4901
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X861
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.970