DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MsR2 and gpr139

DIOPT Version :9

Sequence 1:	NP_001261323.1	Gene:	MsR2 / 38296	FlyBaseID:	FBgn0264002	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001352082.1	Gene:	gpr139 / 798482	ZFINID:	ZDB-GENE-050823-2	Length:	363	Species:	Danio rerio

Alignment Length:	452	Identity:	110/452 - (24%)
Similarity:	178/452 - (39%)	Gaps:	165/452 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVTNMS--QPHYCGTGIDDFHTNYKYFHGYFSLIVCILGTIANTLNIIVLTR---REMRSPTNAI 60
            :.||.|  .|..|..|        ::...|:|.::| ||..||.|.:|:|::   |..:|..|.:
Zfish    10 LTTNSSSWSPRGCPLG--------QFPVVYYSSLLC-LGLPANILTVIILSQLVLRRQKSSYNYL 65

  Fly    61 LTGLAVADLAVML--EYIPYTVHDYILSVRLPREEQLSYSWACFIKFHSVFPQVLHTISIWLTVT 123
            | .|||||:.|:|  .::.:.:.|:||...||.....:..   .::|.|:     || |||:||.
Zfish    66 L-ALAVADILVLLLIVFVDFLLEDFILGAPLPHSLNKAVQ---VLEFSSI-----HT-SIWITVP 120

  Fly   124 LAVWRYIAVSYPQR-NRIWCGMRTTLITIATAYVVCVLVVSPWLYLVTAIAKFLETLDANGKTIA 187
            |.:.|||||.:|.| :.:....||..:.:| .|..|:                          |:
Zfish   121 LTIDRYIAVCHPLRYHTVSYPARTRKVILA-VYAGCL--------------------------IS 158

  Fly   188 SVPLSQYILDYNRQDEVTMQVMSSTTPDVSWAIPSDSANGTAVSLLSLTTVIPLTTLSTGVTTSS 252
            |||...:                   |::...:|..|..|                      .||
Zfish   159 SVPYYWW-------------------PELWHGLPGASPGG----------------------RSS 182

  Fly   253 SLGERNVTVYKLYHSALALRDRQFRNATFLIYSVLIKLIPC---FALTILSVRLIGALLEAKRRR 314
            |.|: :|.|:                    ::...:.|:||   |:|..:.||.
Zfish   183 SAGQ-HVLVW--------------------VHCATVYLLPCSVFFSLNAIIVRK----------- 215

  Fly   315 KILACHAANDMQPIVNGKVVIPTQPKSCKLLEKEKQTDRTTRMLLAVLLLFLVTEFPQGIMGLLN 379
              |.|.                   :||..| :...|.:||.:|||:..:|.|...|:.:|.|.:
Zfish   216 --LRCR-------------------RSCFRL-RGYSTGKTTAILLAITSVFAVLWAPRTLMILYH 258

  Fly   380 V------LLGDAFFLQCYLKLSDLMDILALINSSINFILYCSMSRQFR----STFALLFRPR 431
            :      :.|.|..|..   ::|:.::|||:|:.:||.|||.:|::||    :.....||.|
Zfish   259 LYTVQPAMPGPARLLHL---VTDVANMLALLNTGVNFFLYCFISKRFRRMAGTVLKAFFRCR 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR2	NP_001261323.1	7tm_4	28..429	CDD:304433	101/419 (24%)
gpr139	NP_001352082.1	7tmA_GPR139	28..306	CDD:320585	101/413 (24%)
		TM helix 1	28..53	CDD:320585	10/25 (40%)
		TM helix 2	61..86	CDD:320585	9/25 (36%)
		TM helix 3	100..130	CDD:320585	14/38 (37%)
		TM helix 4	142..162	CDD:320585	8/46 (17%)
		TM helix 5	186..211	CDD:320585	7/45 (16%)
		TM helix 6	228..260	CDD:320585	11/31 (35%)
		TM helix 7	274..299	CDD:320585	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	107	1.000	Inparanoid score	I4898
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D343117at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8429
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X861
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.970