Protein Alignment MsR2 and FMRFaR

DIOPT Version :10

• Sequence 1: NP_001261323.1
• Gene: MsR2 / 38296
• FlyBaseID: FBgn0264002
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_647758.1
• Gene: FMRFaR / 38357
• FlyBaseID: FBgn0035385
• Length: 549
• Species: Drosophila melanogaster
• Alignment Length: 629
• Identity: 134/629 - (21%)
• Similarity: 217/629 - (34%)
• Gaps: 227/629 - (36%)

  Fly     3 TNMSQPHYCGTGIDD---------------FHTNYKYFH--GYFSLIVCILGTIANTLNIIVLTR 50
            |::..|||...|:|.               ...|...|.  |....||.:||.:.|.:::|:|:|
  Fly    76 TDLQYPHYEDLGLDPDPNWTRICEDVYNPLLENNRIEFWVCGVLINIVGVLGILGNIISMIILSR 140

  Fly    51 REMRSPTNAILTGLAVADLAVMLEYI---------PYTVH-----DYILSVRLPREEQLSYSWAC 101
            .:|||..|.:|||||..|..:::..|         |||.|     :|:.....|
  Fly   141 PQMRSSINYLLTGLARCDTVLIITSILLFGIPSIYPYTGHFFGYYNYVYPFISP----------- 194

  Fly   102 FIKFHSVFP--QVLHTISIWLTVTLAVWRYIAVSYPQRNRIWCGMRTTLITIATA---YVVCVLV 161
                 :|||  .:..|.||::|.|:.:.||:||.:|.:.|..|       |...|   ::|||.
  Fly   195 -----AVFPIGMIAQTASIYMTFTVTLERYVAVCHPLKARALC-------TYGRAKIYFIVCVC- 246

  Fly   162 VSPWLYLVTAIAKFLETLDANGKTIASVPLSQYILDYNRQDEVTMQVMSSTTPDVSWAIPSDSAN 226
                                            :.|.||...  ..:|::.|.|:..
  Fly   247 --------------------------------FSLAYNMPR--FWEVLTVTYPEPG--------- 268

  Fly   227 GTAVSLLSLTTVIPLTTLSTGVTTSSSLGERNVTVYKLYHSALALRDRQFRNATFL------IYS 285
                                          ::|.::.:..|.|.      |:.|::      .|.
  Fly   269 ------------------------------KDVILHCVRPSRLR------RSETYINIYIHWCYL 297

  Fly   286 VLIKLIPCFALTILSVRLIGALLEAKRRRKILACHAANDMQPIVNGKVVIPTQPKSCKLLEKEKQ 350
            ::..:||...|.||:..:...:..|.|.|:                           :|...||:
  Fly   298 IVNYIIPFLTLAILNCLIYRQVKRANRERQ---------------------------RLSRSEKR 335

  Fly   351 TDRTTRMLLAVLLLFLVTEFPQGIMGLLNVLLGDAFFLQCYLKLSDLMDILALINSSINFILYCS 415
            ......|||.|:::|.:..|   :..:||:  .:||:.....|::.:.::|..||||:||::|..
  Fly   336 EIGLATMLLCVVIVFFMLNF---LPLVLNI--SEAFYSTIDHKITKISNLLITINSSVNFLIYII 395

  Fly   416 MSRQFRSTFALLFRPRWLDKWLP-LSQHDGEGRVGGSGGL-----GGYGGYGRQRLLHTDAVSKS 474
            ...:|:..|.|:|..|.|.:..| |..::......|.|.|     |.:..:|.||
  Fly   396 FGEKFKRIFLLIFFKRRLSRDQPDLIHYESSISNNGDGTLNHRSSGRFSRHGTQR---------- 450

  Fly   475 MAIDLGLTTQVTNVXQESSGRAAMSAAAGGAAASVALALAATDVDGCPPATDAAVSTNDISLVE- 538
                     ..|.. ..::|........||...:....:..|.|.|.|            .||:
  Fly   451 ---------STTTTYLVATGGPGGGGCGGGGGNNSLNNVRLTQVSGSP------------GLVKI 494

  Fly   539 KLHLQPSPRGTAISSGQHRRRRSGSGTKCIWPTT--------DW 574
            |.:..||| |..:.......:||.|.|.   .||        ||
  Fly   495 KRNRAPSP-GPVVYFPAREMQRSASTTN---STTNNNTSIGYDW 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MsR2	NP_001261323.1	7tmA_FMRFamide_R-like	24..424	CDD:410630	90/426 (21%)
		TM helix 1	25..51	CDD:410630	9/27 (33%)
		TM helix 2	57..82	CDD:410630	12/38 (32%)
		TM helix 3	103..133	CDD:410630	11/31 (35%)
		TM helix 4	145..165	CDD:410630	5/22 (23%)
		TM helix 5	263..302	CDD:410630	10/44 (23%)
		TM helix 6	349..379	CDD:410630	7/29 (24%)
		TM helix 7	392..417	CDD:410630	9/24 (38%)
FMRFaR	NP_647758.1	7tmA_FMRFamide_R-like	114..404	CDD:410630	89/424 (21%)
		TM helix 1	115..141	CDD:410630	8/25 (32%)
		TM helix 2	147..172	CDD:410630	8/24 (33%)
		TM helix 3	193..223	CDD:410630	12/45 (27%)
		TM helix 4	235..255	CDD:410630	7/52 (13%)
		TM helix 5	289..314	CDD:410630	6/24 (25%)
		TM helix 6	334..362	CDD:410630	8/30 (27%)
		TM helix 7	372..397	CDD:410630	9/24 (38%)