DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MsR2 and dmsr-12

DIOPT Version :9

Sequence 1:	NP_001261323.1	Gene:	MsR2 / 38296	FlyBaseID:	FBgn0264002	Length:	647	Species:	Drosophila melanogaster
Sequence 2:	NP_001309508.1	Gene:	dmsr-12 / 186799	WormBaseID:	WBGene00019262	Length:	160	Species:	Caenorhabditis elegans

Alignment Length:	179	Identity:	38/179 - (21%)
Similarity:	71/179 - (39%)	Gaps:	39/179 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IDDFHTN--------YKYFHGYFSLIVCILGTIANTLNIIVLTRREM-RSPTNAILTGLAVAD-- 68
            :||:...        |.:|...|:.       .||.:.:.||:.:|| ||..|..:..:||.|
Worm     2 VDDYRCKSIPAVSLLYIHFLSCFAF-------FANIMIVKVLSHKEMIRSGVNVTMLLIAVCDFG 59

  Fly    69 --LAVMLEYIPYTVHDYILSVRLPREEQLSYSWACFIKFHSVFPQVLHTISIWLTVTLAVWRYIA 131
              :|.:|:...::..|..:|........:.|..|.          ..|..|::|.|.:|..|..:
Worm    60 CSIAELLKLFLWSYSDKYISYPTAYGRLVIYYLAA----------AFHASSLYLAVGMAFCRVKS 114

  Fly   132 VSYPQRNR-IWCGMRTTLITIATAYVVCVLVVSPWLYLVTAIAKFLETL 179
            :::..||. :|   ::....:..|..:|..|     :|:|....|:..:
Worm   115 LNFANRNNDLW---QSPNYAVRVACALCAPV-----FLITTFILFMNVV 155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MsR2	NP_001261323.1	7tm_4	28..429	CDD:304433	34/158 (22%)
dmsr-12	NP_001309508.1	7tm_GPCRs	13..>157	CDD:391938	36/168 (21%)
		TM helix 1	13..39	CDD:341315	7/32 (22%)
		TM helix 2	46..71	CDD:341315	6/24 (25%)
		TM helix 3	86..116	CDD:341315	8/39 (21%)
		TM helix 4	129..149	CDD:341315	5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BWNV
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770