Protein Alignment MsR2 and dmsr-1

DIOPT Version :10

• Sequence 1: NP_001261323.1
• Gene: MsR2 / 38296
• FlyBaseID: FBgn0264002
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_741629.1
• Gene: dmsr-1 / 186437
• WormBaseID: WBGene00010191
• Length: 510
• Species: Caenorhabditis elegans
• Alignment Length: 588
• Identity: 153/588 - (26%)
• Similarity: 238/588 - (40%)
• Gaps: 155/588 - (26%)

  Fly    16 DDFHTNYKYF---HGYFSLIVCILGTIANTLNIIVLTRREMRSPTNAILTGLAVADLAVMLEYIP 77
            |.|.:.|.::   |.|.|:.:|:||||||..||:|||||.||:|.|.|||.:|..|..|:...:.
 Worm    21 DVFVSVYNFYHPIHAYLSIFLCVLGTIANFCNIVVLTRRTMRTPVNMILTAMASCDTVVLFSNLI 85

  Fly    78 YTVHDYILSVRLPREEQLSYSWACFIKFHSVFPQVLHTISIWLTVTLAVWRYIAVSYPQRNRIWC 142
            ||.|...::.:....:..|||||.|:..|:....|.|:.|:||:|.||:.||:.:    |:|  .
 Worm    86 YTTHYSFVAFKFCHPKHWSYSWALFLIAHAHLSLVAHSSSVWLSVMLALVRYVTL----RSR--G 144

  Fly   143 GMRTTLITIATAYVVCVLVVSPWLYLVTAIAKFLETLDANGKTIASVPLSQYILDYNRQDEVTMQ 207
            .|....:|:..:|           |.|......:..|:|..           .|:|    ::..|
 Worm   145 NMGGMQVTLRHSY-----------YAVAVTVSLVAVLNAPN-----------FLNY----KINEQ 183

  Fly   208 VMSSTTPDVS---WAIPSDSANGTAVSLLSLTTVIPLTTLSTGVTTSSSLGERNVTVYKLYHSAL 269
            .::.|..|:.   |..|:               .:|      |:   :.:.:.|        |.|
 Worm   184 PLNETCTDLDPMFWNSPA---------------YLP------GI---ADIAKAN--------SCL 216

  Fly   270 ALRDRQFRNATFLIYSVLIKLIPCFALTILSVRLIGALLEAKRRRKIL---ACHAANDMQPIVNG 331
            ..|      .::.|..::.|::||..|::....|:..|.|.:..|:.|   :.|...:.....||
 Worm   217 VFR------LSYWISGMVFKVLPCALLSLFVWLLLRILREVRENRQRLLKNSQHRPPNQTTTRNG 275

  Fly   332 KVVIPTQPKSCKLLEKEK------------QTDRTTRMLLAVLLLFLVTEFPQGIMGLLNVLLGD 384
                  |..|..:...||            :.||||.||||::.:.||||.|||||.:|:.:..:
 Worm   276 ------QRLSISVAGNEKLGRNGSLRGRGERVDRTTHMLLAIVAVMLVTELPQGIMAVLSGMCSE 334

  Fly   385 AFFLQCYLKLSDLMDILALINSSINFILYCSMSRQFRSTFALLFRPRWLDKWLPLSQHDGEGRVG 449
            .|.:..|..|.|::|:.:|..|..:||:|||||.|||:.|..:|.|
 Worm   335 EFRIYIYNNLGDILDLFSLCGSCCSFIIYCSMSGQFRNEFHRVFVP------------------- 380

  Fly   450 GSGGLGGYGGYGRQRLLHTDAVSKSMAIDLGLTTQVTNVXQESSGRAAMSA----AAGGAAASVA 510
                       .:.|.|...:.|.....|...||::|.: ........|:.    :....:|||.
 Worm   381 -----------AKVRCLRMSSPSIRRPSDAYSTTKMTFLKPNEKNGNGMNGNGTYSEDTRSASVK 434

  Fly   511 L--------ALAATDVDGCPPATDAAV--------------STNDISLVEKLHLQPS--PRGTAI 551
            :        :...|.:.||...|..:.              |..|.|..|..||..|  |..||.
 Worm   435 MVGIQVRRNSTEITRMTGCDSITPCSPMPTSFPSSPLPPIRSGEDESTDETSHLLNSSGPNSTAS 499

  Fly   552 SSG 554
            :.|
 Worm   500 ADG 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MsR2	NP_001261323.1	7tmA_FMRFamide_R-like	24..424	CDD:410630	121/420 (29%)
		TM helix 1	25..51	CDD:410630	15/28 (54%)
		TM helix 2	57..82	CDD:410630	9/24 (38%)
		TM helix 3	103..133	CDD:410630	11/29 (38%)
		TM helix 4	145..165	CDD:410630	2/19 (11%)
		TM helix 5	263..302	CDD:410630	8/38 (21%)
		TM helix 6	349..379	CDD:410630	18/41 (44%)
		TM helix 7	392..417	CDD:410630	10/24 (42%)
dmsr-1	NP_741629.1	7tmA_FMRFamide_R-like	32..374	CDD:410630	121/417 (29%)
		TM helix 1	33..59	CDD:410630	15/25 (60%)
		TM helix 2	65..90	CDD:410630	9/24 (38%)
		TM helix 3	111..141	CDD:410630	11/33 (33%)
		TM helix 4	154..174	CDD:410630	5/30 (17%)
		TM helix 5	218..246	CDD:410630	7/33 (21%)
		TM helix 6	299..329	CDD:410630	17/29 (59%)
		TM helix 7	342..367	CDD:410630	10/24 (42%)