Protein Alignment MsR2 and srw-29

DIOPT Version :10

• Sequence 1: NP_001261323.1
• Gene: MsR2 / 38296
• FlyBaseID: FBgn0264002
• Length: 647
• Species: Drosophila melanogaster
• Sequence 2: NP_507151.2
• Gene: srw-29 / 184965
• WormBaseID: WBGene00005776
• Length: 361
• Species: Caenorhabditis elegans
• Alignment Length: 449
• Identity: 100/449 - (22%)
• Similarity: 175/449 - (38%)
• Gaps: 130/449 - (28%)

  Fly    10 YCGTGIDDFHTNYKYFHGYFSLIVCILGTIANTLNIIVLTRREMRS-PTNAILTGLAVADL--AV 71
            :|..|  :|..::.|:..:...:|.|||.....:::.||||:.||: ..|..|.|:|:||:  ::
 Worm    20 FCAIG--NFMGDFSYYIDHVHFVVPILGAFLGLIHLTVLTRKCMRTLGINIFLIGIAIADMIRSI 82

  Fly    72 MLEYIPYTVHDYILS--VRLPREEQLSYSWACFIKFHSVFPQVLHTISIWLTVTLAVWRYIAVSY 134
            .:.:.|:....|:.:  :.|.....|||:    |...||  ::...:|||..|.:||.|.:.:.|
 Worm    83 SINFTPFFYLRYLSNEVLCLYPNSTLSYN----ISASSV--KISEALSIWFGVAIAVIRSLVMRY 141

  Fly   135 PQRNRIWCGMRTTLITIATAYVVCVLVVSPWLYLVTAIAKFLETLDANGKTIASVPLSQYILDYN 199
            |..|||   .|.|.:..:...::.:                         |:.:.|:  :.|.|.
 Worm   142 PVNNRI---NRLTQVEYSLKIIITI-------------------------TMFAFPI--WALYYT 176

  Fly   200 RQDEVTMQVMSSTTPDVSWAIPSD-----SANGTAVSLLSLTTVIPLTTLSTGVTTSSSLGERNV 259
            :       :.|:..|  .| :|..     |.|.|.:|:                         :.
 Worm   177 K-------LCSAKVP--GW-MPFTNCHRFSENSTKISI-------------------------DF 206

  Fly   260 TVYKLYHSALALRDRQFRNATFLIYSVLIKLIPCFALTILSVRLIGALLEAKRRRKILACHAAND 324
            .:.:|:.|.|      ......||..||::|||...|.|.::.|:..|.||::          |.
 Worm   207 QINRLFGSTL------IYEIDLLIEGVLLELIPSIILPITTIGLVKDLKEAQK----------NS 255

  Fly   325 MQPIVNGKVVIPTQPKSCKLLEKEKQTDRTTRMLLAVLLLFLVTEFPQGIMGLLNVLLGD-AFFL 388
            |               |.|...|...|.|:.:::..:.:.||.|..|.|:|.::.:...| ...:
 Worm   256 M---------------SIKSSTKSHDTLRSIKLVTFMTISFLFTTTPHGLMYVIGMFNTDKPGLV 305

  Fly   389 QCYLKLSDLMDILALINSSINFILYCSMSRQFRSTFALLFRPRWLDKWLPLSQHDGEGR 447
            ...||.:.|...|..:|...:.::...||.|:|:|...:|               ||||
 Worm   306 MIILKFARLFTFLTTLNGIAHILICYLMSTQYRNTANEVF---------------GEGR 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MsR2	NP_001261323.1	7tmA_FMRFamide_R-like	24..424	CDD:410630	91/410 (22%)
		TM helix 1	25..51	CDD:410630	7/25 (28%)
		TM helix 2	57..82	CDD:410630	7/26 (27%)
		TM helix 3	103..133	CDD:410630	10/29 (34%)
		TM helix 4	145..165	CDD:410630	2/19 (11%)
		TM helix 5	263..302	CDD:410630	12/38 (32%)
		TM helix 6	349..379	CDD:410630	8/29 (28%)
		TM helix 7	392..417	CDD:410630	5/24 (21%)
srw-29	NP_507151.2	7TM_GPCR_Srw	36..346	CDD:402097	92/426 (22%)
		TM helix 1	39..58	CDD:410628	6/18 (33%)
		TM helix 2	67..90	CDD:410628	7/22 (32%)
		TM helix 3	111..133	CDD:410628	7/27 (26%)
		TM helix 4	158..185	CDD:410628	6/62 (10%)
		TM helix 5	219..242	CDD:410628	9/22 (41%)
		TM helix 6	271..293	CDD:410628	6/21 (29%)
		TM helix 7	309..334	CDD:410628	5/24 (21%)