DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ecd and Ecd

DIOPT Version :9

Sequence 1:	NP_647707.1	Gene:	ecd / 38291	FlyBaseID:	FBgn0000543	Length:	684	Species:	Drosophila melanogaster
Sequence 2:	NP_081751.1	Gene:	Ecd / 70601	MGIID:	1917851	Length:	641	Species:	Mus musculus

Alignment Length:	704	Identity:	236/704 - (33%)
Similarity:	349/704 - (49%)	Gaps:	139/704 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 EDFVEYYIFPKIPDNVQDEGALRKLMLQIRNEISAIVREKSLER----------SYLWHKDEFQL 69
            ||.|||::| .|||..:.....|:::            :|.:||          .|:|....|.|
Mouse    11 EDAVEYHLF-LIPDKARGTEEHREIL------------QKYIERIMTQFAPILVPYIWQNQPFNL 62

  Fly    70 QVRLGGAEERLLNEETNPEEEAELGDLPPHFHGVTHYGDNISDEWFVVYLLTEITRARGDCIARV 134
            :.:              |.:    |.:|.|.:|:|.:||||.||||:||::.:||:...:.:|||
Mouse    63 KYK--------------PAK----GGVPAHMYGMTKFGDNIEDEWFIVYVIKQITKEFPELVARV 109

  Fly   135 SDSDGEFLLIEAADALPDWASPETCEQRVYLVGGHLQLLQNSAASSQ-----DKPLTMAMAVQRI 194
            .|:|||||||||||.||.|..|:....||:...|.|.::.....|.:     ..|.|:..|:..|
Mouse   110 EDNDGEFLLIEAADFLPKWLDPDNSANRVFFHHGELCIIPVPRKSERIPWLPMTPPTIQQALSII 174

  Fly   195 RMNPTLYRCSQEIQSCIDARLKEYQIAQPHFSIHRQVLELPHSAAQLLKQKPRLLSSAVRAFCER 259
            ..:|.....|:.||:.:|.|:..|. .:...|:||....||.....:|||:|||||:||:||..|
Mouse   175 SAHPEAVLASESIQAAVDRRVSGYP-ERVEASLHRAHCFLPAGIVAVLKQQPRLLSAAVQAFYLR 238

  Fly   260 DSLDIKALRTMRYFPPEATRVRTNVRFTRCLYAMLSHQQYLPEKRLGWHLTDPVSEPERYKEQLL 324
            |.:|::|.|..:.|.|| ||:..:|.||:||||.|..|:::|::|.|:.|..| |.|: |:...|
Mouse   239 DPIDLRACRVFKTFLPE-TRIMASVTFTKCLYAQLVQQKFVPDRRSGYGLPPP-SHPQ-YRAYEL 300

  Fly   325 GLKLASGLEILATQAKRVEGQQLEDL----PAWRSYLRSLLSKGYFRDNIEGSAEYQELLNKAKV 385
            |:|||.|.|||.::.........:.|    |.|.|:|.||....||:..::|||:|||.|..||.
Mouse   301 GMKLAHGFEILCSKCSPHFSDSRKSLVTASPLWASFLESLKRNDYFKGLMDGSAQYQERLEMAKN 365

  Fly   386 YFRGNQERFRT--ASRAGAEILDLL-LHPAEAASEELRDEENNLQPSDSDEWLNISAEDLDSMLQ 447
            ||:.:..|..:  |...|.|||.:| ..|.:.|  ||:.||.:|.|.|.|:||::|.:.||.:||
Mouse   366 YFQLSIHRPESSLAMSPGEEILTVLQTQPFDVA--ELKTEEADLPPEDDDQWLDLSPDQLDQLLQ 428

  Fly   448 DRYGPKKLYKPNGQ------MNAEEFTKQLAEFLDRQSNYEGIEHRGLEEPELDSDDDEPPPQAN 506
            |..| :|..:|..|      .:..:.:..:..|:.:.|:::|        .||..|..|.|...:
Mouse   429 DAAG-RKESQPGPQKEELQNYDVAQVSDSMKAFISKVSSHKG--------AELPRDPSEAPITFD 484

  Fly   507 GSTGLT-------AKVKKNPSMRKACQRNSVIQPEEPDSTHVRNFLDFVIPEDNWDSTSEMSDYA 564
            ..:.|.       ||                  |:|.||            ||  |...|..:..
Mouse   485 ADSFLNYFDKILGAK------------------PQESDS------------ED--DPGEEDVEGV 517

  Fly   565 DEDD------MESNLNALSGG-GSVFPLDRQIQSYMEQMDRELAQTSVGKSFHGKK---KTAPQA 619
            |.||      .||  .:|.|. ||       ::|||.:||:|||.||:|:||..::   |..|..
Mouse   518 DSDDDVGFEAQES--ESLKGALGS-------LKSYMARMDQELAHTSMGRSFTTRERLNKDPPSH 573

  Fly   620 DEDDFDDIED-------FEPININVNTLRNMMDSYQSQVGGAGPVSNLFSAMGV 666
            ..:|..|.||       .|.:::::|.:.|:::||.||.|.|||.|||..:|||
Mouse   574 TANDNSDEEDSGAGDCAVEAVDVDLNLISNILESYSSQAGLAGPASNLLHSMGV 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ecd	NP_647707.1	SGT1	18..619	CDD:284501	213/645 (33%)
Ecd	NP_081751.1	SGT1	14..597	CDD:284501	218/669 (33%)
		Transcription activation. /evidence=ECO:0000250\|UniProtKB:O95905	439..641		65/238 (27%)
		Involved in nuclear export. /evidence=ECO:0000250\|UniProtKB:O95905	481..497		1/15 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..521		10/53 (19%)
		Acidic region required for transactivation activity. /evidence=ECO:0000250\|UniProtKB:O95905	502..531		12/44 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	554..586		11/31 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850252
Domainoid	1	1.000	276	1.000	Domainoid score	I1732
eggNOG	1	0.900	-	-		E1_KOG2406
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5256
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2582
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55284
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005816
OrthoInspector	1	1.000	-	-		oto93420
orthoMCL	1	0.900	-	-		OOG6_103730
Panther	1	1.100	-	-	LDO	PTHR13060
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1332
SonicParanoid	1	1.000	-	-		X4794
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790