Protein Alignment ecd and ECD

DIOPT Version :9

• Sequence 1: NP_647707.1
• Gene: ecd / 38291
• FlyBaseID: FBgn0000543
• Length: 684
• Species: Drosophila melanogaster
• Sequence 2: NP_001129224.1
• Gene: ECD / 11319
• HGNCID: 17029
• Length: 677
• Species: Homo sapiens
• Alignment Length: 728
• Identity: 233/728 - (32%)
• Similarity: 351/728 - (48%)
• Gaps: 154/728 - (21%)

  Fly    15 EDFVEYYIFPKIPDNVQDEGALRKLMLQIRNEISAIVREKSLERSYLWHKDEFQLQVRLGGAEER 79
            ||.|||.:| .|||..:|....::::.:....|  |.|...:...|:|....|.|:.:.|
Human    11 EDTVEYCLF-LIPDESRDSDKHKEILQKYIERI--ITRFAPMLVPYIWQNQPFNLKYKPG----- 67

  Fly    80 LLNEETNPEEEAELGDLPPHFHGVTHYGDNISDEWFVVYLLTEITRARGDCIARVSDSDGEFLLI 144
                         .|.:|.|..|||.:||||.||||:||::.:||:...:.:||:.|:|||||||
Human    68 -------------KGGVPAHMFGVTKFGDNIEDEWFIVYVIKQITKEFPELVARIEDNDGEFLLI 119

  Fly   145 EAADALPDWASPETCEQRVYLVGGHLQLL---QNSAASS--QDKPLTMAMAVQRIRMNPTLYRCS 204
            ||||.||.|..||....||:...|.|.::   :.|.|.|  ...|.|:..|:..|..:......|
Human   120 EAADFLPKWLDPENSTNRVFFCHGELCIIPAPRKSGAESWLPTTPPTIPQALNIITAHSEKILAS 184

  Fly   205 QEIQSCIDARLKEYQIAQPHFSIHRQVLELPHSAAQLLKQKPRLLSSAVRAFCERDSLDIKALRT 269
            :.|::.::.|::.|. .:...|:||....||.....:|||:|||:::||:||..||.:|::|.|.
Human   185 ESIRAAVNRRIRGYP-EKIQASLHRAHCFLPAGIVAVLKQRPRLVAAAVQAFYLRDPIDLRACRV 248

  Fly   270 MRYFPPEATRVRTNVRFTRCLYAMLSHQQYLPEKRLGWHLTDPVSEPERYKEQLLGLKLASGLEI 334
            .:.|.|| ||:.|:|.||:||||.|..|:::|::|.|:.|..| |:|: |:...||:|||.|.||
Human   249 FKTFLPE-TRIMTSVTFTKCLYAQLVQQRFVPDRRSGYRLPPP-SDPQ-YRAHELGMKLAHGFEI 310

  Fly   335 LATQAKRVEGQQLEDL----PAWRSYLRSLLSKGYFRDNIEGSAEYQELLNKAKVYFRGN---QE 392
            |.::.........:.|    |.|.|:|.||....||:..|||||:|:|.|..|:.||:.:   .|
Human   311 LCSKCSPHFSDCKKSLVTASPLWASFLESLKKNDYFKGLIEGSAQYRERLEMAENYFQLSVDWPE 375

  Fly   393 RFRT--------------------------------ASRAGAEILDLL-LHPAEAASEELRDEEN 424
            |...                                |...|.|||.|| ..|.:.  |:|:.|..
Human   376 RLEVQWRDPGLLQAPPPGFTPFICLSLLSTWDNSSLAMSPGEEILTLLQTIPFDI--EDLKKEAA 438

  Fly   425 NLQPSDSDEWLNISAEDLDSMLQDRYGPKK---LYKPNGQMNAE--EFTKQLAEFLDRQSNYEGI 484
            ||.|.|.|:||::|.:.||.:||:..|.|:   :.|...:.|.:  |.::.:..|:.:.|.
Human   439 NLPPEDDDQWLDLSPDQLDQLLQEAVGKKESESVSKEEKEQNYDLTEVSESMKAFISKVST---- 499

  Fly   485 EHRGLEEPELDSDDDEPPPQANGSTGLTAKVKKNPSMRKACQRNSVIQPEEP---DSTHVRNFLD 546
             |:|.|.|                        :.||             |.|   |:....|:.|
Human   500 -HKGAELP------------------------REPS-------------EAPITFDADSFLNYFD 526

  Fly   547 FVI-PEDNWDSTSEMSDYADED----DMESNLN----------ALSGGGSVFPLDRQIQSYMEQM 596
            .:: |..|   .|:..|..|||    |.:.:|:          :|.|     .|| .::|||.||
Human   527 KILGPRPN---ESDSDDLDDEDFECLDSDDDLDFETHEPGEEASLKG-----TLD-NLKSYMAQM 582

  Fly   597 DRELAQTSVGKSFHGKKKTAP-------QADEDDFDDIED-FEPININVNTLRNMMDSYQSQVGG 653
            |:|||.|.:.|||..:.:..|       .:||:|....|. ..|:::::|.:.|:::||.||.|.
Human   583 DQELAHTCISKSFTTRNQVEPVSQTTDNNSDEEDSGTGESVMAPVDVDLNLVSNILESYSSQAGL 647

  Fly   654 AGPVSNLFSAMGV 666
            |||.|||..:|||
Human   648 AGPASNLLQSMGV 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ecd	NP_647707.1	SGT1	18..619	CDD:284501	210/675 (31%)
ECD	NP_001129224.1	SGT1	14..630	CDD:284501	215/693 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159883
Domainoid	1	1.000	279	1.000	Domainoid score	I1706
eggNOG	1	0.900	-	-		E1_KOG2406
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5256
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2568
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55284
OrthoDB	1	1.010	-	-		D359582at33208
OrthoFinder	1	1.000	-	-		FOG0005816
OrthoInspector	1	1.000	-	-		oto89846
orthoMCL	1	0.900	-	-		OOG6_103730
Panther	1	1.100	-	-	LDO	PTHR13060
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1332
SonicParanoid	1	1.000	-	-		X4794
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800