Protein Alignment oxt and Kremen1

DIOPT Version :10

• Sequence 1: NP_647705.1
• Gene: oxt / 38288
• FlyBaseID: FBgn0015360
• Length: 876
• Species: Drosophila melanogaster
• Sequence 2: NP_115772.2
• Gene: Kremen1 / 84035
• MGIID: 1933988
• Length: 473
• Species: Mus musculus
• Alignment Length: 273
• Identity: 66/273 - (24%)
• Similarity: 98/273 - (35%)
• Gaps: 90/273 - (32%)

  Fly    57 PPHAQARVQPPARTKLTAQ-----QLGFQPEC------DILAREAISALQRAKTKDCREHIAQIA 110
            ||.|:..:...|...|.|:     :.|  |||      |....::.:|||..|           .
Mouse     3 PPAARLALLSAAALTLAARPAPGPRSG--PECFTANGADYRGTQSWTALQGGK-----------P 54

  Fly   111 CAIQAGRFYAPQLRSSCPAG-----------NHTANVS--------------------------- 137
            |......|..|......|.|           |...:||
Mouse    55 CLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGN 119

  Fly   138 LGCFKDEKDRRLLAGYYSSSKTSN--SPAKCVELCLQSGYPYAGVQYGRECFCGYDPPP-KASKL 199
            |||:||..:...|.|   :|||||  :...|:..|....:.:||::.|..||||.:|.. |..:.
Mouse   120 LGCYKDHGNPPPLTG---TSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKHGEA 181

  Fly   200 PDSSCNTKCLGNAKEICGGFYAMNIYETGI----AKFTAQLAATTPSEE------TKRV------ 248
            ..:.||:.|.|:..:.|||...:.:::|.:    ..::| :||...|.:      |.||
Mouse   182 ASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSA-MAAVVYSPDFPDTYATGRVCYWTIR 245

  Fly   249 -----RIAFLLTL 256
                 ||.|..||
Mouse   246 VPGASRIHFNFTL 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
oxt	NP_647705.1	WSC	138..218	CDD:460348	28/82 (34%)
		Branch	250..504	CDD:452742	4/7 (57%)
		Xylo_C	537..709	CDD:463618
Kremen1	NP_115772.2	KR	31..114	CDD:238056	15/93 (16%)
		WSC	119..200	CDD:460348	28/83 (34%)
		CUB	214..320	CDD:238001	12/46 (26%)
		Essential for apoptotic activity. /evidence=ECO:0000269|PubMed:26206087	414..473