DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment oxt and Xylt1

DIOPT Version :9

Sequence 1:	NP_647705.1	Gene:	oxt / 38288	FlyBaseID:	FBgn0015360	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_071631.1	Gene:	Xylt1 / 64133	RGDID:	620093	Length:	955	Species:	Rattus norvegicus

Alignment Length:	857	Identity:	307/857 - (35%)
Similarity:	443/857 - (51%)	Gaps:	150/857 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GGSGSGFDAAEAPASPPPPHAQARVQPPARTKLT-AQQLGFQPECDILAREAISALQRAKTKDCR 103
            |.|..|.|.:.        |:.:|......:..| :.|:   |:|||..:||||||.|||:|.||
  Rat   220 GNSSQGKDLSR--------HSHSRKSGGGGSPETKSDQV---PKCDISGKEAISALTRAKSKHCR 273

  Fly   104 EHIAQIACAIQAGRFYAPQLRSSCPAGNHTANVSLGCFKDEKDRRLLAGYYSSSKTSNSPAKCVE 168
            :.||:..|..:.|                                ||           .|.|...
  Rat   274 QEIAETYCRHKLG--------------------------------LL-----------MPEKVAR 295

  Fly   169 LCLQSGYPYAGVQYGRECFCGYDPPPKASKLPDSSCNTKCLGNAKEICGGFYAMNIYETGIAKFT 233
            .|...|.....||:..:. ..|.||
  Rat   296 FCPLEGKANKNVQWDEDA-VEYMPP---------------------------------------- 319

  Fly   234 AQLAATTPSEETKRVRIAFLLTLNGRALRQVHRLLKALYAPEHVYYIHVDERQDYLYRKLLELES 298
                        ..|||||:|.::|||.||:.|:.||:|..:|.||||||:|.:||:|::|:...
  Rat   320 ------------NPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQFSR 372

  Fly   299 KFPNIRLARKRFSTIWGGASLLTMLLQCMEDLLQ-SNWHWDFVINLSESDFPVKTLDKLVDFLSA 362
            ::.|:|:...|.:|||||||||:..||.|.|||: ::|.|||.||||.:|:|::|.|:||.|||.
  Rat   373 QYDNVRVTSWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSR 437

  Fly   363 NPGRNFVKGHGRETQKFIQKQGLDKTFVECDTHMWRIGDRKLPAGIQVDGGSDWVALSRPFVGYV 427
            ....||:|.|||:..:||:|||||:.|:||||||||:|||::|.||.|||||||..|:|.||.||
  Rat   438 YRDMNFLKSHGRDNARFIRKQGLDRLFLECDTHMWRLGDRRIPEGIAVDGGSDWFLLNRKFVEYV 502

  Fly   428 THPREDDELLQALLKLFRHTLLPAESFFHTVLRNTKHCTSYVDNNLHVTNWKRKQGCKCQYKHVV 492
            ..  ..|:|:..:.:.:.:|||||||||||||.|:.||.:.|||||.:|||.||.||||||||:|
  Rat   503 AF--STDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIV 565

  Fly   493 DWCGCSPNDFKPEDWPRLQATEQKSLFFARKFEPVINQAVLLQLEEWLYGPYTSEYANLHGYWQS 557
            ||||||||||||:|:.|.|.|.:.: |||||||.::||.::.||:.:|||.|.:....|..||::
  Rat   566 DWCGCSPNDFKPQDFHRFQQTARPT-FFARKFEAIVNQEIIGQLDSYLYGNYPAGTPGLRSYWEN 629

  Fly   558 LYHHEDVHGSGDDLARSIGDSVMRLSARQA------------KLYPLELIELTH-YLHRDQYKGF 609
            :|...|...|..|:|.::..|.:||..|:|            :.||:......| |...|:::||
  Rat   630 VYDEPDGIQSLSDVALTMYHSFIRLGLRRAESSLHTDGENSCRYYPMGHPASVHLYFLADRFQGF 694

  Fly   610 LVRYRARG-STGKPLHLETRVRPTQQGKLARNARFSKRLRNFEVSTDFDQKEQIARNFGKLLGPQ 673
            |:::.... :..|...|||.:.|.:..|:|.......||:..||.||:|.||::.||||.||||.
  Rat   695 LIKHHVTNLAVSKLETLETWMMPKKVFKVASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPM 759

  Fly   674 SDLLLSYTLQANADSGAASHSYNLTLLWIDPLGRLQDFNELHVEDSTSDVINHSKTLLKHPITPG 738
            .:       ...........:..:|::|:||:..:....::.:| ||:: ..|.|..|..|:.||
  Rat   760 DE-------PVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIE-STAE-FTHYKPPLNLPLRPG 815

  Fly   739 IWTAKLIGRNSIYAQLKFLIAPLAYYKGYPLAKSSDAEALNAGLTVALPEDFEMPVEWQQHLQTD 803
            :||.|::......|:.|||:|||.:....|: |..:|..|:.|    .|....|    :|..|:.
  Rat   816 VWTVKILHHWVPVAETKFLVAPLTFSNKQPI-KPEEALKLHNG----PPRSAYM----EQSFQSL 871

  Fly   804 DEQFTMR------EESLAKGKMLGQELHSWIDGLVGQFFQLRESCVVEADSEVSLPLCSDAPWSS 862
            :...::.      |::.......|..|.:|:|.|||..:...:.|.....:...:..||...|||
  Rat   872 NPVLSLHINPAQVEQARKNAAFTGTALEAWLDSLVGGTWTAMDVCATGPTACPVMQTCSQTAWSS 936

  Fly   863 LAPDPKSDVDAL 874
            .:|||||::.|:
  Rat   937 FSPDPKSELGAV 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
oxt	NP_647705.1	WSC	138..218	CDD:280068	11/79 (14%)
		Branch	250..503	CDD:280621	147/253 (58%)
		Xylo_C	537..710	CDD:289306	53/186 (28%)
Xylt1	NP_071631.1	Branch	324..576	CDD:391737	147/253 (58%)
Xylt1	NP_071631.1	Xylo_C	609..789	CDD:372167	53/186 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350565
Domainoid	1	1.000	334	1.000	Domainoid score	I1092
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32534
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1151
OMA	1	1.010	-	-		QHG49999
OrthoDB	1	1.010	-	-		D258128at33208
OrthoFinder	1	1.000	-	-		FOG0003123
OrthoInspector	1	1.000	-	-		otm45788
orthoMCL	1	0.900	-	-		OOG6_102671
Panther	1	1.100	-	-	O	PTHR46025
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X616
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910