DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment oxt and xylt1

DIOPT Version :9

Sequence 1:	NP_647705.1	Gene:	oxt / 38288	FlyBaseID:	FBgn0015360	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_001165868.1	Gene:	xylt1 / 560951	ZFINID:	ZDB-GENE-111017-2	Length:	919	Species:	Danio rerio

Alignment Length:	856	Identity:	312/856 - (36%)
Similarity:	430/856 - (50%)	Gaps:	163/856 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PASPPPPHAQAR--VQPPARTKLTAQQLGFQ--PECDILAREAISALQRAKTKDCREHIAQIACA 112
            |...|....|.|  .|.|.|:......:.:.  |:|:|..:||||||.|||||:||:.|.::.|.
Zfish   181 PTLRPQQSQQHRHHFQRPKRSITPTADIKYDQPPKCEISGKEAISALSRAKTKECRQQIVEVYCR 245

  Fly   113 IQAGRFYAPQLRSSCPAGNHTANVSLGCFKDEKDRRLLAGYYSSSKTSNSPAKCVELCLQSGYPY 177
                                           .|:.:|:            |.|....|...|...
Zfish   246 -------------------------------HKEHQLM------------PEKVTRYCPVEGKVN 267

  Fly   178 AGVQYGRECFCGYDPPPKASKLPDSSCNTKCLGNAKEICGGFYAMNIYETGIAKFTAQLAATTPS 242
            ..||:..:..                                                  .|.|:
Zfish   268 MNVQWEEDSM--------------------------------------------------ETVPA 282

  Fly   243 EETKRVRIAFLLTLNGRALRQVHRLLKALYAPEHVYYIHVDERQDYLYRKLLELESKFPNIRLAR 307
            ..   |||||:|.::|||.|||.||.||:|...|.||||||:|.:||:|:::.|..::||:|:..
Zfish   283 VP---VRIAFMLVVHGRATRQVQRLFKAIYHTSHFYYIHVDQRSNYLHRQMVALAHQYPNVRVTS 344

  Fly   308 KRFSTIWGGASLLTMLLQCMEDLL-QSNWHWDFVINLSESDFPVKTLDKLVDFLSANPGRNFVKG 371
            .|.||||||||||||.||.|:||| ..:|.|||.||||.:|:|::|.|:||.|||.....||:|.
Zfish   345 WRMSTIWGGASLLTMYLQSMKDLLAMRDWSWDFFINLSAADYPIRTNDQLVAFLSKYRNMNFIKS 409

  Fly   372 HGRETQKFIQKQGLDKTFVECDTHMWRIGDRKLPAGIQVDGGSDWVALSRPFVGYVTHPREDDEL 436
            |||:..:||:|||||:.|.||||||||:||||:|.||.|||||||..|:|.||.||.:.:  |:|
Zfish   410 HGRDNARFIRKQGLDRLFFECDTHMWRLGDRKIPEGISVDGGSDWFLLNRMFVEYVINTQ--DDL 472

  Fly   437 LQALLKLFRHTLLPAESFFHTVLRNTKHCTSYVDNNLHVTNWKRKQGCKCQYKHVVDWCGCSPND 501
            :..:.:.:.:|||||||||||||.|:.||.|.|||||.:|||.||.||||||||:||||||||||
Zfish   473 VTNMKRFYAYTLLPAESFFHTVLENSPHCESMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPND 537

  Fly   502 FKPEDWPRLQATEQKSLFFARKFEPVINQAVLLQLEEWLYGPYTSEYANLHGYWQSLYHHED-VH 565
            |||.|.||.|.|.:.: |||||||..:||.::.||:.:|:|........|..||::::...| :|
Zfish   538 FKPSDLPRFQQTTRPT-FFARKFEASVNQEIVNQLDVFLFGSLPQGTPGLKAYWENVFDEADGIH 601

  Fly   566 GSGD------------DLARSI----GDSVMRLSARQAKLYPLELIELTH-YLHRDQYKGFLVRY 613
            ...|            .|||:.    ||.........|..:|:.:    | |...|:::|:|||:
Zfish   602 SLSDAHLTHYHAFARLGLARTANSLQGDPNDNSCRYFAMGHPVSV----HIYFLSDEFQGYLVRH 662

  Fly   614 RARG-STGKPLHLETRVRPTQQGKLARNARFSKRLRNFEVSTDFDQKEQIARNFGKLLGPQSDLL 677
            .|.. :|.|...|||.|.|.|..|.....:...||:..|:.||:|.||:|.||||.::||..:
Zfish   663 HATNLATSKLETLETWVMPKQFYKFTNPPKTFTRLQFAEIGTDWDAKERIFRNFGNMMGPMDE-- 725

  Fly   678 LSYTLQANADSGAASHSYNLTLLWIDPLGRLQDFNELHVEDSTSDVINHSKTLLKHPITPGIWTA 742
                 ...........:..:|::||||...:....::.::.|..  ..|.:..|..|:.||:||.
Zfish   726 -----PVGMQKWGKGSNVTVTVVWIDPTNVIAATYDILIDASAE--FTHYRPPLNLPLRPGMWTV 783

  Fly   743 KLIGRNSIYAQLKFLIAPLAYYKGYPL------------AKSSDAEALNAGLTVALPEDFEMPVE 795
            :::...|..|:.:|||.||.::|..|:            ||:|..|....||...|    .:||
Zfish   784 RVLHHWSPVAETRFLITPLTHHKHLPIRHEDALKMHNGPAKNSYMEQSFHGLNPIL----NIPV- 843

  Fly   796 WQQHLQTDDEQFTMREESLAKGKMLGQELHSWIDGLVGQFFQLRESCVVEADSEVSLPLCSDAPW 860
               ||    .|....|.:..   :.|.||..|:|.|||..:...:.|.........:..|.:..|
Zfish   844 ---HL----GQVEAAEHNAG---LTGSELERWVDSLVGDVWSAVDVCSTGPSGCPVMQTCRETVW 898

  Fly   861 SSLAPDPKSDV 871
            |||:|||||.:
Zfish   899 SSLSPDPKSQL 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
oxt	NP_647705.1	WSC	138..218	CDD:280068	8/79 (10%)
		Branch	250..503	CDD:280621	155/253 (61%)
		Xylo_C	537..710	CDD:289306	52/191 (27%)
xylt1	NP_001165868.1	Branch	287..539	CDD:280621	155/253 (61%)
xylt1	NP_001165868.1	Xylo_C	572..753	CDD:289306	52/191 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592270
Domainoid	1	1.000	345	1.000	Domainoid score	I1024
eggNOG	1	0.900	-	-		E1_KOG0799
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32534
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1137
OMA	1	1.010	-	-		QHG49999
OrthoDB	1	1.010	-	-		D258128at33208
OrthoFinder	1	1.000	-	-		FOG0003123
OrthoInspector	1	1.000	-	-		otm25404
orthoMCL	1	0.900	-	-		OOG6_102671
Panther	1	1.100	-	-	O	PTHR46025
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2902
SonicParanoid	1	1.000	-	-		X616
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800