DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment oxt and xylt2

DIOPT Version :9

Sequence 1:	NP_647705.1	Gene:	oxt / 38288	FlyBaseID:	FBgn0015360	Length:	876	Species:	Drosophila melanogaster
Sequence 2:	NP_001006733.1	Gene:	xylt2 / 448400	XenbaseID:	XB-GENE-993408	Length:	834	Species:	Xenopus tropicalis

Alignment Length:	954	Identity:	322/954 - (33%)
Similarity:	467/954 - (48%)	Gaps:	221/954 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SARWLK---RYRAF---FLILLLI--VAIQLFLAYK------SLDIVGGGSGSGFDAAEAPASPP 56
            |.|.||   ||:..   .|:||||  :|:..|...:      ||..|.....:|..|.::.:|..
Frog     4 SVRGLKLGRRYKLLAGAALVLLLIQGLAVWSFSGLEGDGKENSLPRVNRSPDNGEVAKDSDSSAG 68

  Fly    57 PPHAQARVQPPAR----TKLTAQ-------------------------------------QLGFQ 80
            ....:..|:|..|    :|:|.:                                     ..||.
Frog    69 SRSQRWTVRPERRSSDGSKITRKATVTRKQRPPAQVFHGNWHNLTREGDTGSVEGAPHQSDRGFT 133

  Fly    81 PECDILAREAISALQRAKTKDCREHIAQIACAIQAGRFYAPQLRSSCPAGNHTANVSLGCFKDEK 145
            |:|:|..::|:|||.||:|..|::.||.:.|..|||......::..|..   |..|:.|...:|.
Frog   134 PKCEITGKDALSALARARTHQCQQEIANLVCLHQAGELMPRNVQRQCQT---TGKVNTGLTWEES 195

  Fly   146 DRRLLAGYYSSSKTSNSPAKCVELCLQSGYPYAGVQYGRECFCGYDPPPKASKLPDSSCNTKCLG 210
            |                                          ...|||:
Frog   196 D------------------------------------------AVAPPPE--------------- 203

  Fly   211 NAKEICGGFYAMNIYETGIAKFTAQLAATTPSEETKRVRIAFLLTLNGRALRQVHRLLKALYAPE 275
                                               |.:|:.::|.::|||:||:.||:||:|..:
Frog   204 -----------------------------------KPLRVLYMLVVHGRAIRQLKRLIKAIYHQD 233

  Fly   276 HVYYIHVDERQDYLYRKLLELESKFPNIRLARKRFSTIWGGASLLTMLLQCMEDLLQ-SNWHWDF 339
            |.||||||:|.:||:|:::.|...:.|:|:...|..|||||||||||.|:.|:|||: .:|.|||
Frog   234 HFYYIHVDQRSNYLHREVVRLAQSYENMRVTPWRMVTIWGGASLLTMYLRSMKDLLEVPDWPWDF 298

  Fly   340 VINLSESDFPVKTLDKLVDFLSANPGRNFVKGHGRETQKFIQKQGLDKTFVECDTHMWRIGDRKL 404
            .||||.:|:|.:|.::||.|||.:..:||:|.|||:..:||:|||||:.|.|||:||||:|:|::
Frog   299 FINLSATDYPTRTNEELVLFLSKHRHKNFLKSHGRDNARFIKKQGLDRLFHECDSHMWRLGERQI 363

  Fly   405 PAGIQVDGGSDWVALSRPFVGYVTHPREDDELLQALLKLFRHTLLPAESFFHTVLRNTKHCTSYV 469
            |.||.|||||||.||:|.||.|||:.:  |.|:..|.:.:::|||||||||||||.|:|.|.|.|
Frog   364 PEGIVVDGGSDWFALTRNFVEYVTYTK--DILVSELRRFYKYTLLPAESFFHTVLENSKACDSLV 426

  Fly   470 DNNLHVTNWKRKQGCKCQYKHVVDWCGCSPNDFKPEDWPRLQATEQKSLFFARKFEPVINQAVLL 534
            ||||.||||.||.||:|||||:|||||||||||||:|..|||...:.: |||||||..:||.||.
Frog   427 DNNLRVTNWNRKLGCRCQYKHIVDWCGCSPNDFKPQDVVRLQQLSRPT-FFARKFESSVNQEVLD 490

  Fly   535 QLEEWLYGPYTSEYANLHGYWQSLYHHEDVHGSGDDLARSIGDSVMRLSARQAKLYPLEL----- 594
            .|:..|:|...||...:.|||:|:|...|..|...|:..::..:..||:..:.:....|.
Frog   491 ILDAHLFGELPSETPGIKGYWESVYDSIDGLGGLSDVTMTVYAAFTRLALHELQGSKKETRQPSC 555

  Fly   595 ----------IELTHYLHRDQYKGFLVRYRAR-GSTGKPLHLETRVRPTQQGKLARNARFSKRLR 648
                      :||  |.:.|.::|:||:...: |.|     ||..:.|....||:.......|::
Frog   556 WFTASGLPSSVEL--YFYDDHFQGYLVKQEVQSGET-----LEIWMMPQGSLKLSEQGEAIGRIQ 613

  Fly   649 NFEVSTDFDQKEQIARNFGKLLGPQSDLLLSYTLQANADSGAA----SHSYNL--TLLWIDPLGR 707
            ..||.|::|.||:|.||||.|:||             .|...|    |...||  |::||||
Frog   614 GLEVGTEWDPKERIFRNFGGLIGP-------------FDEPVAVQKWSRGLNLTVTVVWIDP--- 662

  Fly   708 LQDFNELHVEDSTSDVI-------NHSKTLLKHPITPGIWTAKLIGRNSIYAQLKFLIAPLAYYK 765
                  .::..::.|:|       ...|..|..|:.||.||.:|:....:.|:::||:.||....
Frog   663 ------TYIIAASYDIIVDIDADFTQYKPPLARPLRPGYWTVRLLRFWELLAEVRFLVVPLTVRN 721

  Fly   766 GYPLAKSSDAEALNAGLTVALPEDFEMPVEWQQ--HLQTDDEQFTMREESLAKGKMLGQELHSWI 828
            ..||.|..  ..|:||    .|:...|...:|.  .:.....:.....|:..|.::||:||.:|.
Frog   722 KEPLRKGD--RWLHAG----PPKGQYMEQNFQALGGILNLPPRVEAEREAKGKSELLGKELEAWT 780

  Fly   829 DGLVGQFFQLRESCVVEADSEV-SLPLCSDAPWSSLAPDPKSDV 871
            |..:..|:.:...|..:|.... |||:||...|||::|||||::
Frog   781 DESLRSFWSVGGVCTKDASKSCPSLPVCSATRWSSMSPDPKSEL 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
oxt	NP_647705.1	WSC	138..218	CDD:280068	6/79 (8%)
		Branch	250..503	CDD:280621	147/253 (58%)
		Xylo_C	537..710	CDD:289306	54/194 (28%)
xylt2	NP_001006733.1	Branch	210..460	CDD:332239	147/251 (59%)
xylt2	NP_001006733.1	Xylo_C	493..668	CDD:315242	54/203 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	339	1.000	Domainoid score	I1103
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	545	1.000	Inparanoid score	I1133
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D258128at33208
OrthoFinder	1	1.000	-	-		FOG0003123
OrthoInspector	1	1.000	-	-		otm48881
Panther	1	1.100	-	-	LDO	PTHR46025
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X616
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160